^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    MIR184 (MicroRNA 184)

    i
    Other names: MIR184, miR-184, MicroRNA 184, Hsa-Mir-184, Hsa-MiR-184, MIR184, MIMAT0000454, MI0000481, MIRN184, MiR-184, RF00657, EDICT
    4d
    Transcriptomic Insights into lncRNA-miRNA-mRNA Networks Regulating Angiogenesis and Metastasis in Prostate Cancer. (PubMed, BioTech (Basel))
    The LINC00261-miR-206-HIF1A axis may serve as a promising noninvasive biomarker and potential therapeutic target. The integration of computational and experimental data provides a strong rationale for the further functional validation of advanced PCa.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • MIR184 (MicroRNA 184) • MIR206 (MicroRNA 206) • MIR216A (MicroRNA 216a) • MIR183 (MicroRNA 183)
    2ms
    Saliva-based molecular diagnostics in oral squamous cell carcinoma (OSCC): a non-invasive frontier in oncology. (PubMed, Eur Arch Otorhinolaryngol)
    For translation into practice, further validation through large-scale trials, regulatory endorsement, and demonstration of cost-effectiveness remain essential. Nonetheless, saliva-based assays stand out as accessible, patient-centered tools with significant implications for the future of head and neck oncology.
    Review • Journal
    |
    IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • MIR21 (MicroRNA 21) • MIR184 (MicroRNA 184) • MIR31 (MicroRNA 31)
    2ms
    The dual role of miR-184 in cancer: a systematic review of context-dependent regulation. (PubMed, Mol Biol Rep)
    Key molecular targets and pathways influenced by miR-184, including c-MYC, caspases, and apoptotic signalling, were highlighted. Overall, these findings demonstrate that the function of miR-184 in cancer is context-dependent, shaped by tissue type, molecular environment, and cellular signalling networks.
    Review • Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • MIR184 (MicroRNA 184)
    3ms
    CAF-derived Exosomes Promote the Proliferation and Invasion of Pituitary Adenoma Cells via miR-184 Transfer. (PubMed, Brain Res Bull)
    Mechanistically, TLE1 was validated as a direct functional target of miR-184. In summary, our study reveals exosomal miR-184 as a key mediator of CAF-driven PA progression, highlighting its potential as a therapeutic target for PAs.
    Journal
    |
    MIR184 (MicroRNA 184)
    3ms
    RETRACTION: LncRNA FENDRR Attenuates Adriamycin Resistance via Suppressing MDR1 Expression Through Sponging HuR and miR-184 in Chronic Myelogenous Leukaemia Cells. (PubMed, FEBS Lett)
    However, due to the nature and extent of the duplications, the editors no longer have confidence in the results and conclusions reported in the paper. The co-authors, F. Zhang, H. Ni, X. Li and H. Liu did not respond to our notice of retraction.
    Journal
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • MIR184 (MicroRNA 184)
    |
    doxorubicin hydrochloride
    4ms
    Longitudinal multi-omics analyses of chemotherapy-induced peripheral neuropathy in response to taxanes. (PubMed, BMC Cancer)
    Our study offers valuable insights into the molecular mechanisms of CIPN in breast cancer patients treated with taxanes. By identifying key molecular markers and pathways, such as CREB and opioid signaling, we provide initial evidence for hypothesis generation and future research. While these findings are correlative and require further validation, they highlight potential biological mechanisms and serve as a basis for validating candidates as biomarkers or therapeutic targets.
    Journal
    |
    MIR184 (MicroRNA 184) • MIR31 (MicroRNA 31) • OPRM1 (Opioid Receptor Mu 1)
    |
    paclitaxel
    7ms
    Molecular and Genetic Pathogenesis of Oral Cancer: A Basis for Customized Diagnosis and Treatment. (PubMed, Biology (Basel))
    The knowledge of this molecular pathogenesis has not yet been translated into clinical practice, apart from the use of cetuximab, an EGFR antibody...Liquid biopsies, either resorting to circulating tumor cells, extracellular vesicles or cell-free nucleic acids, have the potential to bypass this problem, and have potential prognostic and staging value. We critically review the current knowledge on the molecular, genetic and epigenetic alterations in oral cancer, as well as the applications and challenges of liquid biopsies in its diagnosis, follow-up, and prognostic stratification.
    Review • Journal
    |
    TP53 (Tumor protein P53) • PTEN (Phosphatase and tensin homolog) • HRAS (Harvey rat sarcoma viral oncogene homolog) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CCND1 (Cyclin D1) • CDH1 (Cadherin 1) • FAT1 (FAT atypical cadherin 1) • ADAM9 (ADAM Metallopeptidase Domain 9) • MIR21 (MicroRNA 21) • MGAM (Maltase-Glucoamylase) • SOX17 (SRY-Box Transcription Factor 17) • MIR100 (MicroRNA 100) • MIR211 (MicroRNA 211) • MIR221 (MicroRNA 221) • MIR184 (MicroRNA 184) • MIR31 (MicroRNA 31) • MIR375 (MicroRNA 375) • CTTN (Cortactin) • MIR133B (MicroRNA 133b) • MIR138 (MicroRNA 138) • MIR200 (MicroRNA 200) • MIR203A (MicroRNA 203a) • MIR222 (MicroRNA 222)
    |
    Erbitux (cetuximab)
    7ms
    miR-184 in hepatocellular carcinoma: a promising therapeutic target. (PubMed, J Physiol Biochem)
    Furthermore, miR-184 shows promise as a diagnostic and prognostic biomarker in HCC because of its altered expression in cancerous tissues and blood. Its regulation through circRNAs and lncRNAs such as lncRNA UCA1, circ_0004913, circ-0001141, circ-102,166, LINC00205, and SNHG11 adds a layer of complexity, challenging us to delve deeper into the intricate mechanisms of miR-184, positioning it as a crucial target for potential therapeutic intervention.
    Review • Journal
    |
    FOXO3 (Forkhead box O3) • MIR184 (MicroRNA 184) • SNHG11 (Small Nucleolar RNA Host Gene 11)
    9ms
    Dysregulation of microRNA (miRNA) Due to Phthalate/Phthalate Metabolite Exposure and Associated Health Effects: A Narrative Review. (PubMed, J Xenobiot)
    Dysregulation of miR-34a, miR-15b, miR-141, miR-184, miR-19a, miR-125, and miR-let-7 were observed across several studies. More research involving human participants combined with mechanistic studies integrating mRNA target analysis would be beneficial in understanding the downstream effects of phthalate exposure on gene expression and grasping the broader biological implications.
    Review • Journal
    |
    MIR34A (MicroRNA 34a-5p) • MIR125 (MicroRNA 125) • MIR141 (MicroRNA 141) • MIR184 (MicroRNA 184) • MIR15B (MicroRNA 15b) • MIR19A (MicroRNA 19a)
    10ms
    Demethylated miR-184 regulates EPB41L5 and downregulates Notch signaling to inhibit metastasis in colorectal cancer. (PubMed, J Mol Histol)
    These findings suggest that demethylated miR-184 inhibits CRC metastasis by targeting the EPB41L5/Notch signaling axis. This regulatory pathway may serve as a novel prognostic biomarker and therapeutic target, with potential clinical implications for the prevention and treatment of metastatic colorectal cancer.
    Journal
    |
    MIR184 (MicroRNA 184)
    11ms
    N6-methyladenosine-mediated upregulation of H19 promotes resistance to bortezomib by modulating the miR-184/CARM1 axis in multiple myeloma. (PubMed, Clin Exp Med)
    In conclusion, rescue trials have validated the significance of the METTL3/H19/miR-184/CARM1 pathway in determining the susceptibility of cells to BTZ. Consequently, directing efforts toward this pathway could prove to be a powerful approach for enhancing the effectiveness of BTZ for MM therapy.
    Journal
    |
    MIR184 (MicroRNA 184) • METTL3 (Methyltransferase Like 3)
    |
    bortezomib
    12ms
    Novel Detection and Clinical Utility of Serum-Derived Extracellular Vesicle in Angiosarcoma. (PubMed, Acta Derm Venereol)
    Furthermore, a gene analysis predicted that the target gene set of microRNAs might affect the regulation of TP53 via the epigenetic regulation of MECP2. Taken together, these 4 extracellular vesicle-associated microRNAs in circulation serve as a promising liquid biomarker to identify angiosarcoma patients and trace disease progression.
    Journal
    |
    TP53 (Tumor protein P53) • MIR184 (MicroRNA 184) • MIR570 (MicroRNA 570)