^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    MIR140 (MicroRNA 140)

    i
    Other names: MIR140, MicroRNA 140, Hsa-MiR-140-3p, Hsa-MiR-140-5p, Hsa-Mir-140, MIRN140, Hsa-Mir-140-P1-V1_pre, Hsa-Mir-140-P1-V2_pre, MIMAT0000431, MIMAT0004597, MI0000456, MiRNA140, MIR-140, Mir-140, RF00678, SEDN
    Associations

    News

    Trials
    11d
    Hybrid lipoplex co-delivering siPD-L1/miR-140-5p reverses T cell exhaustion via post-transcriptional regulation for in situ photothermal vaccination. (PubMed, Nanoscale)
    This combination treatment mitigated MPTT-induced PD-L1 upregulation and alleviated T cell exhaustion. Collectively, these findings demonstrate a synergistic strategy that enhances photothermal immunotherapy through the co-delivery of siRNA and miRNA to suppress PD-L1, enabling potent and systemic antitumor responses.
    Journal
    |
    MIR140 (MicroRNA 140)
    18d
    LncRNA TMPO-AS1 aggravates the cisplatin resistance in cervical cancer via miR-140-5p/DNMT1 axis-mediated DNA methylation of KLK10. (PubMed, Med Oncol)
    In vivo experiments further demonstrated that silencing TMPO-AS1 inhibited tumor growth. This study unveils a novel TMPO-AS1/miR-140-5p/DNMT1/KLK10 regulatory axis that plays a critical role in cisplatin resistance in CC, providing a potential therapeutic target for overcoming chemoresistance.
    Journal
    |
    DNMT1 (DNA methyltransferase 1) • KLK10 (Kallikrein Related Peptidase 10) • MIR140 (MicroRNA 140) • TMPO-AS1 (TMPO Antisense RNA 1)
    |
    cisplatin
    1m
    N6-Methyladenosine Modification of circIST1 Promotes Hypoxia-Inducible Factor α-mediated Glycolysis and Progression in Hepatocellular Carcinoma. (PubMed, MedComm (2020))
    Furthermore, we identify methyltransferase-like 3 (METTL3)-dependent m6A modification as a critical regulator of circIST1 stability. Collectively, our findings uncover a novel m6A-circIST1-miR-140-3p/miR-182-HIF-1α regulatory axis that underlies metabolic reprogramming in HCC, positioning circIST1 as a promising therapeutic target for HCC metabolic intervention.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • MIR182 (MicroRNA 182) • METTL3 (Methyltransferase Like 3) • MIR140 (MicroRNA 140)
    2ms
    Origin recognition complex subunit 1 functions as an oncogenic driver and therapeutic target in cancer. (PubMed, Discov Oncol)
    ORC1 represents a promising therapeutic target, as its inhibition induces replication stress, cell cycle arrest, and enhances sensitivity to existing chemotherapeutic agents. Future research should focus on developing specific ORC1 inhibitors and exploring their synergistic potential with immunotherapy and targeted therapies.
    Review • Journal • IO biomarker
    |
    IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • SLC7A11 (Solute Carrier Family 7 Member 11) • ETV4 (ETS Variant Transcription Factor 4) • MIR140 (MicroRNA 140) • ORC1 (Origin Recognition Complex Subunit 1) • XIST (X Inactive Specific Transcript)
    2ms
    MicroRNA Profiling Identifies Diagnostic and Prognostic Markers in Pediatric Sarcoma. (PubMed, Cancers (Basel))
    Collectively, these findings demonstrate that distinct miRNA profiles can differentiate pediatric sarcoma types and subtypes and offer clinically relevant insights into tumor biology, prognosis, and potential diagnostic application.
    Journal
    |
    MIR206 (MicroRNA 206) • MIR140 (MicroRNA 140)
    3ms
    Extracellular Particles to Track Cancer Biomarkers from Tissue to Biofluids. (PubMed, J Dent Res)
    Notably, saliva emerged as the most promising biofluid for GC diagnosis, achieving superior receiver-operating characteristic curve values compared with plasma and tissue. This study highlights the role of BEST and MBA in advancing single-EVP analysis and elucidating EVP trafficking, paving the way for future diagnostic applications of EVP cargo.
    Journal
    |
    MIR140 (MicroRNA 140)
    4ms
    Multidimensional analysis of hsa-miR-140-3p and CKS1B correlation via the MAPK/ERK pathway in lung adenocarcinoma progression. (PubMed, Discov Oncol)
    A nomogram integrating CKS1B expression with clinical parameters effectively predicted 3- and 5-year survival probabilities, offering a tool for personalized risk assessment. In conclusion, our findings position CKS1B as a key factor in LUAD progression and suggest that targeting MAPK/ERK signaling could enhance the efficacy of immunotherapy and overcome chemoresistance.
    Journal • Tumor mutational burden • IO biomarker
    |
    TMB (Tumor Mutational Burden) • CDH1 (Cadherin 1) • CDH2 (Cadherin 2) • MIR140 (MicroRNA 140)
    4ms
    Exosomal miR-140-3p produced by bone marrow stromal cells affects acute myeloid leukemia cell growth and apoptosis by targeting SUZ12. (PubMed, Leuk Res)
    Moreover, SUZ12 polycomb repressive complex 2 subunit (SUZ12) was directly targeted by miR-140-3p, overexpression or inhibition of SUZ12 in AML cells partially counteracted miR-140-3p agomir or antagomir-mediated cellular effects, respectively. Our study suggested that the BMSCs-derived exosomal miR-140-3p, rather than miR-142-5p and miR-142-3p, has a regulatory effect on the growth and apoptosis of AML cells by targeting SUZ12.
    Journal
    |
    CASP3 (Caspase 3) • MIR142 (MicroRNA 142) • MIR140 (MicroRNA 140) • SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit)
    5ms
    LncRNA PSMA-AS1 affects glioma cell metastasis through mediating pyroptosis via miR-140-3p/SRSF10 axis. (PubMed, Cytotechnology)
    In addition, SRSF10 is a downstream binding target of miR-140-3p, and inhibition of SRSF10 also promoted pyroptosis and inhibited glioma cells proliferation and metastasis. In conclusion, our results confirmed that PSMA1-AS1 affects glioma cell proliferation and metastasis by regulating pyroptosis through miR-140-3p/SRSF10 axis, suggesting that LncRNA PSMA1-AS1 may be a potential target for glioma.
    Journal
    |
    PSMA1 (Proteasome 20S Subunit Alpha 1) • MIR140 (MicroRNA 140)
    |
    PSMA1 expression
    5ms
    Comparative study on the protective effect of dexrazoxane and blueberry extract against doxorubicin-induced cardiotoxicity in rats. (PubMed, Sci Rep)
    The histopathological assessment of myocardial damage provided supportive evidence for the biochemical results obtained. In conclusion, the BB extract (80.0 mg/kg) can attenuate the DOX-induced oxidative stress, and it has the potential to be developed as an adjunct against DOX-induced cardiotoxicity in cancer patients who undergo anthracycline chemotherapy.
    Clinical • Preclinical • Journal
    |
    NFE2L2 (Nuclear Factor, Erythroid 2 Like 2) • MIR140 (MicroRNA 140) • SIRT2 (Sirtuin 2)
    |
    doxorubicin hydrochloride • dexrazoxane
    6ms
    The Role of Epigenetic Biomarkers as Diagnostic, Predictive and Prognostic Factors in Colorectal Cancer. (PubMed, Cancers (Basel))
    Selected lncRNAs, including THOR and LINC01094, have also demonstrated significant prognostic value. Despite these advances, challenges persist, including inconsistent reporting, limited external validation, and a lack of replication by independent research groups.
    Review • Journal
    |
    ERCC1 (Excision repair cross-complementation group 1) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • MIR21 (MicroRNA 21) • GAS6 (Growth arrest specific 6) • MIR211 (MicroRNA 211) • IGFBP3 (Insulin-like growth factor binding protein 3) • LINC01094 (Long Intergenic Non-Protein Coding RNA 1094) • MIR140 (MicroRNA 140) • MIR150 (MicroRNA 150) • MIR215 (MicroRNA 215) • MIR675 (MicroRNA 675) • SDC2 (Syndecan 2) • SEPTIN9 (Septin 9) • SNHG14 (Small Nucleolar RNA Host Gene 14) • ASB16-AS1 (ASB16 Antisense RNA 1)
    7ms
    Regulatory Roles of miR-155-5p, miR-21-5p, miR-93-5p, and miR-140-5p in Breast Cancer Progression. (PubMed, Curr Issues Mol Biol)
    This case-control study, aimed to evaluate the expression profiles of specific microRNAs (miRNAs)-miR-155-5p, miR-21-5p, miR-93-5p, and miR-140-5p-in 50 female BC patients treated with paclitaxel (PTX) compared to 50 healthy controls...The findings underscore the importance of miRNAs in BC biology and their potential to guide personalized therapeutic strategies. Validation in larger cohorts is recommending and exploring miRNA-based interventions to improve patient outcomes and overcome chemoresistance in BC.
    Journal
    |
    MIR155 (MicroRNA 155) • MIR21 (MicroRNA 21) • MIR140 (MicroRNA 140) • MIR93 (MicroRNA 93)
    |
    paclitaxel