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    GENE:

    MIR200 (MicroRNA 200)

    i
    Other names: MIR200, MicroRNA 200
    Associations

    News

    Trials
    4d
    Role and underlying mechanisms of miR‑200 family in breast cancer (Review). (PubMed, Int J Oncol)
    Furthermore, members of the miR‑200 family have potential as diagnostic and prognostic biomarkers and are closely linked to chemotherapy resistance. The present review aims to provide novel insights and a theoretical foundation for the diagnosis, treatment, and deeper investigation of BC by comprehensively examining the functional mechanisms of the miR‑200.
    Review • Journal
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    MIR200B (MicroRNA 200b) • MIR200C (MicroRNA 200c) • MIR200A (MicroRNA 200a) • MIR141 (MicroRNA 141) • MIR200 (MicroRNA 200)
    11d
    Stage-Specific miRNA Profiling Reveals Key Regulators of EMT and EGFR-TKI Resistance in Gallbladder Cancer. (PubMed, Cancers (Basel))
    This study identifies distinct miRNA signatures associated with GBC initiation and progression, offering insights into the molecular pathogenesis of the disease. Furthermore, functional studies of the miRNAs implicated in EMT and EGFR-TKI resistance may be conducted using GBC cell lines to dissect the precise roles of key miRNAs and explore their potential as novel therapeutic targets in GBC.
    Journal
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    MIR361 (MicroRNA 361) • MIR195 (MicroRNA 195) • MIR200 (MicroRNA 200) • MIR423 (MicroRNA 423) • MIR574 (MicroRNA 574)
    11d
    Gastric Cancer Epithelial-Mesenchymal Transition-The Role of Micro-RNA. (PubMed, Cancers (Basel))
    Several EMT-related miRNAs show consistent associations with invasion, metastasis, peritoneal dissemination, prognosis, and chemoresistance, and many are detectable in circulation. Overall, EMT-related miRNAs orchestrate gastric cancer cell plasticity and tumor-microenvironment crosstalk and represent promising biomarker and therapeutic candidates that warrant validation in prospective, subtype-stratified, and translational studies.
    Review • Journal
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    MET (MET proto-oncogene, receptor tyrosine kinase) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR21 (MicroRNA 21) • MIR34A (MicroRNA 34a-5p) • TGFB1 (Transforming Growth Factor Beta 1) • MIR192 (MicroRNA 192) • MIR27A (MicroRNA 27a) • MIR17 (MicroRNA 17) • MIR23A (MicroRNA 23a) • MIR375 (MicroRNA 375) • MIR506 (MicroRNA 506) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • MIR106B (MicroRNA 106b) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR150 (MicroRNA 150) • MIR181A1 (MicroRNA 181a-1) • MIR200 (MicroRNA 200) • MIR204 (MicroRNA 204) • MIR218 (MicroRNA 218) • MIR26A1 (MicroRNA 26a-1) • MIR30A (MicroRNA 30a)
    27d
    Prognostic value of micro-RNA in ovarian cancer: a systematic review and meta-analysis. (PubMed, Front Oncol)
    Different miRNA families, particularly miR-200 and miR-30, have the potential to act as key biomarkers for ovarian cancer prognosis. https://www.crd.york.ac.uk/PROSPERO/view/CRD42024579585, identifier CRD42024579585.
    Retrospective data • Review • Journal
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    MIR200A (MicroRNA 200a) • MIR200 (MicroRNA 200)
    1m
    Coordinated inhibition of SOX9 and cell cycle progression by microRNA-200 restricts sebaceous gland fate specification. (PubMed, bioRxiv)
    The coordinated inhibition of the SOX9-dependent lipogenic program and the potent restriction of cell cycle progression, both mediated by miR-200s, collectively blocks SG specification. Taken together, this work reveals an unexpected specificity of miR-200 in restricting epithelial plasticity and elucidates a spatially defined SOX9 regulatory network essential for SG development.
    Journal
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    SOX9 (SRY-Box Transcription Factor 9) • MIR200 (MicroRNA 200)
    2ms
    The Redox-Adhesion-Exosome (RAX) Hub in Cancer: Lipid Peroxidation-Driven EMT Plasticity and Ferroptosis Defense with HNE/MDA Signaling and Lipidomic Perspectives. (PubMed, Antioxidants (Basel))
    By linking lipid peroxidation to ferroptosis defense and oxidative stress adaptation, the RAX hub aligns with the thematic focus of lipid metabolism and redox control in cancer progression. Collectively, the RAX framework may provide a conceptual basis for precision oncology by reframing metastasis and therapy resistance as emergent network properties.
    Review • Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • AXL (AXL Receptor Tyrosine Kinase) • MIR21 (MicroRNA 21) • GPX4 (Glutathione Peroxidase 4) • CDH2 (Cadherin 2) • YBX1 (Y-Box Binding Protein 1) • MIR210 (MicroRNA 210) • AIFM2 (Apoptosis Inducing Factor Mitochondria Associated 2) • MIR200 (MicroRNA 200)
    2ms
    Integrated transcriptomics and miRNA-mRNA network analysis reveals Kisspeptin-10 mediated regulation of EMT and apoptosis in glioblastoma. (PubMed, Comput Biol Chem)
    These findings highlight the diagnostic and therapeutic relevance of Kisspeptin-10-associated molecular regulation in GB. This is the first study to integrate transcriptomics, miRNA-mRNA network analysis, and experimental validation to elucidate Kisspeptin-10-mediated modulation of GB progression.
    Journal
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    CDC20 (Cell Division Cycle 20) • CDK1 (Cyclin-dependent kinase 1) • FABP5 (Fatty Acid Binding Protein 5) • MIR200 (MicroRNA 200) • MIR345 (MicroRNA 345)
    3ms
    Stage- and smoking-associated microRNA expression in lung adenocarcinoma. (PubMed, Transl Lung Cancer Res)
    Among the miRNA alterations associated with stage I adenocarcinoma in nonsmokers, we found alterations in all 5 miR-200 family members (miR-200b, miR-200a, miR-141, miR-429, and miR-200c). Our identification of miRNA alterations associated with early-stage lung adenocarcinoma in nonsmokers, especially alterations in the miR-200 family, suggests that these miRNAs may play a unique role in the early stages of lung carcinogenesis and progression in nonsmokers and that they may be useful as markers for the early detection of lung cancer.
    Journal
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    MIR200B (MicroRNA 200b) • MIR200C (MicroRNA 200c) • MIR429 (MicroRNA 429) • MIR200A (MicroRNA 200a) • MIR141 (MicroRNA 141) • MIR200 (MicroRNA 200)
    3ms
    MicroRNAs in Uterine Leiomyosarcoma: From Molecular Mechanisms to Clinical Applications. (PubMed, Int J Mol Sci)
    Emerging therapeutic approaches aim to restore the tumor-suppressive miRNAs or inhibit oncogenic ones using mimics or antagomiRs. Overall miRNAs represent critical regulators of uLMS pathogenesis and hold significant potential for precision diagnosis, prognostication, and targeted therapy, though larger validation studies and improved delivery systems are required before clinical translation.
    Review • Journal
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    MIR21 (MicroRNA 21) • MIR183 (MicroRNA 183) • MIR200 (MicroRNA 200)
    3ms
    The miR-200 Family in Non-Small-Cell Lung Cancer: Molecular Mechanisms, Clinical Applications, and Therapeutic Implications. (PubMed, Genes (Basel))
    Beyond summarizing associations, we interpret how this circuitry could inform biomarker development and rational combinations with targeted and immune therapies. Given heterogeneous study designs and non-standardized assays, translational claims remain provisional; we outline immediate priorities for assay harmonization and biomarker-stratified trials.
    Review • Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • MIR200A (MicroRNA 200a) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • ZEB2 (Zinc Finger E-Box Binding Homeobox 2) • MIR200 (MicroRNA 200)
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    PD-L1 expression
    3ms
    MicroRNA Expression in Breast Cancer Patients, an Integrative Review. (PubMed, J Surg Oncol)
    Notably, miRNAs such as miR-21, miR-155, and members of the miR-200 family show consistent associations with clinical parameters across multiple studies. The accessibility of miRNAs in blood and other body fluids, combined with their stability and specificity, positions them as valuable tools that could complement conventional diagnostic methods and support more personalized treatment strategies in breast cancer care.
    Review • Journal
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    MIR155 (MicroRNA 155) • MIR21 (MicroRNA 21) • MIR200 (MicroRNA 200)
    4ms
    Programmed death-ligand 1 mediates triple-negative breast cancer metastasis and stemness through ten-eleven translocation 3. (PubMed, Int J Biol Macromol)
    Furthermore, PD-L1 knockout is associated with improved tumor outcomes in orthotopic mouse models. Collectively, our findings identify a non-classical function of PD-L1 and TET3 as a critical epigenetic modifier that suppresses PD-L1-mediated EMT and breast cancer stemness during metastatic progression.
    Journal
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    PD-L1 (Programmed death ligand 1) • MIR106B (MicroRNA 106b) • MIR200 (MicroRNA 200)