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MIR130A (MicroRNA 130a)

News alerts, weekly reports and conference planners

11d

Gastric Cancer Epithelial-Mesenchymal Transition-The Role of Micro-RNA. (PubMed, Cancers (Basel))

Several EMT-related miRNAs show consistent associations with invasion, metastasis, peritoneal dissemination, prognosis, and chemoresistance, and many are detectable in circulation. Overall, EMT-related miRNAs orchestrate gastric cancer cell plasticity and tumor-microenvironment crosstalk and represent promising biomarker and therapeutic candidates that warrant validation in prospective, subtype-stratified, and translational studies.

11 days ago

Review • Journal

MET (MET proto-oncogene, receptor tyrosine kinase) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR21 (MicroRNA 21) • MIR34A (MicroRNA 34a-5p) • TGFB1 (Transforming Growth Factor Beta 1) • MIR192 (MicroRNA 192) • MIR27A (MicroRNA 27a) • MIR17 (MicroRNA 17) • MIR23A (MicroRNA 23a) • MIR375 (MicroRNA 375) • MIR506 (MicroRNA 506) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • MIR106B (MicroRNA 106b) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR150 (MicroRNA 150) • MIR181A1 (MicroRNA 181a-1) • MIR200 (MicroRNA 200) • MIR204 (MicroRNA 204) • MIR218 (MicroRNA 218) • MIR26A1 (MicroRNA 26a-1) • MIR30A (MicroRNA 30a)

26d

RETRACTION: Long Non-Coding RNA FEZF1-AS1 Induced Progression of Ovarian Cancer via Regulating miR-130a-5p/SOX4 Axis. (PubMed, J Cell Mol Med)

The retraction has been agreed to because the evidence of image re-use and manipulation with multiple previously published articles fundamentally compromises the editors' confidence in the results presented. The authors did not respond to our notice regarding the retraction.

26 days ago

Journal

GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • MIR130A (MicroRNA 130a)

Elemene Augments the Effects of Anti-PD-1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR-130a-5p/SPP/MHC-I Axis. (PubMed, Adv Sci (Weinh))

Moreover, the functional significance of the miR-130a-5p/SPP/MHC-I axis in modulating the tumor immune microenvironment is systematically validated through in vitro and in vivo HCC models, as well as in clinical patient specimens. These findings underscore the potential of combining elemene with anti-PD-1 therapy as a safe and effective treatment strategy for HCC, offering significant translational promise for improving patient outcomes.

1 month ago

Journal

MIR130A (MicroRNA 130a)

2ms

TNFα protein, DNA methylation, mRNA and miRNA expression evaluation in multiple sclerosis. (PubMed, Front Mol Biosci)

The data indicate that TNFα upregulation in RRMS is associated with promoter hypomethylation and reduced miR-130a-3p expression, suggesting a coordinated epigenetic and post-transcriptional control of this cytokine. The parallel trends observed in saliva and serum highlight the potential use of salivary TNFα and miR-130a-3p as minimally invasive biomarkers for MS monitoring and early diagnosis.

2 months ago

Journal

TNFA (Tumor Necrosis Factor-Alpha) • MIR130A (MicroRNA 130a)

2ms

Role of EpCAM-Positive Exosomes in Ovarian Cancer: MiRNA Signatures of Chemoresistance and Disease Progression. (PubMed, Asia Pac J Clin Oncol)

Overall, the study highlights a probable mechanism for miRNA packaging and release in OC through EpCAM-positive exosomes, offering potential biomarkers for monitoring disease progression and relapse.

2 months ago

Journal

EPCAM (Epithelial cell adhesion molecule) • MIR182 (MicroRNA 182) • MIR23b (MicroRNA 23b) • MIR130A (MicroRNA 130a) • MIR20A (MicroRNA 20a)

2ms

Identification and experimental validation of biomarkers associated with paraptosis in meningioma. (PubMed, Medicine (Baltimore))

ITPR3, MAPK1, and MAPK8 are biomarkers for meningioma, all targeted by SMAD3. Tamoxifen could treat meningioma by affecting paraptosis pathways, offering a promising basis for targeted therapy development.

2 months ago

Journal

MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • MAPK1 (Mitogen-activated protein kinase 1) • MIR17HG (MiR-17-92a-1 Cluster Host Gene) • MIR506 (MicroRNA 506) • MIR92A1 (MicroRNA 92a-1) • MAPK8 (Mitogen-activated protein kinase 8) • MIR130A (MicroRNA 130a) • NORAD (Non-Coding RNA Activated By DNA Damage) • SMAD3 (SMAD Family Member 3)

tamoxifen

3ms

Identification of anoikis-related genes and immune infiltration characteristics in Sjögren's syndrome based on machine learning. (PubMed, Front Med (Lausanne))

These genes likely mediate their effects by influencing immune cell infiltration, participating in immune regulation, and modulating inflammatory responses. Our findings offer new insights into drug selection and immunotherapeutic strategies for SS.

3 months ago

Journal • IO biomarker

CXCL10 (Chemokine (C-X-C motif) ligand 10) • BIRC3 (Baculoviral IAP repeat containing 3) • S100A9 (S100 Calcium Binding Protein A9) • MIR30B (MicroRNA 30b) • IFI27 (Interferon Alpha Inducible Protein 27) • IL15 (Interleukin 15) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MAPK3 (Mitogen-Activated Protein Kinase 3) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR483 (MicroRNA 483) • MIR486-1 (MicroRNA 486-1)

4ms

NEAT1 inhibits granulosa cell apoptosis and promotes cell growth and migration through the miR-130a-3p/BMP6 axis. (PubMed, Reprod Biomed Online)

NEAT1 inhibits apoptosis and promotes proliferation and migration of OGC through the miR-130a-3p/BMP6 axis, which may improve oocyte quality in patients with DOR. As such, NEAT1 may be a potential prognostic biomarker and therapeutic target for DOR.

4 months ago

Journal

NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • BMP6 (Bone Morphogenetic Protein 6) • MIR130A (MicroRNA 130a)

4ms

The microRNAs landscape of luminal B breast cancer cells in a three-dimensional microenvironment. (PubMed, Hereditas)

Overall, this study highlights the utility of 3D cultures in investigating the biology of breast cancer, emphasizing the critical interplay between lncRNAs, miRNAs, and mRNAs. Our findings provide insights into the discovery of novel potential biomarkers, underscoring the importance of integrating both in vitro 3D culture and in vivo expression data for a more accurate identification of miRNAs with possible applications in cancer therapies.

4 months ago

Journal

ER (Estrogen receptor) • TGFB1 (Transforming Growth Factor Beta 1) • MIR18A (MicroRNA 18a) • MIR130A (MicroRNA 130a)

4ms

The developed immune-related miRNA prognostic signature provided an accurate prediction of NPC prognosis. Additionally, the accompanying nomogram offered a practical tool for estimating patient OS, potentially aiding clinical decision-making.

4 months ago

Journal

MIR320A (MicroRNA 320a) • MIR130A (MicroRNA 130a) • MIR150 (MicroRNA 150) • MIR320B (MicroRNA 320b) • MIR342 (MicroRNA 342)

5ms

Diagnostic and prognostic potential of microRNA profiles in endometrioid endometrial cancer. (PubMed, Sci Rep)

We showed that miRNAs have good diagnostic sensitivity for identifying EEC and EC grading. In addition, miRNA improved the ability to discriminate between ECs of different grades.

5 months ago

Journal

KRAS (KRAS proto-oncogene GTPase) • PTEN (Phosphatase and tensin homolog) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR200B (MicroRNA 200b) • MIR21 (MicroRNA 21) • MIR200C (MicroRNA 200c) • MIR429 (MicroRNA 429) • MIR30B (MicroRNA 30b) • MIR324 (MicroRNA 324) • MIR543 (MicroRNA 543) • MIR96 (MicroRNA 96) • Let-7c (MicroRNA Let-7c) • MIR126 (MicroRNA 126) • MIR141 (MicroRNA 141) • MIR182 (MicroRNA 182) • MIR18A (MicroRNA 18a) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2) • MIR130A (MicroRNA 130a) • MIR181B1 (MicroRNA 181b-1) • MIR183 (MicroRNA 183) • MIR203A (MicroRNA 203a) • MIR205 (MicroRNA 205) • MIR217 (MicroRNA 217) • MIR30C • MIRLET7E (MicroRNA Let-7e)