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GENE:

MIR204 (MicroRNA 204)

News alerts, weekly reports and conference planners

STARD4-AS1 promotes coronary artery disease and modulates endothelial dysfunction by targeting miR-204-3p/FLI1. (PubMed, Microvasc Res)

STARD4-AS1 can regulate endothelial cell functions under hypoxic conditions. This study highlights its potential as a novel therapeutic target and a promising circulating biomarker candidate for CAD.

5 days ago

Journal

FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • MIR204 (MicroRNA 204)

11d

Gastric Cancer Epithelial-Mesenchymal Transition-The Role of Micro-RNA. (PubMed, Cancers (Basel))

Several EMT-related miRNAs show consistent associations with invasion, metastasis, peritoneal dissemination, prognosis, and chemoresistance, and many are detectable in circulation. Overall, EMT-related miRNAs orchestrate gastric cancer cell plasticity and tumor-microenvironment crosstalk and represent promising biomarker and therapeutic candidates that warrant validation in prospective, subtype-stratified, and translational studies.

11 days ago

Review • Journal

MET (MET proto-oncogene, receptor tyrosine kinase) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR21 (MicroRNA 21) • MIR34A (MicroRNA 34a-5p) • TGFB1 (Transforming Growth Factor Beta 1) • MIR192 (MicroRNA 192) • MIR27A (MicroRNA 27a) • MIR17 (MicroRNA 17) • MIR23A (MicroRNA 23a) • MIR375 (MicroRNA 375) • MIR506 (MicroRNA 506) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • MIR106B (MicroRNA 106b) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR150 (MicroRNA 150) • MIR181A1 (MicroRNA 181a-1) • MIR200 (MicroRNA 200) • MIR204 (MicroRNA 204) • MIR218 (MicroRNA 218) • MIR26A1 (MicroRNA 26a-1) • MIR30A (MicroRNA 30a)

Analysis of the expression of ARNTL2 and miR-204-5p and their correlation with clinical pathological features in NSCLC patients. (PubMed, Am J Clin Exp Immunol)

The expression levels of ARNTL2 and miR-204-5p in NSCLC are closely associated with patient age, tumor differentiation, and lymph node metastasis, and they have high predictive value for NSCLC-related mortality.

1 month ago

Journal

AHR (Aryl hydrocarbon receptor) • ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator) • ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator Like) • MIR204 (MicroRNA 204)

Extracellular vesicle-associated lncRNA LYPLAL1-DT mediates endothelial-cancer cell communication, promoting small cell lung cancer progression. (PubMed, Extracell Vesicles Circ Nucl Acids)

In the current study, we investigated the bidirectional communication mediated by exRNA LYPLAL1-DT between SCLC and endothelial cells, while also exploring its potential regulatory targets. This research provides a potential circulating biomarker for the diagnosis, prognosis, and treatment of SCLC.

1 month ago

Journal

BCL2 (B-cell CLL/lymphoma 2) • MIR204 (MicroRNA 204)

2ms

Retraction Notice to: Oncogenic Role of Long Noncoding RNAMALAT1 in Thyroid Cancer Progression through Regulation of the miR-204/IGF2BP2/m6A-MYC Signaling. (PubMed, Mol Ther Nucleic Acids)

[This retracts the article DOI: 10.1016/j.omtn.2020.09.023.].

2 months ago

Journal

MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2) • MIR204 (MicroRNA 204)

2ms

The ceRNA network of LINC00536/miR-204-5p/TGFBR2: A novel therapeutic target for breast cancer diagnosis and treatment. (PubMed, Cell Signal)

LINC00536 promotes BC progression and activates TGF-β signaling via miR-204-5p/TGFBR2, with its expression correlating with features of the TME, establishing its potential as a diagnostic/prognostic biomarker and therapeutic target.

2 months ago

Journal

TGFBR2 (Transforming Growth Factor Beta Receptor 2) • TGFB1 (Transforming Growth Factor Beta 1) • LINC00536 (Long Intergenic Non-Protein Coding RNA 536) • MIR204 (MicroRNA 204)

2ms

CircRNA CeRNA networks in gastric cancer highlight FAP/FNDC1 as potential prognostic and therapeutic targets. (PubMed, Discov Oncol)

This study identifies three key pathways, two novel prognostic ceRNA networks, six prognosis-related circRNAs, and two target genes (FAP/FNDC1) for GC, offering new directions for GC therapy.

2 months ago

Journal

IL17A (Interleukin 17A) • FNDC1 (Fibronectin Type III Domain Containing 1) • MIR204 (MicroRNA 204)

3ms

miR-204-5p for silica induced macrophage inflammatory effect (PubMed, Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi)

The levels of inflammatory factors IL-6, TNF-α, and TGF-β(1) and the expression level of protein iNOS were significantly decreased (P<0.05) . miR-204-5P alleviates SiO(2)(-) induced macrophage inflammation by regulating the wnt/β-catenin pathway and JAK2/STAT3 pathway.

3 months ago

Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • TCF7L2 (Transcription Factor 7 Like 2) • TGFB1 (Transforming Growth Factor Beta 1) • MMP9 (Matrix metallopeptidase 9) • MIR204 (MicroRNA 204) • TCF4 (Transcription Factor 4)

3ms

Indoxyl sulfate promoted glutamine metabolism and cell proliferation in urothelial carcinoma involving Runx2. (PubMed, Biomed Pharmacother)

The cancer-promoting effects of indoxyl sulfate were further demonstrated in tumor-bearing mice. In short, our results suggest that indoxyl sulfate may act as a bridge in linking the gap between CKD and urothelial carcinoma by involving the enhancement of glutamine uptake and metabolism.

3 months ago

Journal

SLC1A5 (Solute Carrier Family 1 Member 5) • MIR204 (MicroRNA 204) • RUNX2 (RUNX Family Transcription Factor 2)

4ms

Exosomes in HPV-Associated Cancers: From Biomarkers to Engineered Therapeutics. (PubMed, Cancers (Basel))

Exosomes hold great promise for integration into diagnostic and therapeutic workflows for HPV-related cancers. Future research should focus on resolving standardization issues, validating biomarkers in diverse cohorts, and optimizing engineered exosome platforms for targeted therapy.

4 months ago

Review • Journal

MIR21 (MicroRNA 21) • ANXA1 (Annexin A1) • HOTAIR (HOX Transcript Antisense RNA) • MIR99A (MicroRNA 99a) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • MIR204 (MicroRNA 204)