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    GENE:

    MIR1323 (MicroRNA 1323)

    i
    Other names: MIR1323, MicroRNA 1323, Hsa-Mir-1323, MIRN1323, MIMAT0005795, Hsa-MiR-1323, MI0003786, Mir-1323
    Associations

    News

    Trials
    3ms
    The Role of Chinese Medicines in Targeting Non-coding RNAs to Overcome Cancer Drug Resistance: Mechanisms and Clinical Translation Challenges. (PubMed, Pharmacol Res)
    Bridging this gap requires future research to prioritize in-depth mechanism studies, advanced delivery systems, and rigorous clinical validation related to ncRNA biomarkers. CHEMICAL COMPOUNDS IN THIS ARTICLE: Curcumin; Berberine; β-Elemene; Astragaloside IV; Icariin; Matrine; Toosendanin; Artesunate; Resveratrol; Cantharidin.
    Review • Journal
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    EGFR (Epidermal growth factor receptor) • MIR206 (MicroRNA 206) • MIR1323 (MicroRNA 1323)
    over1year
    Circ_0084653 promotes the tumor progression and immune escape in triple-negative breast cancer via the deubiquitination of MYC and upregulation of SOX5. (PubMed, Int J Biol Macromol)
    Meanwhile, transcription factor SOX5 activated transcriptionally circ_0084653. To sum up, SOX5-induced circ_0084653 promotes TNBC via the deubiquitination of USP36, which may provide some fresh ideas for TNBC-related molecular mechanisms.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • YBX1 (Y-Box Binding Protein 1) • MIR1323 (MicroRNA 1323)
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    PD-L1 expression
    2years
    MicroRNA profiling in complete and partial hydatidiform moles. (PubMed, Malays J Pathol)
    miR-518 was consistently observed to be downregulated in CM versus PM, and CM versus NMA. Further bioinformatic analysis to provide insight into the possible role of these miRNAs in the pathogenesis of HMs, progression of disease and as potential diagnostic biomarkers as well as therapeutic targets for HMs is needed.
    Journal
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    MIR503 (MicroRNA 503) • MIR1323 (MicroRNA 1323) • MIR423 (MicroRNA 423)
    over2years
    Identification of differentially expressed miRNAs and mRNAs associated with the regulation of breast cancer via in silico and in vitro methods. (PubMed, Cytotechnology)
    Notably, miR-1323-5p, miR-129-5p, and miR-628-5p are differentially expressed in BC and they bind to 3'UTR of critical genes of Lysine degradation pathway, namely SETD7, SETDB2 and EHHADH. These miRNAs might serve as potential diagnostic and prognostic biomarkers for progression.
    Preclinical • Journal
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    KMT2A (Lysine Methyltransferase 2A) • MIR129 (MicroRNA 129) • MIR1323 (MicroRNA 1323) • MIR628 (MicroRNA 628) • SETD7 (SET Domain Containing 7)
    over2years
    NPHS2-6 drives cervical squamous cell carcinoma (CSCC) progression via hsa-miR-1323/SMC1B axis to activate PI3K-Akt pathway. (PubMed, Clin Transl Oncol)
    In conclusion, NPHS2-6/miR-1323/SMC1B/PI3K/Akt signaling accelerates the progression of CSCC, providing a new direction for the treatment strategy of CSCC.
    Journal
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    MIR1323 (MicroRNA 1323)
    almost4years
    Exosome-Mediated Transfer of miR-1323 from Cancer-Associated Fibroblasts Confers Radioresistance of C33A Cells by Targeting PABPN1 and Activating Wnt/β-Catenin Signaling Pathway in Cervical Cancer. (PubMed, Reprod Sci)
    Therefore, rescue experiments were implemented to validate that PABPN1 overexpression rescued the inhibited cancer development and radioresistance induced by the miR-1323 inhibitor. In conclusion, miR-1323 was involved in CCa progression and radioresistance which might provide a novel insight for CCa treatment.
    Journal
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    IGF2 (Insulin-like growth factor 2) • IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • MIR1323 (MicroRNA 1323)