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    GENE:

    MIR1227 (MicroRNA 1227)

    i
    Other names: MIR1227, MicroRNA 1227, Hsa-Mir-1227, MIRN1227, Hsa-MiR-1227-3p , MIMAT0005580, MIMAT0022941, MI0006316, Mir-1227, RF01314
    Associations

    News

    Trials
    over1year
    Long noncoding RNA KCNMA1-AS2 regulates the function of colorectal cancer cells and sponges miR-1227-5p. (PubMed, BMC Cancer)
    LncRNA KCNMA1-AS2 exhibited distinct gene expression patterns in both CRC tissue and cell lines, impacting various cellular functions while also acting as a sponge for miR-1227-5p.The findings spotlight lncRNA KCNMA1-AS2 as a potential marker for diagnosis and treatment of CRC.
    Journal
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    MTHFR (Methylenetetrahydrofolate Reductase) • ANXA5 (Annexin A5) • MIR122 (MicroRNA 122) • MIR1227 (MicroRNA 1227)
    over3years
    Functional high-throughput screen identifies microRNAs that promote butyrate-induced death in colorectal cancer cells. (PubMed, Mol Ther Nucleic Acids)
    Several cancer-associated miRNA targets, including TRIM29, COX2, PIK3R3, CCND1, MET, EEF2K, DVL3, and NUP62 were synergistically regulated by the combination of cognate miRNAs and butyrate. Overall, this study has exposed the potential of miRNAs to act as enhancers of the anti-cancer effects of HDAC inhibition and identifies specific miRNAs that might be exploited for therapeutic benefit.
    Journal
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    CCND1 (Cyclin D1) • EEF2K (Eukaryotic Elongation Factor 2 Kinase) • NUP62 (Nucleoporin 62) • MIR122 (MicroRNA 122) • MIR1227 (MicroRNA 1227) • MIR181A1 (MicroRNA 181a-1) • PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3)
    almost4years
    A Study on microRNAs Targeting the Genes Overexpressed in Lung Cancer and their Codon Usage Patterns. (PubMed, Mol Biotechnol)
    Lastly, the functionalities of target genes were also revealed. The silencing characteristic of miRNAs might be exploited to design miRNA-mediated therapy that might potentially repress the overexpressed genes in carcinoma.
    Journal
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    MUC16 (Mucin 16, Cell Surface Associated) • COL1A1 (Collagen Type I Alpha 1 Chain) • FAT2 (FAT Atypical Cadherin 2) • MUC5B (Mucin 5B, Oligomeric Mucus/Gel-Forming) • MIR1290 (MicroRNA 1290) • MIR182 (MicroRNA 182) • MIR425 (MicroRNA 425) • COL5A1 (Collagen Type V Alpha 1 Chain) • MIR1205 (MicroRNA 1205) • MIR1207 (MicroRNA 1207) • MIR122 (MicroRNA 122) • MIR1227 (MicroRNA 1227) • MIR127 (MicroRNA 127) • MIR1304 (MicroRNA 1304) • MIR888 (MicroRNA 888)
    4years
    miR-1227 Targets SEC23A to Regulate the Shedding of Large Extracellular Vesicles. (PubMed, Cancers (Basel))
    The inhibition of SEC23A was sufficient to induce the shedding of large EVs. These results identify a novel mechanism of EV shedding, by which the inhibition of SEC23A by miR-1227 induces a shift in EV shedding, favoring the shedding of large EV over small EV.
    Journal
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    MIR122 (MicroRNA 122) • MIR1227 (MicroRNA 1227)