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    GENE:

    MIR133A1 (MicroRNA 133a-1)

    i
    Other names: MIR133A1, MicroRNA 133a-1, Hsa-Mir-133a-1, Hsa-MiR-133a-3p, Hsa-MiR-133a-5p, MIRN133A1, Hsa-Mir-133-P2-V1, Hsa-Mir-133-P2-V2, MIMAT0000427, MIMAT0026478, Mir-133a-1, MI0000450, RF00446
    Associations

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    Trials
    3ms
    Isoform-Specific Transcriptomic Effects of miR-133A1, miR-133A2, and miR-133B in a Colorectal Cancer Cell Line. (PubMed, Genes (Basel))
    These findings suggest that miR-133 isoforms exert both shared and subtly divergent regulatory functions in colorectal cancer, coordinating apoptosis, proliferation, migration, and signaling network modulation. Isoform-specific transcriptional regulation of miR-133 may contribute to tumor progression and represents a potential biomarker and therapeutic target in CRC.
    Preclinical • Journal
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    MIR133A1 (MicroRNA 133a-1) • MIR133B (MicroRNA 133b)
    over3years
    An Exosomal miRNA Biomarker for the Detection of Pancreatic Ductal Adenocarcinoma. (PubMed, Biosensors (Basel))
    Exosomal RNA from cell culture media was analyzed via RTqPCR and seven mature miRs exhibited statistical significance (miR-31-5p, miR-31-3p, miR-210-3p, miR-339-5p, miR-425-5p, miR-425-3p, and miR-429). These identified biomarkers can potentially be used for early detection of PDAC.
    Journal
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    MIR429 (MicroRNA 429) • MIR210 (MicroRNA 210) • MIR31 (MicroRNA 31) • MIR425 (MicroRNA 425) • MIR133A1 (MicroRNA 133a-1) • MIR29A (MicroRNA 29a) • MIR330 (MicroRNA 330) • MIR33A (MicroRNA 33a) • MIR93 (MicroRNA 93)
    over3years
    MIR133A regulates cell proliferation, migration, and apoptosis by targeting SOX9 in human colorectal cancer cells. (PubMed, Am J Cancer Res)
    We also used a xenograft model to show that MIR133A overexpression suppresses tumor growth and proliferation. Our results suggest that MIR133A regulates cell proliferation, migration, and apoptosis by targeting SOX9 in human colorectal cancer.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • MAP2K1 (Mitogen-activated protein kinase kinase 1) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MAPK1 (Mitogen-activated protein kinase 1) • SOX9 (SRY-Box Transcription Factor 9) • YBX1 (Y-Box Binding Protein 1) • MIR133A1 (MicroRNA 133a-1)