MIR20A (MicroRNA 20a)

LC-derived exosomal circ_001895 stimulated M2 macrophage polarization to promote LC metastasis via the miR-20a-5p/JAK1/STAT3 axis. These findings suggest that exosomal circ_001895 may serve as a potential biomarker and therapeutic target in lung cancer.

Therefore, these findings suggest that miRNAs may serve as predictive biomarkers and potential therapeutic targets in the management of breast cancer.

Our findings suggest that miR-20a-5p plays an oncogenic role in luminal breast cancer by promoting EMT, while MALAT1 may contribute to disease progression through indirect regulatory mechanisms. Finally, MALAT1 and miR-20a-5p might serve as potential therapeutic and prognostic targets in LBC.

Enrichment analysis showed strong overrepresentation of metabolic process-related GO terms and cancer-associated KEGG pathways. These findings refine the list of promising ncRNA biomarkers and highlight candidates for future clinical validation.

Distinct mirna signatures differentiate radiation-resistant and radiation-sensitive prostate cancer cells. Mir-20a-5p, mir-128-3p, and mir-135b-5p may contribute to radioresistance, whereas mir-23b-3p and mir-381-3p may act as radiosensitizers.

Although promising, clinical implementation of miRNA-based assays requires further validation, standardization of protocols, and large-scale prospective studies. Harnessing circulating miRNAs could usher in a new era of precision oncology for PCa, improving early diagnosis, prognostication, and real-time therapeutic guidance.

Overall, the study highlights a probable mechanism for miRNA packaging and release in OC through EpCAM-positive exosomes, offering potential biomarkers for monitoring disease progression and relapse.

A weak negative correlation between PTEN and three miRNAs, and weak positive correlations between CCND1 and miR-106b-5p and also TP53 and miR-20a-5p were observed. These findings emphasize the potential role of HPV and related biomarkers in the progression of breast cancer, indicating avenues for further research and therapeutic strategies.

In summary, we first screened ferroptosis-related key hub genes linking hypoxia and osteoporosis. The findings suggest that JUN, SQSTM1​, STAT3​ ​, CD44​​ and TGFBR1 are significantly associated with OP and hypoxia, potentially serving as biomarkers for diseases linked to ferroptosis. Additionally, hsa-miR-20a-5p was identified as a crucial upstream regulator likely involved in the regulation of these genes simultaneously.

Thus, in this comprehensive narrative review, we map the range of candidate ncRNAs reported in the literature and discuss their predictive, diagnostic, prognostic and therapeutic value, including their potential as circulating biomarkers in CC. We also highlight, as a future perspective, how integrated profiling approaches could guide research and support the development of non-invasive strategies for diagnosis, prognostic assessment, and therapy monitoring in CC.