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    GENE:

    MIR192 (MicroRNA 192)

    i
    Other names: MIR192, MicroRNA 192, Hsa-MiR-192-5p, Hsa-MiR-192-3p, Hsa-Mir-192, MIR192, Hsa-Mir-192-P1, MIMAT0004543, MIMAT0000222, MI0000234, MiRNA192, MIRN192, MiR-192, RF00130
    10d
    Gastric Cancer Epithelial-Mesenchymal Transition-The Role of Micro-RNA. (PubMed, Cancers (Basel))
    Several EMT-related miRNAs show consistent associations with invasion, metastasis, peritoneal dissemination, prognosis, and chemoresistance, and many are detectable in circulation. Overall, EMT-related miRNAs orchestrate gastric cancer cell plasticity and tumor-microenvironment crosstalk and represent promising biomarker and therapeutic candidates that warrant validation in prospective, subtype-stratified, and translational studies.
    Review • Journal
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    MET (MET proto-oncogene, receptor tyrosine kinase) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR21 (MicroRNA 21) • MIR34A (MicroRNA 34a-5p) • TGFB1 (Transforming Growth Factor Beta 1) • MIR192 (MicroRNA 192) • MIR27A (MicroRNA 27a) • MIR17 (MicroRNA 17) • MIR23A (MicroRNA 23a) • MIR375 (MicroRNA 375) • MIR506 (MicroRNA 506) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • MIR106B (MicroRNA 106b) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR150 (MicroRNA 150) • MIR181A1 (MicroRNA 181a-1) • MIR200 (MicroRNA 200) • MIR204 (MicroRNA 204) • MIR218 (MicroRNA 218) • MIR26A1 (MicroRNA 26a-1) • MIR30A (MicroRNA 30a)
    1m
    Assessment circulating micro-RNA-192 in Egyptian patients with non-viral liver cirrhosis and hepatocellular carcinoma. (PubMed, Discov Oncol)
    Serum microRNA-192 can predict decompensated liver cirrhosis and HCC with high sensitivity and specificity.
    Journal
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    AFP (Alpha-fetoprotein) • MIR192 (MicroRNA 192)
    2ms
    Lipid nanoparticle-encapsulated microRNA-192: An anti-inflammatory adjuvant that enhances vaccine efficacy in aged mice. (PubMed, Mol Ther Nucleic Acids)
    Additionally, miR-192 inhibited key components of the JAK-STAT signaling pathway, crucial for cytokine receptor signaling in myeloid cells. Overall, these findings indicate that miR-192 effectively suppresses harmful inflammatory responses, substantially enhancing vaccine efficacy, and highlight the therapeutic potential of the anti-inflammatory microRNA-based adjuvants for improving vaccination outcomes in the elderly.
    Preclinical • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • MIR192 (MicroRNA 192)
    3ms
    Circulating microRNA signatures for echinococcosis. (PubMed, Parasit Vectors)
    These results suggest that circulating miR-192-5p and miR-122-5p are serum signatures for the diagnosis and prognostic management of echinococcosis.
    Journal
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    MIR192 (MicroRNA 192) • AGO2 (Argonaute RISC Catalytic Component 2) • MIR122 (MicroRNA 122)
    3ms
    MicroRNA Signatures in Serous Ovarian Cancer: A Comparison of Prognostic Marker Targets in African Americans and Caucasians. (PubMed, Diseases)
    Pathway enrichment and gene ontology analyses (miRTargetLink2.0, Enrichr) revealed interconnected regulatory networks linking miR-192, miR-16-5p, miR-143-3p, and miR-20a-5p to ITGB1; miR-143-3p/miR-145-5p to BRAF; and miR-16-5p and miR-30c/d to TIMP3. Collectively, these findings identify distinct miRNA-mRNA regulatory signatures-particularly the miR-192-5p-ITGB1/TIMP3 axis-as potential clinically relevant biomarkers that may contribute to racial disparities and disease progression in ovarian cancer.
    Journal
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    BRAF (B-raf proto-oncogene) • MIR192 (MicroRNA 192) • MIR143 (MicroRNA 143) • MIR16 (MicroRNA 16) • MIR30D (MicroRNA 30d) • ITGB1 (Integrin Subunit Beta 1) • MIR145 (MicroRNA 145) • MIR20A (MicroRNA 20a) • MIR30C • TIMP3 (TIMP Metallopeptidase Inhibitor 3)
    3ms
    Identification and prognostic prediction of high-risk multiple myeloma by exosomal microRNA. (PubMed, Front Oncol)
    This integrative model effectively predicted 1-, 3-, and 5-year survival probabilities, thereby stratifying patients into distinct risk categories for enhanced clinical decision-making and personalized follow-up strategies. This research validates the diagnostic and prognostic utility of exosomal miRNA models in MM, emphasizing their discriminative and predictive capabilities.
    Journal
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    MIR192 (MicroRNA 192) • MIR193B (MicroRNA 193b) • MIR10B (MicroRNA 10b) • MIR148A (MicroRNA 148a) • MIR483 (MicroRNA 483) • MIRLET7B (MicroRNA Let-7b)
    4ms
    Identification of Novel Hepatic Target Genes of miR-192-5p. (PubMed, Genes Cells)
    These findings suggest that miR-192-5p exerts its tumor-suppressive function by inhibiting a novel gene network that may contribute to HCC progression. This study provides new insights into the molecular mechanisms underlying HCC heterogeneity and highlights miR-192-5p-regulated networks as potential therapeutic targets for HCC.
    Journal
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    MIR192 (MicroRNA 192) • EFEMP1 (EGF Containing Fibulin Extracellular Matrix Protein 1) • MIR194 (MicroRNA 194) • PPP1CA (Protein Phosphatase 1 Catalytic Subunit Alpha)
    4ms
    A robust ddPCR assay for the absolute quantification of miR-192-5p in hepatocellular carcinoma liquid biopsies. (PubMed, Clin Chem Lab Med)
    This LNA-optimized ddPCR assay resolves miRNA liquid biopsy barriers. The combinatorial model outperforms single biomarkers, offering a clinical tool for the precise quantification of HCC-specific miRNAs. Standardized workflows ensure reproducibility, and multicenter studies are needed for validation.
    Journal • Liquid biopsy
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    MIR192 (MicroRNA 192)
    4ms
    Bioinformatics-Based Analysis of the Screening and Evaluation of Potential Targets of FTY720 for the Treatment of Non-Small Cell Lung Cancer. (PubMed, Biology (Basel))
    Our research indicates that FTY720 may inhibit NSCLC via possible targets ZEB2 and S1PR1, further laying the theoretical foundation for the utilization of FTY720 in NSCLC treatment.
    Journal
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    CD8 (cluster of differentiation 8) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • MIR192 (MicroRNA 192) • CTBP1 (C-Terminal Binding Protein 1) • MIR132 (MicroRNA 132) • ZEB2 (Zinc Finger E-Box Binding Homeobox 2) • S1PR1 (Sphingosine-1-Phosphate Receptor 1)
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    fingolimod
    4ms
    Selected miRNAs in Urinary Extracellular Vesicles Show Promise for Early and Specific Diagnostics of Diabetic Kidney Disease. (PubMed, J Extracell Biol)
    The differentially expressed miRNAs did not cluster the control cohorts except for the chronic kidney disease cohort, which showed some clustering based on proteinuria status. Altogether, the miRNAs showed potential to identify early kidney function decline and may target key kidney cells, mRNAs, proteins and pathogenic mechanisms in DKD.
    Journal
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    MIR192 (MicroRNA 192) • MIR486-1 (MicroRNA 486-1) • MIR574 (MicroRNA 574)
    5ms
    MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis. (PubMed, Mol Oncol)
    These effects are dependent on the c-MYC/TERT/NFκB signaling molecular axis. BE patients and non-invasive EAC patients with high miR-196a expression could benefit from therapeutic interventions to prevent EMT or activation of the molecular pathway described in this study.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • TERT (Telomerase Reverse Transcriptase) • MIR192 (MicroRNA 192) • NFKBIA (NFKB Inhibitor Alpha 2) • MIR196A1 (MicroRNA 196a-1) • MIR196B (MicroRNA 196b) • VCP (Valosin Containing Protein)
    5ms
    The miR-192-EGR1/HOXB9 Loop Regulates Glioma Cell Stemness and Malignant Phenotypes by Promoting Their Mesenchymal Transition. (PubMed, J Cell Mol Med)
    MiR-192 could inhibit MT in glioma cells through the EGR1-HOXB9 loop. Thus, it reduces their stemness and abrogates their malignant phenotypes.
    Journal
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    MIR192 (MicroRNA 192) • EGR1 (Early Growth Response 1) • HOXB9 (Homeobox B9)