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    GENE:

    MIR148A (MicroRNA 148a)

    i
    Other names: MicroRNA 148a, Hsa-MiR-148a-5p, Hsa-MiR-148a-3p, MicroRNA 148, Hsa-Mir-148a, Hsa-Mir-148, MIRN148A, Mir-148a, MIRN148, MIR148A
    Associations

    News

    Trials
    11d
    Gastric Cancer Epithelial-Mesenchymal Transition-The Role of Micro-RNA. (PubMed, Cancers (Basel))
    Several EMT-related miRNAs show consistent associations with invasion, metastasis, peritoneal dissemination, prognosis, and chemoresistance, and many are detectable in circulation. Overall, EMT-related miRNAs orchestrate gastric cancer cell plasticity and tumor-microenvironment crosstalk and represent promising biomarker and therapeutic candidates that warrant validation in prospective, subtype-stratified, and translational studies.
    Review • Journal
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    MET (MET proto-oncogene, receptor tyrosine kinase) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR21 (MicroRNA 21) • MIR34A (MicroRNA 34a-5p) • TGFB1 (Transforming Growth Factor Beta 1) • MIR192 (MicroRNA 192) • MIR27A (MicroRNA 27a) • MIR17 (MicroRNA 17) • MIR23A (MicroRNA 23a) • MIR375 (MicroRNA 375) • MIR506 (MicroRNA 506) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • MIR106B (MicroRNA 106b) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR150 (MicroRNA 150) • MIR181A1 (MicroRNA 181a-1) • MIR200 (MicroRNA 200) • MIR204 (MicroRNA 204) • MIR218 (MicroRNA 218) • MIR26A1 (MicroRNA 26a-1) • MIR30A (MicroRNA 30a)
    12d
    Mechanism of action of MiR-330-5p targeting ITGA5 in the regulation of proliferation, migration, and invasionof gastric cancer. (PubMed, BMC Cancer)
    miR-330-5p was shown to affect the proliferation, invasion, and migration of gastric cancer cells by mediating ITGA5 through a mechanism possibly associated with the regulation of the FAK/AKT signaling pathway.
    Journal
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    MIR152 (MicroRNA 152) • ITGA5 (Integrin Subunit Alpha 5) • MIR148A (MicroRNA 148a) • MIR148B (MicroRNA 148b) • MIR26A1 (MicroRNA 26a-1) • MIR330 (MicroRNA 330)
    21d
    Magnolia officinalis Lignans induce apoptosis and epigenetic reprogramming via the miR-148a-3p/DNMT-1/UTF-1 axis in pancreatic cancer cells. (PubMed, Fitoterapia)
    These interactions suggest that MRW constituents' function as non-nucleoside DNMT-1 inhibitors and ROS-immune modulators that disrupt oncogenic feedback loops and re-activate apoptotic pathways. Collectively, these findings identify MRW as a multi-target phytomedicine integrating ROS-mediated oxidative stress, epigenetic remodeling, and immune-apoptotic signaling, supporting its translational potential as a low-toxicity adjunct strategy to conventional pancreatic cancer therapies.
    Journal
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    IL6 (Interleukin 6) • BIRC5 (Baculoviral IAP repeat containing 5) • DNMT1 (DNA methyltransferase 1) • MIR148A (MicroRNA 148a)
    1m
    From Tissue Archives to Liquid Biopsy: Transfer Learning for MicroRNA-Based Lung Cancer Diagnosis. (PubMed, Anal Chem)
    The transfer-learned model ultimately achieves a high classification accuracy of 91.5% and a sensitivity of 92.2% on the clinical serum test set. We envision that the approach offers a cost-effective solution for high-accuracy liquid biopsy with limited samples.
    Journal • Liquid biopsy
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    MIR139 (MicroRNA 139) • MIR30D (MicroRNA 30d) • MIR148A (MicroRNA 148a)
    1m
    The miR-148/152 Family Suppresses Apoptosis and Necroptosis for Cancer Evasion Through Direct RIPK1 Repression. (PubMed, Cell Biol Int)
    Importantly, this miRNA confers resistance to cisplatin-induced, RIPK1-mediated cell death, promoting gastric cancer cell survival and proliferation. Our study defines the miR-148/152 family as critical oncogenic drivers that promote cancer cell survival and chemoresistance by directly suppressing RIPK1 expression. These findings highlight this miRNA family as a promising therapeutic target to overcome cell death evasion in cancer.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • CASP3 (Caspase 3) • CASP8 (Caspase 8) • MIR152 (MicroRNA 152) • RIPK1 (Receptor Interacting Serine/Threonine Kinase 1) • MIR148A (MicroRNA 148a)
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    cisplatin
    2ms
    Retraction: MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase. (PubMed, Oncol Res)
    [This retracts the article DOI: 10.3727/096504017X14850134190255.].
    Journal
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    MIR148A (MicroRNA 148a)
    2ms
    Coordinated Expression and Methylation of microRNAs: Role in Common Biological Processes and Signaling Pathways in Breast Cancer (PubMed, Mol Biol (Mosk))
    Indeed, for the pairs miR-127-5p/miR-125b-5p, miR-148a-3p/miR-125b-5p, miR-148a-3p/miR-132-3p, and miR-34b-3p/miR-193a-5p, common mRNA targets and involvement in biological processes, including pathways associated with epigenetic regulation, proliferation, and metastasis, were revealed. The miRNA-mRNA regulatory network constructed involving DNMTs and EZH2 highlights their potential role in breast cancer progression and demonstrates diagnostic and prognostic significance.
    Journal
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    MIR132 (MicroRNA 132) • MIR127 (MicroRNA 127) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2) • MIR148A (MicroRNA 148a) • MIR193A (MicroRNA 193a) • MIR34B (MicroRNA 34b)
    3ms
    MicroRNA-Mediated Metabolic Control in HCC: From Molecular Networks to Therapy. (PubMed, Exp Cell Res)
    This study aims to elucidate the role of microRNAs in regulating metabolic pathways in HCC by delineating numerous miRNA-target interactions involved in glycolysis, lipid, amino acid, and nucleotide metabolism. This knowledge will enable us to identify novel diagnostic biomarkers and therapeutic targets for prognosis and to explore effective novel precision treatment strategies.
    Review • Journal
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    MIR21 (MicroRNA 21) • MIR27A (MicroRNA 27a) • MIR30B (MicroRNA 30b) • MIR122 (MicroRNA 122) • MIR148A (MicroRNA 148a)
    3ms
    Regulatory roles of non-coding and exosomal RNAs in colorectal cancer: spotlight on angiogenesis. (PubMed, Clin Exp Med)
    This review integrates current findings on the complex interactions between miRNAs, lncRNAs, circRNAs, and exosomal ncRNAs in CRC angiogenesis. Understanding these molecular regulators highlights their potential as novel diagnostic biomarkers and therapeutic targets, which may lead to new targeted treatments that improve CRC patient outcomes by controlling angiogenesis and metastatic spread.
    Review • Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • HNF1A (HNF1 Homeobox A) • MIR148A (MicroRNA 148a) • MIR181A1 (MicroRNA 181a-1)
    3ms
    Identification of anoikis-related genes and immune infiltration characteristics in Sjögren's syndrome based on machine learning. (PubMed, Front Med (Lausanne))
    These genes likely mediate their effects by influencing immune cell infiltration, participating in immune regulation, and modulating inflammatory responses. Our findings offer new insights into drug selection and immunotherapeutic strategies for SS.
    Journal • IO biomarker
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    CXCL10 (Chemokine (C-X-C motif) ligand 10) • BIRC3 (Baculoviral IAP repeat containing 3) • S100A9 (S100 Calcium Binding Protein A9) • MIR30B (MicroRNA 30b) • IFI27 (Interferon Alpha Inducible Protein 27) • IL15 (Interleukin 15) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MAPK3 (Mitogen-Activated Protein Kinase 3) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR483 (MicroRNA 483) • MIR486-1 (MicroRNA 486-1)
    3ms
    Identification and prognostic prediction of high-risk multiple myeloma by exosomal microRNA. (PubMed, Front Oncol)
    This integrative model effectively predicted 1-, 3-, and 5-year survival probabilities, thereby stratifying patients into distinct risk categories for enhanced clinical decision-making and personalized follow-up strategies. This research validates the diagnostic and prognostic utility of exosomal miRNA models in MM, emphasizing their discriminative and predictive capabilities.
    Journal
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    MIR192 (MicroRNA 192) • MIR193B (MicroRNA 193b) • MIR10B (MicroRNA 10b) • MIR148A (MicroRNA 148a) • MIR483 (MicroRNA 483) • MIRLET7B (MicroRNA Let-7b)
    3ms
    The SNHG3/miR-148a-3p axis-mediated high expression of DNMT1 is correlated with poor prognosis and tumor immune infiltration in hepatocellular carcinoma. (PubMed, J Gastrointest Oncol)
    DNMT1 overexpression could serve as a biomarker for poor prognosis, and is closely associated with enhanced immune cell infiltration and immune checkpoint expression in HCC. These findings suggest that DNMT1 may serve as a potential therapeutic target for both conventional treatment and immunotherapy in HCC patients.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • AFP (Alpha-fetoprotein) • CD4 (CD4 Molecule) • DNMT1 (DNA methyltransferase 1) • MIR148A (MicroRNA 148a)
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    AFP elevation