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MIR124-3 (MicroRNA 124-3)

News alerts, weekly reports and conference planners

15d

bayesReact: expression-coupled regulatory motif analysis detects microRNA activity across cancers, tissues, and at the single-cell level. (PubMed, Nucleic Acids Res)

bayesReact enables large-scale hypothesis-generating screens for novel regulatory factors and the discovery of condition-specific activities. It is implemented as a user-friendly R package (https://github.com/JakobSkouPedersenLab/bayesReact).

15 days ago

Journal

MIR122 (MicroRNA 122) • SFMBT2 (Scm Like With Four Mbt Domains 2) • MIR124-3 (MicroRNA 124-3)

The Role of microRNAs as Potential Biomarkers in Diffuse Large B-Cell Lymphoma. (PubMed, Noncoding RNA)

While novel therapies such as rituximab and polatuzumab vedotin have led to improved outcomes, approximately 35% of patients eventually develop relapsed or refractory disease. Among these, miR-155 and miR-21 are particularly well studied, playing central roles in both tumor progression and remodeling of the tumor microenvironment. This review summarizes current evidence on the biological and clinical relevance of miRNAs in DLBCL, emphasizing their diagnostic and prognostic potential.

1 month ago

Review • Journal

MIR155 (MicroRNA 155) • MIR21 (MicroRNA 21) • MIR17HG (MiR-17-92a-1 Cluster Host Gene) • MIR34A (MicroRNA 34a-5p) • MIR17 (MicroRNA 17) • MIR181A1 (MicroRNA 181a-1) • MIR124-3 (MicroRNA 124-3)

Rituxan (rituximab) • Polivy (polatuzumab vedotin-piiq)

2ms

Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)

The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.

2 months ago

Journal

TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)

2ms

MiR-124-3p inhibits stomach adenocarcinoma progression by targeting AHR to induce autophagy. (PubMed, Cell Div)

These findings establish miR-124-3p as a key suppressor of STAD progression via AHR-mediated autophagy, underscoring its promise as both a diagnostic biomarker and a therapeutic candidate.

2 months ago

Journal

AHR (Aryl hydrocarbon receptor) • MIR124-3 (MicroRNA 124-3)

2ms

MicroRNA Signatures and Machine Learning Models for Predicting Cardiotoxicity in HER2-Positive Breast Cancer Patients. (PubMed, Pharmaceuticals (Basel))

Background: HER2-positive breast cancer patients receiving chemotherapy and targeted therapy (including anthracyclines and trastuzumab) face an elevated risk of cardiotoxicity, which can lead to long-term cardiovascular complications... Circulating miRNAs show promise as biomarkers for predicting cardiotoxicity in breast cancer patients. Machine learning approaches may enhance miRNA-based risk stratification, enabling personalized monitoring and early cardioprotective interventions.

2 months ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • MIR155 (MicroRNA 155) • MIR199A1 (MicroRNA 199a-1) • MIR143 (MicroRNA 143) • MIR17 (MicroRNA 17) • MIR199A (MicroRNA 199a) • miR-185 (MicroRNA 185) • MIR124-2 (MicroRNA 124-2) • MIR133B (MicroRNA 133b) • MIR145 (MicroRNA 145) • MIR124-3 (MicroRNA 124-3)

HER-2 positive

Herceptin (trastuzumab)

2ms

Heterogeneity study on MiRNA expression in islet cells of rat pancreatic head and tail. (PubMed, BMC Med Genomics)

Our findings provide novel insights into the heterogeneity of miRNA expression in the pancreas and the molecular mechanisms underlying pancreatic cancer, offering potential targets for future diagnostic and therapeutic strategies.

2 months ago

Preclinical • Journal

MIR124-3 (MicroRNA 124-3)

3ms

MicroRNA-124-3p suppresses lung cancer by targeting ITGB1/PI3K/p-AKT signal transduction pathway. (PubMed, Exp Cell Res)

Consistent with this, bioinformatics analysis demonstrated that miR-124-3p expression is significantly lower in tumor tissues than in adjacent normal lung and further decreases in advanced T stage (T3-T4) compared to early stage (T1-T2). These findings indicate that miR-124-3p inhibits NSCLC progression via the ITGB1/PI3K/p-AKT axis and remains functional despite PIK3CA activation, supporting its potential as a therapeutic candidate.

3 months ago

Journal

PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • ITGB1 (Integrin Subunit Beta 1) • MIR124-3 (MicroRNA 124-3)

PIK3CA mutation

3ms

Aberrant MicroRNA-124 expression and methylation in the dorsolateral prefrontal cortex of depressed subjects. (PubMed, J Psychiatr Res)

Furthermore, we identified a significant reduction in DNA methylation in one of the miR-124 promoter regions on chromosome 20 in MDD subjects. Our results provide new insights into the epigenetic regulation of miR-124-3p in the brains of MDD subjects and highlight its potential role in MDD pathophysiology.

3 months ago

Journal

MIR124-3 (MicroRNA 124-3)

4ms

Identification and validation of stage-specific microRNAs and target genes for prostate cancer: Utilizing bioinformatics tools for diagnostic marker discovery. (PubMed, PLoS One)

We also identified the tumor suppressor role of miR-17-5p, which was associated with higher Gleason scores. We propose PRC1, UBA52, RCC1, miR-124-3p and miR133a-3p as stage-specific PCa identifiers.

4 months ago

Journal

MIR17 (MicroRNA 17) • MIR33A (MicroRNA 33a) • MIR124-3 (MicroRNA 124-3)

4ms

miR-124 Targets EGFR and Attenuates Growth and Invasion in Bladder Cancer Cells. (PubMed, In Vivo)

miR-124-3p suppresses bladder cancer cells progression by directly targeting and inactivating EGFR, thereby impairing cell proliferation, migration, and invasion. These findings highlight miR-124-3p as a potential therapeutic agent in EGFR-driven bladder cancer.

4 months ago

Journal

EGFR (Epidermal growth factor receptor) • MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9) • MIR124-3 (MicroRNA 124-3)

erlotinib

4ms

Determination of Critical Genes and Key Regulatorys in Colorectal Cancer with Meta- and Network Analysis of Microarray Datasets. (PubMed, Adv Biomed Res)

The functional analysis revealed pathways significantly related to cancer progression. Employing systems biology approaches with holistic insight can identify essential genes and their regulation as possibilities for further experimental testing.

4 months ago

Journal

FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • SPI1 (Spi-1 Proto-Oncogene) • FOXA2 (Forkhead Box A2) • MIR16 (MicroRNA 16) • MIR92A1 (MicroRNA 92a-1) • MITF (Melanocyte Inducing Transcription Factor) • HNF1A (HNF1 Homeobox A) • MIR124-2 (MicroRNA 124-2) • SMAD3 (SMAD Family Member 3) • MIR124-3 (MicroRNA 124-3)

4ms

Pan-Cancer Analyses of Shared and Distinct Gene Expression in 17 Cancers: Rethinking Cancer Classification and Moving Beyond "One Drug, One Disease" Paradigm of Pharmaceutical Innovation. (PubMed, OMICS)

In conclusion, these findings provide system-level insights on tumor heterogeneity and inform future cancer classification, for example, according to shared and distinct molecular signatures and development of therapies that might prove effective across several cancers. We underline that unpacking molecular signatures across multiple cancers also offers new prospects to move beyond the "One Drug, One Disease" paradigm of pharmaceutical innovation.

4 months ago

Journal • Pan tumor

ABL1 (ABL proto-oncogene 1) • CDK2 (Cyclin-dependent kinase 2) • HDAC1 (Histone Deacetylase 1) • RELA (RELA Proto-Oncogene) • MIR124-3 (MicroRNA 124-3)