^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    MIR181C (MicroRNA 181c)

    i
    Other names: MIR181C, MicroRNA 181c, Hsa-MiR-181c-5p, Hsa-MiR-181c-3p, Hsa-Mir-181c, MIRN181C, Hsa-Mir-181-P1c, MIMAT0004559, MIMAT0000258, MI0000271, Mir-181c, RF00076
    Associations

    News

    Trials
    4ms
    RETRACTION: Downregulation of Long Noncoding RNA LUCAT1 Suppresses the Migration and Invasion of Bladder Cancer by Targeting miR-181c-5p. (PubMed, Biomed Res Int)
    [This retracts the article DOI: 10.1155/2020/4817608.].
    Journal
    |
    LUCAT1 (Lung Cancer Associated Transcript 1) • MIR181C (MicroRNA 181c)
    7ms
    Vitamin D-regulated miRNA expression in tumoral and normal adjacent tissue of localized gastric cancer patients: the impact on survival and time to relapse. (PubMed, Transl Cancer Res)
    Additionally, miRNA expression patterns in NAT may indicate a predisposition to tumor recurrence. The study concludes that miRNA dysregulation in non-neoplastic gastric mucosa suggests these tissues may be cancer-prone environments.
    Journal
    |
    MIR143 (MicroRNA 143) • MIR106B (MicroRNA 106b) • MIR145 (MicroRNA 145) • MIR181A1 (MicroRNA 181a-1) • MIR181B1 (MicroRNA 181b-1) • MIR181C (MicroRNA 181c) • MIR99B (MicroRNA 99b)
    7ms
    Unlocking temozolomide resistance in glioblastoma: the pivotal role of MicroRNAs and in-silico insights. (PubMed, Med Oncol)
    While the in-silico analysis elucidates cell line-based resistance mechanisms. This integrative approach provides a foundation for advancing miRNA-based strategies to overcome TMZ resistance.
    Review • Journal
    |
    MGMT (6-O-methylguanine-DNA methyltransferase) • MIR142 (MicroRNA 142) • MIR181C (MicroRNA 181c) • MIR195 (MicroRNA 195)
    |
    temozolomide
    8ms
    Ovarian cancer cell heterogeneity and paclitaxel response in vitro 2D and 3D cancer cell models and xenograft growth in the chicken chorioallantoic membrane (CAM). (PubMed, Biochem Biophys Res Commun)
    Tumors derived from residual cells exposed to paclitaxel and grafted onto the CAM displayed organizational patterns distinct from those of the control tumors. These findings strongly support the notion that defining tumor phenotypic characteristics could aid in developing more effective therapeutic strategies and new drug targets.
    Preclinical • Journal • IO biomarker
    |
    TP53 (Tumor protein P53) • KIT (KIT proto-oncogene, receptor tyrosine kinase) • BCL2 (B-cell CLL/lymphoma 2) • CD44 (CD44 Molecule) • CD24 (CD24 Molecule) • CASP8 (Caspase 8) • MCAM (Melanoma Cell Adhesion Molecule) • MIR221 (MicroRNA 221) • MIR17 (MicroRNA 17) • TNFRSF10B (TNF Receptor Superfamily Member 10b) • MIR181C (MicroRNA 181c) • MIR26A1 (MicroRNA 26a-1)
    |
    paclitaxel
    10ms
    The role of CPLX2 and SNAP25 genes in the rehabilitation of colorectal cancer liver metastases: CPLX2, SNAP25 in colorectal cancer liver metastases. (PubMed, Medicine (Baltimore))
    The results confirmed that CPLX2 and SNAP25 positively regulated the phosphatidylinositol 3 kinase-AKT signaling pathway and promoted the progression of liver metastasis of colorectal cancer. CPLX2 and SNAP25 genes are overexpressed in colorectal cancer liver metastasis and may serve as important molecular targets.
    Journal
    |
    MIR206 (MicroRNA 206) • CPLX2 (Complexin 2) • MIR181B1 (MicroRNA 181b-1) • MIR181C (MicroRNA 181c)
    11ms
    High-throughput 3D spheroid screens identify microRNA sensitizers for improved thermoradiotherapy in locally advanced cancers. (PubMed, Mol Ther Nucleic Acids)
    Additionally, differential expression of miR-27a, miR-221, and miR-224 in treatment-sensitive versus treatment-resistant patients indicated their predictive biomarker potential for treatment response of cervical cancer patients. Conclusively, this study has identified 18 promising miRNAs for the development of sensitizers for thermoradiotherapy and may provide potential biomarkers for predicting treatment response in locally advanced cancers.
    Journal
    |
    RAD51 (RAD51 Homolog A) • MIR221 (MicroRNA 221) • MIR27A (MicroRNA 27a) • MIR1293 (MicroRNA 1293) • MIR16 (MicroRNA 16) • MIR181C (MicroRNA 181c) • MIR224 (MicroRNA 224)
    1year
    Disulfidptosis-related gene signatures as prognostic biomarkers and predictors of immunotherapy response in HNSCC. (PubMed, Front Immunol)
    The prognostic model effectively predicts HNSCC outcomes, with better prognosis in the low-risk group. DSTN upregulation promotes tumor growth, and its knockout inhibits proliferation, migration, and invasion.
    Journal • Tumor mutational burden • Gene Signature • IO biomarker
    |
    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • SLC3A2 (Solute Carrier Family 3 Member 2) • IGF2 (Insulin-like growth factor 2) • IGFL2-AS1 (IGFL2 Antisense RNA 1) • LUCAT1 (Lung Cancer Associated Transcript 1) • MIR181C (MicroRNA 181c)
    1year
    Metastatic melanoma: An integrated analysis to identify critical regulators associated with prognosis, pathogenesis and targeted therapies. (PubMed, PLoS One)
    MiRNAs analysis revealed hsa-miR-181c-5p, hsa-miR-30b-3p, hsa-miR-3680-3P, hsa-miR-4659a-3p, hsa-miR-4687-3P, and hsa-miR-6808-3P could regulate the hub genes, whereas RP11-553K8.5 and SRP14-AS1 were identified as the top significant lncRNA. The items recognized in the current study can be used as potential biomarkers for diagnostic, predictive, and might helpful to develop targeted combined therapies.
    Journal
    |
    SMAD4 (SMAD family member 4) • ICAM1 (Intercellular adhesion molecule 1) • SOX2 • TCF3 (Transcription Factor 3) • CXCL11 (C-X-C Motif Chemokine Ligand 11) • CDK2 (Cyclin-dependent kinase 2) • MIR30B (MicroRNA 30b) • STAT1 (Signal Transducer And Activator Of Transcription 1) • CDK1 (Cyclin-dependent kinase 1) • MITF (Melanocyte Inducing Transcription Factor) • NANOG (Nanog Homeobox) • MIR181C (MicroRNA 181c) • SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit)
    1year
    LUCAT1-Mediated Competing Endogenous RNA (ceRNA) Network in Triple-Negative Breast Cancer. (PubMed, Cells)
    Indeed, LUCAT1 silencing led to mitigated cell growth, migration, and stem-like features in TNBC. This work sheds light on the LUCAT1 ceRNA network in TNBC and implies its involvement in TNBC growth and progression.
    Journal
    |
    BCL2 (B-cell CLL/lymphoma 2) • ABCB1 (ATP Binding Cassette Subfamily B Member 1) • YAP1 (Yes associated protein 1) • MIR200C (MicroRNA 200c) • LRP1 (LDL Receptor Related Protein 1) • MIR199A (MicroRNA 199a) • MIR375 (MicroRNA 375) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • ADAM10 (ADAM Metallopeptidase Domain 10) • LUCAT1 (Lung Cancer Associated Transcript 1) • MIR181C (MicroRNA 181c)
    over1year
    MicroRNA Signatures Associated with Basal Cell Carcinoma Subtypes. (PubMed, JID Innov)
    Receiver operating characteristic analysis demonstrated excellent capacity of these miRs to discriminate between BCC and control skin (area under the curve, 0.94-0.98), whereas the capacity to discriminate between superficial and invasive subtypes was less robust (area under the curve, 0.7-0.8). Future prospective studies may determine the utility of these miRs as diagnostic biomarkers to guide biopsy and treatment of BCC.
    Journal
    |
    MIR16 (MicroRNA 16) • MIR145 (MicroRNA 145) • MIR181C (MicroRNA 181c) • MIR22 (MicroRNA 22) • MIR30C • MIR383 (MicroRNA 383) • MIR708 (MicroRNA 708)
    over1year
    miR-181c-5p/DERL1 pathway controls breast cancer progression mediated by TRAF6-linked K63 ubiquitination of AKT. (PubMed, Cancer Cell Int)
    Our data confirm that mediation of the miR-181c-5p/DERL1 pathway by TRAF6-linked AKT K63 ubiquitination holds one of the clues to set our focus on toward meeting the therapeutic goals of BRCA.
    Journal • BRCA Biomarker
    |
    BRCA (Breast cancer early onset) • DERL1 (Derlin 1) • ERLIN1 (ER Lipid Raft Associated 1) • MIR181C (MicroRNA 181c) • TRAF6 (TNF Receptor Associated Factor 6)
    almost2years
    Downregulation of miR-181c-5p in Alzheimer's disease weakens the response of microglia to Aβ phagocytosis. (PubMed, Sci Rep)
    Additionally, miR-181c-5p downregulation alleviated the phosphorylation of P38 in Aβ1-42-induced SH-SY5Y cells. In conclusion, miR-181c-5p improves the phagocytosis of Aβ by microglial cells in AD patients, thereby reducing neuroinflammation.
    Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL1B (Interleukin 1, beta) • MIR181C (MicroRNA 181c)