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GENE:

MIR203A (MicroRNA 203a)

News alerts, weekly reports and conference planners

12d

RNA-based therapies for colorectal cancer: targeting the β-catenin pathway via microbiota -modulated miRNAs. (PubMed, Front Mol Biosci)

It also covers microbiota-host interactions, including bidirectional links between gut microbes and miRNAs, effects on intestinal homeostasis, and microbial metabolites that alter miRNA expression. Recent advances in RNA-based therapeutic strategies and progress in clinical trials are included to frame the current translational relevance.

12 days ago

Review • Journal

MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • MIR21 (MicroRNA 21) • MIR200C (MicroRNA 200c) • MIR135B (MicroRNA 135b) • MIR145 (MicroRNA 145) • MIR203A (MicroRNA 203a)

17d

Phillyrin ameliorates sepsis via targeting microRNA-203a-mediated caspase-4/caspase-11/caspase-B downregulation to suppress endothelial pyroptosis. (PubMed, Phytomedicine)

These data identify the miR-203a-CASP4/11/B axis as a critical mediator of endothelial pyroptosis in sepsis. PHN attenuates sepsis by upregulating miR-203a to inhibit CASP4/11/B-dependent pyroptosis. Therefore, PHN warrants further investigation as a potential therapeutic agent for sepsis.

17 days ago

Journal

CASP4 (Caspase 4) • MIR203A (MicroRNA 203a) • CASP1 (Caspase 1)

25d

The role of PAQR3 in cancer progression - Molecular regulation, signaling pathways, and clinical implications: A review. (PubMed, Biomol Biomed)

Progesterone and adiponectin receptor 3 (PAQR3) is a Golgi-localized seven-transmembrane protein that anchors rapidly accelerated fibrosarcoma kinase (Raf) and suppresses rat sarcoma/rapidly accelerated fibrosarcoma/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (Ras/Raf/MEK/ERK) signaling, thereby influencing cellular proliferation, differentiation, and metastasis...These effects are modulated by upstream regulators, including microRNA-543 (miR-543), circular RNA 0043280/microRNA-203a-3p (circ_0043280/miR-203a-3p), microRNA-15b (miR-15b), human epidermal growth factor receptor 2 (HER2), 5-aza-2'-deoxycytidine (5-Aza-CdR), autophagy-related 7 (ATG7), and damage-specific DNA binding protein 2 (DDB2). In conclusion, PAQR3 functions as a tumor suppressor and holds potential as a prognostic biomarker. Targeting PAQR3-related pathways may provide new therapeutic opportunities.

25 days ago

Review • Journal

HER-2 (Human epidermal growth factor receptor 2) • TP53 (Tumor protein P53) • MIR543 (MicroRNA 543) • DDB2 (Damage Specific DNA Binding Protein 2) • ATG7 (Autophagy Related 7) • MIR15B (MicroRNA 15b) • MIR203A (MicroRNA 203a)

27d

Differential Circulating miRNA Responses to PM Exposure in Healthy and Diabetes Mellitus Patients: Implications for Lung Cancer Susceptibility. (PubMed, Int J Mol Sci)

In an independent clinical cohort, only miR-542-3p differed significantly between lung-cancer patients and healthy controls. These findings indicate that PM exposure reconfigures circulating miRNA, exosomal, and cytokine profiles, and that DM modifies these responses, highlighting miR-542-3p and miR-29a-3p as environmentally responsive and disease-relevant biomarker candidates.

27 days ago

Journal

CXCL8 (Chemokine (C-X-C motif) ligand 8) • MIR203A (MicroRNA 203a) • MIR29A (MicroRNA 29a) • MIR542 (MicroRNA 542)

Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)

The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.

1 month ago

Journal

TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)

MicroRNAs as Diagnostic and Prognostic Biomarkers in Melanoma and Non-Melanoma Skin Cancers: An Updated Review. (PubMed, Diagnostics (Basel))

Overall, current evidence supports miRNAs as promising diagnostic, prognostic, and predictive biomarkers in cutaneous oncology. Standardized methodologies and large-scale validation remain essential for their integration into routine clinical practice.

1 month ago

Review • Journal

BRAF (B-raf proto-oncogene) • MIR34A (MicroRNA 34a-5p) • MIR182 (MicroRNA 182) • MIR18A (MicroRNA 18a) • MIR31 (MicroRNA 31) • MIR375 (MicroRNA 375) • MIR128 (MicroRNA 128) • MIR145 (MicroRNA 145) • MIR181A1 (MicroRNA 181a-1) • MIR203A (MicroRNA 203a) • MIR205 (MicroRNA 205) • MIR383 (MicroRNA 383)

BRAF mutation

2ms

Oncogenic Function of miR-182-5p Versus Tumor-Suppressive Activities of miR-203, miR-150-5p, and miR-139-5p via Target Gene Regulation in Colon Cancer Metastasis. (PubMed, Iran J Pharm Res)

Mechanistically, miR-182-5p enhanced metastasis via ANLN and PDE4D regulation, whereas miR-203, miR-150-5p, and miR-139-5p suppressed metastasis through PDE4D, NEGR1, and ATP11A pathways, respectively. These results highlight the opposing roles of miR-182-5p and the tumor-suppressive miRNAs in CRC metastasis and suggest their potential as biomarkers and therapeutic targets.

2 months ago

Journal

MIR139 (MicroRNA 139) • MIR182 (MicroRNA 182) • ANLN (Anillin Actin Binding Protein) • MIR150 (MicroRNA 150) • MIR203A (MicroRNA 203a)

2ms

The Activation of miR-203a by SFRP4 Micropeptides Targets Epithelial-Mesenchymal Transition and Autophagy in Ovarian Cancer Stem Cells. (PubMed, Mol Carcinog)

Furthermore, miR-203a expression upon micropeptide treatment resulted in the increased levels of E-cad and decreased levels of N-cad, Snail and Twist, indicating reversal of EMT along with the significant reduction in migratory potential of ovarian CSCs. Our findings for the first time indicated the possible role of miR-203a in regulating autophagy in ovarian CSCs, and reactivation of miR-203a by SFRP4 micropeptides was sufficient to halt the autophagic machinery in ovarian CSCs.

2 months ago

Journal

MIR203A (MicroRNA 203a) • SFRP4 (Secreted frizzled-related protein 4)

3ms

MiR-125b-5p and miR-100-5p as Biomarkers and therapeutic targets for the prevention of particulate matter-induced non-smoker lung cancer. (PubMed, PLoS One)

These findings underscore the critical roles of miR-125b-5p and miR-100-5p in PM-associated lung cancer progression and their potential as biomarkers and therapeutic targets. This study highlights distinct mechanisms of lung carcinogenesis in smokers and non-smokers, providing a foundation for targeted interventions in PM-associated lung cancer.

3 months ago

Journal

MIR100 (MicroRNA 100) • MIR199A1 (MicroRNA 199a-1) • MIR199A (MicroRNA 199a) • MIR203A (MicroRNA 203a)

3ms

Circulating levels of microRNAs 126-5p, 150-5p, 214-3p, and 452-5p decrease following splenectomy in dogs with hemangiosarcoma. (PubMed, Am J Vet Res)

MiR-126-5p, miR-150-5p, miR-214-3p, and miR-452-5p all showed a decrease in expression at at least one timepoint following splenectomy. These miRNAs have been previously shown to have roles in angiogenesis and pathways known to be involved in the pathogenesis of hemangiosarcoma and may be prospective targets for a minimally invasive diagnostic panel for the presence of splenic hemangiosarcoma.

3 months ago

Journal

MIR543 (MicroRNA 543) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR494 (MicroRNA 494) • MIR497 (MicroRNA 497) • MIR150 (MicroRNA 150) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIR93 (MicroRNA 93)

3ms

Philadelphia chromosome-positive acute lymphoblastic leukemia: exploring microRNA-based strategies to improve outcomes. (PubMed, Mol Biol Rep)

Moreover, epigenetic silencing of miR-203 enhances BCR::ABL1 expression, further contributing to TKI resistance. These small regulatory RNAs consequently act for promising candidates both as therapeutic targets and as prognostic biomarkers, with the potential to fill treatment gaps that persist even in the TKI era.

3 months ago

Review • Journal • IO biomarker

ABL1 (ABL proto-oncogene 1) • BCL2 (B-cell CLL/lymphoma 2) • MIR17 (MicroRNA 17) • MIR18A (MicroRNA 18a) • MIR203A (MicroRNA 203a) • MIR20A (MicroRNA 20a)

ABL1 fusion