MIR127 (MicroRNA 127)

Molecular docking analyses demonstrated favorable binding of active compounds like formononetin and cinnamic acid to TBX5. Our findings suggested a potential association between GQD, TBX5-related genes, and CRC progression, which could provide valuable insights for the diagnosis and treatment of CRC.

CircCCDC66 is upregulated in ccRCC and promotes tumorigenesis and progression by acting as a miR-1278 sponge to derepress HOXA13 expression.

Our findings indicate that sex disparities in bladder cancer are largely driven by post-transcriptional regulation of autosomal genes, rather than sex chromosome dosage. By linking sex-biased microRNAs, target genes, and patient survival with cell type-specific expression, this study provides new insight into the biological basis of sex differences in bladder cancer. These results underscore the importance of incorporating sex as a critical variable in biomarker development, therapeutic targeting, and clinical trial design.

This MR study establishes plasma miRNAs as causal mediators of gastric carcinogenesis, with miR-409-3p emerging as a key prognostic biomarker. The identified miRNA-target networks highlight actionable pathways for therapeutic intervention, bridging genetic epidemiology with functional genomics in GC precision oncology.

Indeed, for the pairs miR-127-5p/miR-125b-5p, miR-148a-3p/miR-125b-5p, miR-148a-3p/miR-132-3p, and miR-34b-3p/miR-193a-5p, common mRNA targets and involvement in biological processes, including pathways associated with epigenetic regulation, proliferation, and metastasis, were revealed. The miRNA-mRNA regulatory network constructed involving DNMTs and EZH2 highlights their potential role in breast cancer progression and demonstrates diagnostic and prognostic significance.

Collectively, our findings highlight circRNF10 as a tumor suppressor in driver gene-negative LUAD and suggest that restoring circRNF10 expression represents a promising therapeutic approach for this refractory subtype.

UBE2V1 was identified as a key miR-1275 target involved in cancer-related pathways, including ubiquitination and mTOR signaling.ConclusionSerum exosomal miR-1275 is a promising biomarker for early diagnosis and prognosis of HCC. Its integration into multimarker panels could enhance clinical decision-making and patient management.

This study is the first to demonstrate that hsa_circ_0007439 functions as a competitive endogenous RNA to upregulate KRT1 expression, thereby promoting the metastasis of NPC, suggesting that hsa_circ_0007439 serve as a potential diagnostic biomarker and therapeutic target for NPC.

miR-127-3p inhibited the growth of transplanted tumors in TNBC nude mice. Overall, miR-127-3p targets KIF3B, thereby reducing TNBC cell stemness and reversing DTX resistance.

These molecular signatures support the idea that mitochondrial dysfunction in ASD is tied to specific disruptions in the mTOR and PI3K/AKT signaling axes, influencing cell growth, autophagy, oxidative stress handling, and neuronal metabolism. The findings highlight a miRNA-mRNA regulatory network that may underpin mitochondrial dysfunction and ASD heterogeneity, suggesting avenues for subtype-specific biomarkers and targeted therapies that address energy metabolism and cellular stress in ASD.

Serum miR-197-3p and miR-1236 hold promise as complementary biomarkers for early BC detection. Larger multicenter studies are warranted to validate their clinical utility.

Notably, combining circFOXK2 overexpression with bevacizumab produced a synergistic effect, suggesting a potential therapeutic strategy. Our findings emphasize the critical role of the circFOXK2/miR-1275/CLDN1 axis in regulating vascular permeability and angiogenesis in advanced LUAD, positioning this axis as a promising therapeutic target.