MIR208A (MicroRNA 208a)

Furthermore, our multivariable Cox analysis suggested that elevated serum miR-208a levels were associated with an increased risk for cancer recurrence and/or cancer metastasis (HR=7.5, 95% CI: 2.5-24.9, P<0.01) and cancer death risk (HR=5.3, 95% CI: 1.7-18.5, P<0.05) after age, gender, smoking, drinking and tumor node metastasis (TNM) stage were controlled for. This study further provided evidence that elevated serum miR-208a levels after radiotherapy were associated with a high risk for cancer recurrence and/or metastasis and death among NSCLC patients.

Thus, significant metabolomic imbalance in the urine was observed in the OC patients and was associated with changes in the levels of microRNAs that regulate the signaling pathways of the metabolites. The 26 compounds with abnormal concentrations and the levels of the microRNAs miR-33b-5p, miR-423-5p, miR-6843-3p, miR-4668-3p, miR-30c-5p, miR-6743-5p, miR-4742-5p, miR-1207-5p, and miR-17-5p in the urine were considered to be suitable as noninvasive diagnostic markers of OC.

Redox Signal. 00, 000-000.

MiR-450b-5p and miR-210-3p can increase the tolerance of cardiomyocytes to hypoxia/reoxygenation through the inhibition of ferroptosis. Circ_0091761 RNA, miR-214-3p, miR-199a-5p, miR-208a/b, miR-375-3p, miR-26b-5p and miR-15a-5p can aggravate myocardial ferroptosis.

Examining PDCD4 and miR-21 transcript levels may help detect the transition from OED to OSCC. This work suggests that PDCD4 and miR-21 expression levels in liquid biopsies may be biomarkers for OED monitoring in the future.

Sequence analysis of virus progeny from treated mice revealed a high prevalence of miRT sequences loss among MC- and MC- viral genomes, but not in MC-NC. Overall, MC-NC was capable of stably retaining miRT sites and provided a more effective treatment and is therefore our lead Mengovirus candidate for clinical translation.

MiRNAs that impact proliferation, cell survival, and signaling pathways that promote regeneration were induced during cardiovascular repair in the sheep model. This information can be used to design new approaches for the optimization of miRNA-based treatments for the heart.

Serum miRNAs could serve as potential diagnostic tools for the diagnosis of HCC.

The data suggest that miR-133a is associated with DOX-based cardiotoxicity during chemotherapy in breast cancer patients through ErbB2 signaling pathway. Moreover, miR-133a may be a future marker of DOX-induced cardiotoxicity in women with breast cancer.