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    GENE:

    MIR129-2 (MicroRNA 129-2)

    i
    Other names: MicroRNA 129-2, Hsa-MiR-129-2-3p, Hsa-MiR-129-5p, Hsa-Mir-129-2, Hsa-Mir-129-P2, MIRN129-2, Mir-129-2, MIR-129b, MIR129-2
    Associations

    News

    Trials
    9d
    The Dual Role of DNA Methylation Test Can Optimize the Clinical Application of High-Risk Human Papillomavirus Testing in Detecting Cervical Intraepithelial Neoplasia Grade 3 or Worse. (PubMed, J Med Virol)
    This study substantiates the dual role of DNA methylation detection in cervical cancer screening. By incorporating methylation detection, the existing HPV-based screening strategy can be further optimized to achieve precise risk stratification and facilitate the shift from cervical cancer screening to personalized and precise management.
    Journal
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    MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)
    2ms
    Coordinated Expression and Methylation of microRNAs: Role in Common Biological Processes and Signaling Pathways in Breast Cancer (PubMed, Mol Biol (Mosk))
    Indeed, for the pairs miR-127-5p/miR-125b-5p, miR-148a-3p/miR-125b-5p, miR-148a-3p/miR-132-3p, and miR-34b-3p/miR-193a-5p, common mRNA targets and involvement in biological processes, including pathways associated with epigenetic regulation, proliferation, and metastasis, were revealed. The miRNA-mRNA regulatory network constructed involving DNMTs and EZH2 highlights their potential role in breast cancer progression and demonstrates diagnostic and prognostic significance.
    Journal
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    MIR132 (MicroRNA 132) • MIR127 (MicroRNA 127) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2) • MIR148A (MicroRNA 148a) • MIR193A (MicroRNA 193a) • MIR34B (MicroRNA 34b)
    3ms
    LINC01614 promoted malignant progression of stomach adenocarcinoma via miR-129-2-3p. (PubMed, Cytotechnology)
    LINC01614 may represent a novel molecular target for STAD. The online version contains supplementary material available at 10.1007/s10616-025-00870-z.
    Journal
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    MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)
    4ms
    miR-129 as a Molecular Biomarker in Gastric Cancer and Its Association with Neurodegenerative and Vascular Pathology. (PubMed, Life (Basel))
    Gastric juice-derived miR-129 is downregulated in gastric adenocarcinoma, with progressive decline across tumor stages. Its inverse association with systemic tumor and inflammatory markers, as well as vascular and neurological impairment, suggests that miR-129 may function as a minimally invasive, multi-system biomarker for integrated cancer and vascular-neurological risk assessment.
    Journal
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    MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)
    4ms
    lncRNA LINC00958 Activates NOTCH3 by Competitively Inhibiting miR-129-2-3p to Exacerbate the Malignant Biological Behaviors of Endometrial Cancer Cells. (PubMed, Kaohsiung J Med Sci)
    Overall, this study identifies LINC00958 as a novel oncogenic lncRNA in EC, which facilitates tumor progression by sponging miR-129-2-3p and enhancing NOTCH3 signaling. These findings provide new insights into the molecular mechanisms of EC and suggest that targeting the LINC00958/miR-129-2-3p/NOTCH3 axis may represent a promising therapeutic strategy.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • NOTCH3 (Notch Receptor 3) • CASP3 (Caspase 3) • LINC00958 (Long Intergenic Non-Protein Coding RNA 958) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)
    5ms
    Diagnostic and prognostic potential of microRNA profiles in endometrioid endometrial cancer. (PubMed, Sci Rep)
    We showed that miRNAs have good diagnostic sensitivity for identifying EEC and EC grading. In addition, miRNA improved the ability to discriminate between ECs of different grades.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • PTEN (Phosphatase and tensin homolog) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR200B (MicroRNA 200b) • MIR21 (MicroRNA 21) • MIR200C (MicroRNA 200c) • MIR429 (MicroRNA 429) • MIR30B (MicroRNA 30b) • MIR324 (MicroRNA 324) • MIR543 (MicroRNA 543) • MIR96 (MicroRNA 96) • Let-7c (MicroRNA Let-7c) • MIR126 (MicroRNA 126) • MIR141 (MicroRNA 141) • MIR182 (MicroRNA 182) • MIR18A (MicroRNA 18a) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2) • MIR130A (MicroRNA 130a) • MIR181B1 (MicroRNA 181b-1) • MIR183 (MicroRNA 183) • MIR203A (MicroRNA 203a) • MIR205 (MicroRNA 205) • MIR217 (MicroRNA 217) • MIR30C • MIRLET7E (MicroRNA Let-7e)
    5ms
    Supervising the recurrence of pancreatic ductal adenocarcinoma using CtDNA-based MIR129-2 methylation detection. (PubMed, Int J Surg)
    Postoperative measurement of ctDNA-based MIR129-2 methylation can be used to predict PDAC recurrence risk, offering a cost-effective assay to facilitate the postoperative management of PDAC patients.
    Journal • Circulating tumor DNA
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    CA 19-9 (Cancer antigen 19-9) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)
    10ms
    Multi-cancer early detection via a DNA methylation multiplex ddPCR-based blood test. (PubMed, Int J Cancer)
    Additionally, the test detected nine other cancer types in plasma. This proof-of-concept study demonstrates the feasibility of a single methylation-targeted blood test for multi-cancer detection, offering potential as an affordable and scalable screening tool for early cancer detection.
    Journal
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    MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)
    10ms
    DNA Methylation Biomarker Discovery for Colorectal Cancer Diagnosis Assistance Through Integrated Analysis. (PubMed, Cancer Inform)
    Using integrated DNA methylation analysis, we identified 3 CRC-related biomarkers with remarkable classification performance. These biomarkers can be used to design a practical clinical toolkit for CRC diagnosis assistance and may also serve as candidate biomarkers for further clinical experiments through liquid biopsies.
    Journal
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    ADHFE1 (Alcohol Dehydrogenase Iron Containing 1) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)
    11ms
    Discovery and Validation of Immune Infiltration-related Genes for the Prognosis of Osteoporosis. (PubMed, Iran J Allergy Asthma Immunol)
    Our findings suggest that these immune-related genes may predict OP prognosis and offer new perspectives for early prevention and intervention strategies. The identification of specific immune genes involved in OP development highlights their potential as therapeutic targets for further investigation.
    Journal
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    CXCL10 (Chemokine (C-X-C motif) ligand 10) • HMOX1 (Heme Oxygenase 1) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)
    11ms
    Hypermethylation of miR-129-2-3p inhibits esophageal cancer proliferation and migration by down-regulating PPP6C expression. (PubMed, Am J Transl Res)
    Hypermethylated miR-129-2-3p inhibits EC cell proliferation and migration by downregulating PPP6C expression, suggesting that miR-129-2-3p may serve as a potential diagnostic biomarker for EC.
    Journal
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    MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2)