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    GENE:

    MIR129 (MicroRNA 129)

    i
    Other names: MIR129, MicroRNA 129
    Associations

    News

    Trials
    9d
    The Dual Role of DNA Methylation Test Can Optimize the Clinical Application of High-Risk Human Papillomavirus Testing in Detecting Cervical Intraepithelial Neoplasia Grade 3 or Worse. (PubMed, J Med Virol)
    This study substantiates the dual role of DNA methylation detection in cervical cancer screening. By incorporating methylation detection, the existing HPV-based screening strategy can be further optimized to achieve precise risk stratification and facilitate the shift from cervical cancer screening to personalized and precise management.
    Journal
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    MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)
    1m
    Rutin alleviates pirarubicin-induced cardiotoxicity and enhances chemosensitivity in breast cancer. (PubMed, Phytomedicine)
    Rutin mitigates THP-induced cardiotoxicity and enhances chemotherapeutic efficacy via the novel miR-129-1-3p/GRIN2D pathway. Our data show miR-129-1-3p to be an essential mediator, and suggest that the rutin-miR-129-1-3p-GRIN2D axis is a favorable target for improving the safety and effectiveness of breast cancer chemotherapy.
    Journal
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    MIR129 (MicroRNA 129) • MIR129-1 (MicroRNA 129-1) • GRIN2D (Glutamate Ionotropic Receptor NMDA Type Subunit 2D)
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    Pinorubin (pirarubicin)
    2ms
    Coordinated Expression and Methylation of microRNAs: Role in Common Biological Processes and Signaling Pathways in Breast Cancer (PubMed, Mol Biol (Mosk))
    Indeed, for the pairs miR-127-5p/miR-125b-5p, miR-148a-3p/miR-125b-5p, miR-148a-3p/miR-132-3p, and miR-34b-3p/miR-193a-5p, common mRNA targets and involvement in biological processes, including pathways associated with epigenetic regulation, proliferation, and metastasis, were revealed. The miRNA-mRNA regulatory network constructed involving DNMTs and EZH2 highlights their potential role in breast cancer progression and demonstrates diagnostic and prognostic significance.
    Journal
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    MIR132 (MicroRNA 132) • MIR127 (MicroRNA 127) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2) • MIR148A (MicroRNA 148a) • MIR193A (MicroRNA 193a) • MIR34B (MicroRNA 34b)
    3ms
    Multi-omics profiling identifies ESM1 as a key mediator of immunoevasion through the SPP1 pathway in bladder cancer. (PubMed, Sci Rep)
    Overexpressed ESM1 may mediate a reduced level of immune cell infiltration in TME through immune signalling pathways. ESM1 can be used as a predictive biomarker for immune-related and clinical progression in BC.
    Journal • IO biomarker
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    SPP1 (Secreted Phosphoprotein 1) • TERC (Telomerase RNA Component) • MIR129 (MicroRNA 129) • ESM1 (Endothelial Cell Specific Molecule 1)
    3ms
    LINC01614 promoted malignant progression of stomach adenocarcinoma via miR-129-2-3p. (PubMed, Cytotechnology)
    LINC01614 may represent a novel molecular target for STAD. The online version contains supplementary material available at 10.1007/s10616-025-00870-z.
    Journal
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    MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)
    4ms
    miR-129 as a Molecular Biomarker in Gastric Cancer and Its Association with Neurodegenerative and Vascular Pathology. (PubMed, Life (Basel))
    Gastric juice-derived miR-129 is downregulated in gastric adenocarcinoma, with progressive decline across tumor stages. Its inverse association with systemic tumor and inflammatory markers, as well as vascular and neurological impairment, suggests that miR-129 may function as a minimally invasive, multi-system biomarker for integrated cancer and vascular-neurological risk assessment.
    Journal
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    MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)
    4ms
    lncRNA LINC00958 Activates NOTCH3 by Competitively Inhibiting miR-129-2-3p to Exacerbate the Malignant Biological Behaviors of Endometrial Cancer Cells. (PubMed, Kaohsiung J Med Sci)
    Overall, this study identifies LINC00958 as a novel oncogenic lncRNA in EC, which facilitates tumor progression by sponging miR-129-2-3p and enhancing NOTCH3 signaling. These findings provide new insights into the molecular mechanisms of EC and suggest that targeting the LINC00958/miR-129-2-3p/NOTCH3 axis may represent a promising therapeutic strategy.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • NOTCH3 (Notch Receptor 3) • CASP3 (Caspase 3) • LINC00958 (Long Intergenic Non-Protein Coding RNA 958) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)
    5ms
    Experimental Study on the Inhibitory Effect of Eupatilin on Osteosarcoma by the NBR2/miR-129-5p/FKBP11 Regulatory Axis. (PubMed, Ann Surg Oncol)
    Eupatilin exerts a reliable inhibitory effect on osteosarcoma cells through the NBR2/miR-129-5p/FKBP11 regulatory axis. Exosomes can effectively carry both eupatilin and miR-129-5p, enhancing their therapeutic efficacy.
    Journal • BRCA Biomarker
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    BRCA1 (Breast cancer 1, early onset) • MIR129 (MicroRNA 129) • NBR2 (Neighbor Of BRCA1 LncRNA)
    5ms
    Diagnostic and prognostic potential of microRNA profiles in endometrioid endometrial cancer. (PubMed, Sci Rep)
    We showed that miRNAs have good diagnostic sensitivity for identifying EEC and EC grading. In addition, miRNA improved the ability to discriminate between ECs of different grades.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • PTEN (Phosphatase and tensin homolog) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR200B (MicroRNA 200b) • MIR21 (MicroRNA 21) • MIR200C (MicroRNA 200c) • MIR429 (MicroRNA 429) • MIR30B (MicroRNA 30b) • MIR324 (MicroRNA 324) • MIR543 (MicroRNA 543) • MIR96 (MicroRNA 96) • Let-7c (MicroRNA Let-7c) • MIR126 (MicroRNA 126) • MIR141 (MicroRNA 141) • MIR182 (MicroRNA 182) • MIR18A (MicroRNA 18a) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2) • MIR130A (MicroRNA 130a) • MIR181B1 (MicroRNA 181b-1) • MIR183 (MicroRNA 183) • MIR203A (MicroRNA 203a) • MIR205 (MicroRNA 205) • MIR217 (MicroRNA 217) • MIR30C • MIRLET7E (MicroRNA Let-7e)
    5ms
    miR-129-5p regulates HMGB1/RAGE axis to inhibit pyroptosis and ameliorate cervical epithelial cell deterioration. (PubMed, Eur J Histochem)
    Cells overexpressing miR-129-5p exhibited attenuated caspase-1 activity with enhanced survival and proliferation following LPS treatment. Collectively, these in vitro findings indicate that miR-129-5p suppresses HMGB1/RAGE-mediated pyroptosis and cellular deterioration and also provide new mechanistic insights for cervical cancer therapeutics.
    Journal
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    HMGB1 (High Mobility Group Box 1) • MIR129 (MicroRNA 129)
    5ms
    Supervising the recurrence of pancreatic ductal adenocarcinoma using CtDNA-based MIR129-2 methylation detection. (PubMed, Int J Surg)
    Postoperative measurement of ctDNA-based MIR129-2 methylation can be used to predict PDAC recurrence risk, offering a cost-effective assay to facilitate the postoperative management of PDAC patients.
    Journal • Circulating tumor DNA
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    CA 19-9 (Cancer antigen 19-9) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)