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    GENE:

    MIR124-3 (MicroRNA 124-3)

    i
    Other names: MIR124-3, MicroRNA 124-3, Hsa-Mir-124a-3, Hsa-MiR-124-3p, Hsa-MiR-124-5p, Hsa-Mir-124-3, MicroRNA 124a-3, MIRN124-3, MIRN124A3, Hsa-Mir-124-P3-V2_pre, Hsa-Mir-124-P3-V1_pre, MIMAT0000422, MIMAT0004591, Mir-124-3, MI0000445, RF00239
    Associations

    News

    Trials
    5d
    MiR-124-3p Suppresses Glioma Cells Progression by Targeting STAT3/NAMPT and Inhibiting AKT/ERK Signaling. (PubMed, Curr Cancer Drug Targets)
    MiR-124-3p functions as a tumor suppressor in glioma by repressing STAT3/NAMPT-mediated AKT/ERK signaling, highlighting its potential as a diagnostic biomarker and therapeutic target for glioma management.
    Journal
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    STAT3 (Signal Transducer And Activator Of Transcription 3) • NAMPT (Nicotinamide Phosphoribosyltransferase) • MIR124-3 (MicroRNA 124-3)
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    IDH wild-type
    16d
    MicroRNA combinations function as synergistic network regulators of neuroblastoma differentiation. (PubMed, bioRxiv)
    Together, these findings establish miRNA combinations as programmable network regulators capable of inducing complex cellular phenotypes with greater efficacy than single agents. This work provides a conceptual and experimental framework for the rational discovery of synergistic miRNA therapeutics and suggests new avenues for differentiation-based treatment strategies in neuroblastoma and other diseases driven by dysregulated regulatory networks.
    Journal
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    MIR363 (MicroRNA 363) • MIR124-3 (MicroRNA 124-3)
    2ms
    bayesReact: expression-coupled regulatory motif analysis detects microRNA activity across cancers, tissues, and at the single-cell level. (PubMed, Nucleic Acids Res)
    bayesReact enables large-scale hypothesis-generating screens for novel regulatory factors and the discovery of condition-specific activities. It is implemented as a user-friendly R package (https://github.com/JakobSkouPedersenLab/bayesReact).
    Journal
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    MIR122 (MicroRNA 122) • SFMBT2 (Scm Like With Four Mbt Domains 2) • MIR124-3 (MicroRNA 124-3)
    3ms
    The Role of microRNAs as Potential Biomarkers in Diffuse Large B-Cell Lymphoma. (PubMed, Noncoding RNA)
    While novel therapies such as rituximab and polatuzumab vedotin have led to improved outcomes, approximately 35% of patients eventually develop relapsed or refractory disease. Among these, miR-155 and miR-21 are particularly well studied, playing central roles in both tumor progression and remodeling of the tumor microenvironment. This review summarizes current evidence on the biological and clinical relevance of miRNAs in DLBCL, emphasizing their diagnostic and prognostic potential.
    Review • Journal
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    MIR155 (MicroRNA 155) • MIR21 (MicroRNA 21) • MIR17HG (MiR-17-92a-1 Cluster Host Gene) • MIR34A (MicroRNA 34a-5p) • MIR17 (MicroRNA 17) • MIR181A1 (MicroRNA 181a-1) • MIR124-3 (MicroRNA 124-3)
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    Rituxan (rituximab) • Polivy (polatuzumab vedotin-piiq)
    3ms
    Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)
    The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.
    Journal
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    TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)
    3ms
    MiR-124-3p inhibits stomach adenocarcinoma progression by targeting AHR to induce autophagy. (PubMed, Cell Div)
    These findings establish miR-124-3p as a key suppressor of STAD progression via AHR-mediated autophagy, underscoring its promise as both a diagnostic biomarker and a therapeutic candidate.
    Journal
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    AHR (Aryl hydrocarbon receptor) • MIR124-3 (MicroRNA 124-3)
    3ms
    MicroRNA Signatures and Machine Learning Models for Predicting Cardiotoxicity in HER2-Positive Breast Cancer Patients. (PubMed, Pharmaceuticals (Basel))
    Background: HER2-positive breast cancer patients receiving chemotherapy and targeted therapy (including anthracyclines and trastuzumab) face an elevated risk of cardiotoxicity, which can lead to long-term cardiovascular complications... Circulating miRNAs show promise as biomarkers for predicting cardiotoxicity in breast cancer patients. Machine learning approaches may enhance miRNA-based risk stratification, enabling personalized monitoring and early cardioprotective interventions.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • MIR155 (MicroRNA 155) • MIR199A1 (MicroRNA 199a-1) • MIR143 (MicroRNA 143) • MIR17 (MicroRNA 17) • MIR199A (MicroRNA 199a) • miR-185 (MicroRNA 185) • MIR124-2 (MicroRNA 124-2) • MIR133B (MicroRNA 133b) • MIR145 (MicroRNA 145) • MIR124-3 (MicroRNA 124-3)
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    HER-2 positive
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    Herceptin (trastuzumab)
    4ms
    Heterogeneity study on MiRNA expression in islet cells of rat pancreatic head and tail. (PubMed, BMC Med Genomics)
    Our findings provide novel insights into the heterogeneity of miRNA expression in the pancreas and the molecular mechanisms underlying pancreatic cancer, offering potential targets for future diagnostic and therapeutic strategies.
    Preclinical • Journal
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    MIR124-3 (MicroRNA 124-3)
    4ms
    MicroRNA-124-3p suppresses lung cancer by targeting ITGB1/PI3K/p-AKT signal transduction pathway. (PubMed, Exp Cell Res)
    Consistent with this, bioinformatics analysis demonstrated that miR-124-3p expression is significantly lower in tumor tissues than in adjacent normal lung and further decreases in advanced T stage (T3-T4) compared to early stage (T1-T2). These findings indicate that miR-124-3p inhibits NSCLC progression via the ITGB1/PI3K/p-AKT axis and remains functional despite PIK3CA activation, supporting its potential as a therapeutic candidate.
    Journal
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    PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • ITGB1 (Integrin Subunit Beta 1) • MIR124-3 (MicroRNA 124-3)
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    PIK3CA mutation
    5ms
    Aberrant MicroRNA-124 expression and methylation in the dorsolateral prefrontal cortex of depressed subjects. (PubMed, J Psychiatr Res)
    Furthermore, we identified a significant reduction in DNA methylation in one of the miR-124 promoter regions on chromosome 20 in MDD subjects. Our results provide new insights into the epigenetic regulation of miR-124-3p in the brains of MDD subjects and highlight its potential role in MDD pathophysiology.
    Journal
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    MIR124-3 (MicroRNA 124-3)
    5ms
    Identification and validation of stage-specific microRNAs and target genes for prostate cancer: Utilizing bioinformatics tools for diagnostic marker discovery. (PubMed, PLoS One)
    We also identified the tumor suppressor role of miR-17-5p, which was associated with higher Gleason scores. We propose PRC1, UBA52, RCC1, miR-124-3p and miR133a-3p as stage-specific PCa identifiers.
    Journal
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    MIR17 (MicroRNA 17) • MIR33A (MicroRNA 33a) • MIR124-3 (MicroRNA 124-3)
    5ms
    miR-124 Targets EGFR and Attenuates Growth and Invasion in Bladder Cancer Cells. (PubMed, In Vivo)
    miR-124-3p suppresses bladder cancer cells progression by directly targeting and inactivating EGFR, thereby impairing cell proliferation, migration, and invasion. These findings highlight miR-124-3p as a potential therapeutic agent in EGFR-driven bladder cancer.
    Journal
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    EGFR (Epidermal growth factor receptor) • MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9) • MIR124-3 (MicroRNA 124-3)
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    erlotinib