MIR136 (MicroRNA 136)

Furthermore, conducting robust validation in multicenter, larger-scale cohorts and establishing expanded cellular models that include gastric mucosal cells and subtype-representative cell lines will also be essential tasks. Despite these limitations, by identifying a targetable regulatory axis and providing directions for in-depth mechanistic and translational research on miR-136 as an early diagnostic and therapeutic target, this study still makes a meaningful contribution to research on H. pylori-associated GC.

In this editorial, we discuss the study by Chen et al. Although previous studies have identified roles for miR-136 in gastric cancer proliferation, apoptosis, and invasion, none have specifically explored its relationship with H. pylori-associated gastric carcinogenesis.

With the development of emerging technologies such as multi-omics technology, the pathways linking chronic inflammation to cancer have been extensively elucidated. In this letter, we focus on introducing the molecular mechanisms of chronic inflammation in the development of GC, which will provide new insights for early diagnosis, personalized treatment, and prognosis assessment of GC.

miRNA-136-5p can be proposed as a biomarker in cervical tumorigenesis, while miRNA-320a-3p can be used for treatment response and locoregional recurrence prediction.

miR-136 is a novel diagnostic biomarker and therapeutic target in H. pylori-associated early-stage gastric carcinogenesis and acts through the NF-κB-miR-136-PDCD11 pathway.

Experiment results indicated that only miR-136-3p was markedly reduced in both serum and tissue. In this study, we established the miRNA-mRNA network, offering potential PCa targets.

ceRNA network analysis predicted that hsa_circ_0000831 targets five miRNAs (including hsa-miR-136-5p, hsa-miR-100-3p, hsa-miR-144-5p, hsa-miR-149-5p and hsa-miR-214-5p), with the associated target genes mainly enriched in cancer-related pathways. This work offer s a novel foundation for the early identification of OSCC and provides potential clues for finding new therapeutic targets.

miR-136-5p is downregulated in glioma tissues and closely correlates with tumor CT signs. It may serve as a promising biomarker to assist in glioma diagnosis using CT scans.

These analyses suggest that these 3' UTR SNPs may have a functional impact on the STAT1 gene's regulation through their predicted effect on miRNA binding sites. Future experimental validation could establish their potential role in the diagnosis and treatment of various diseases, including cancer.

High circTMEM56 expression in HCC modulates the distant effects of HCC RT by activating the cGAS-STING pathway to reshape the tumor microenvironment. This study provides a new approach to improve RT efficacy for HCC.

MiR-136 demonstrates promising potential as a novel biomarker and therapeutic target in various human cancers. Further research is needed to fully elucidate its complex roles in cancer development, progression, and drug resistance, particularly regarding its potential in immunotherapy.