MIR152 (MicroRNA 152)

Correlation and regression analyses validated the proposed ceRNA interactions and their significant association with advanced cancer stage. A high-risk score from the H19/miR-152/DNMT1 axis was prognostic only in thyroid cancer (HR = 2.97).

miR-330-5p was shown to affect the proliferation, invasion, and migration of gastric cancer cells by mediating ITGA5 through a mechanism possibly associated with the regulation of the FAK/AKT signaling pathway.

Therefore, these findings suggest that miRNAs may serve as predictive biomarkers and potential therapeutic targets in the management of breast cancer.

In individuals with HCV genotype 4, the interplay of miRNA152, DNMT1, GSTP1, and CDH1 may contribute to the pathogenesis of HCC. These indicators demonstrate potential roles as therapeutic targets and noninvasive prognostic biomarkers for HCV-related liver disease.

Importantly, this miRNA confers resistance to cisplatin-induced, RIPK1-mediated cell death, promoting gastric cancer cell survival and proliferation. Our study defines the miR-148/152 family as critical oncogenic drivers that promote cancer cell survival and chemoresistance by directly suppressing RIPK1 expression. These findings highlight this miRNA family as a promising therapeutic target to overcome cell death evasion in cancer.

Cytological experiments demonstrated that PAPSS2 knockdown enhanced the proliferation, migration, and invasion of HCT116 and HT-29 cells. Our study suggests that PAPSS2 acts as a promising diagnostic and prognostic biomarker, which facilitates malignant progression in part through its regulation of the p53 signaling pathway.

The findings of this study suggest that miR-214 and miR-433 can downregulate PTEN whereas miR-100 and miR-152 may have a tumour suppressive role like PTEN. Thus, the signature miR network has the potential to become a diagnostic and prognostic biomarker.

The Editor apologizes to the readership for any inconvenience caused. [Oncology Reports 37: 1227-1234, 2017; DOI: 10.3892/or.2016.5290].

Therapeutically, restoring miR-152 expression via mimics, demethylating agents, or nanocarrier-based delivery systems shows promise in preclinical studies for reversing chemoresistance and inhibiting metastasis. This review synthesizes miR-152's upstream regulators, downstream targets, and clinical potential, offering a roadmap for its exploitation in precision oncology.

The lncRNA CASC2/miR-152-3p axis played a critical role in mediating the formation of DVT.

[This retracts the article DOI: 10.21037/tcr-20-1736.].

In addition, wilms tumor 1-associated protein (WTAP) mediated m6A modification enhances the stability of PDIA3P1 through Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) dependent recognition. Taken together, these findings reveal the key role of PDIA3P1 regulates glycolysis-H4K8la-BMP7 axis in the progression of ESCC and provides new insights into the interplay between metabolic reprogramming and epigenetic regulation.