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MIR10B (MicroRNA 10b)

News alerts, weekly reports and conference planners

28d

Nanotherapy Targeting miR-10b Improves Survival in Orthotopic Glioblastoma Models. (PubMed, J Funct Biomater)

In therapeutic studies in orthotopic models of GBM presented here we used MN-anti-miR10b as well as TTX-MC138, a clinically tested anti-miR10b nanotherapeutic now in Phase I trials in patients with solid (non-GBM) cancers. Both formulations showed efficient delivery, as demonstrated by imaging and improved survival, leading to target inhibition and increased apoptosis. This approach may offer a novel strategy for delivering therapeutics to GBM and improving patient outcomes in one of the most aggressive and treatment-resistant forms of brain cancer.

28 days ago

Journal

MIR10B (MicroRNA 10b)

TTX-MC138

LINC00324 suppresses abnormal proliferation and promotes apoptosis of leukemia cells through the miR-10b-5p/PTEN pathway. (PubMed, Neoplasma)

LINC00324 regulates the proliferation and apoptosis of leukemia cells through the miR-10b-5p/PTEN axis. These findings add to the understanding of lncRNA-mediated regulatory mechanisms in leukemia.

1 month ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • MIR10B (MicroRNA 10b)

The TET/5hmC Mediated Epigenetic Landscape in Glioma: From Molecular Mechanisms to Therapeutic Targeting and Future Perspectives. (PubMed, Pharmacol Res)

We further identify critical research gaps, including single-cell and spatial mapping of TET/5hmC dynamics, microenvironmental regulation of TET activity, functional cooperation between TET isoforms, and the development of clinically feasible delivery systems and biomarkers. Addressing these challenges will be essential to translate TET pathway modulation into effective, individualized combination therapies for glioma patients.

1 month ago

Review • Journal

IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • TET2 (Tet Methylcytosine Dioxygenase 2) • STAT3 (Signal Transducer And Activator Of Transcription 3) • SOX2 • MIR10B (MicroRNA 10b)

Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)

The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.

1 month ago

Journal

TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)

2ms

Biological Logic-Gated DNA Self-Assembly Strategy for Precision Tumor Imaging and Selective Activation of the cGAS-STING Pathway. (PubMed, ACS Appl Mater Interfaces)

By employing endogenous tumor signals as logic inputs, this work presents an intelligent immunotherapy platform that integrates precise immune modulation with diagnostic feedback. Our study offers both a conceptual advance and a technological framework for designing programmable nucleic acid therapeutics that improve antitumor efficacy while minimizing off-target toxicity.

2 months ago

Journal • IO biomarker

STING (stimulator of interferon response cGAMP interactor 1) • CGAS (Cyclic GMP-AMP Synthase) • MIR10B (MicroRNA 10b)

2ms

Extracellular vesicles-derived non-coding RNA in leukemias and pre-leukemic syndromes: a systematic review. (PubMed, J Cancer Res Clin Oncol)

These findings highlight the transformative potential of exosomal ncRNAs in precision oncology, offering novel ways for non-invasive diagnostics, prognostic stratification, and targeted therapies in hematological malignancies. Additional studies are necessary to validate these biomarkers and explore their clinical applications.

2 months ago

Review • Journal

MIR21 (MicroRNA 21) • MIR494 (MicroRNA 494) • MIR10B (MicroRNA 10b) • MIR326 (MicroRNA 326) • MIR532 (MicroRNA 532)

3ms

Altered microRNA profiles and associated pathways in canine mammary adenocarcinoma. (PubMed, Sci Rep)

Pathway enrichment linked these deregulated miRNAs to key oncogenic networks, particularly PI3K/AKT/mTOR, Wnt/β-catenin, and EMT regulation, demonstrating conserved molecular mechanisms shared with human BC and highlighting their potential as biomarkers in CMTs. These findings provide insights into the molecular mechanisms of CMT adenocarcinoma and suggest the potential of miRNA-based biomarkers for the diagnosis and treatment of CMTs.

3 months ago

Journal

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • Let-7c (MicroRNA Let-7c) • MIR143 (MicroRNA 143) • MIR106B (MicroRNA 106b) • MIR10B (MicroRNA 10b) • MIR15A (MicroRNA 15a) • MIR191 (MicroRNA 191) • MIR205 (MicroRNA 205) • MIR26A1 (MicroRNA 26a-1) • MIR93 (MicroRNA 93)

3ms

Unraveling the role of the solute carrier family in hepatocellular carcinoma: mechanisms and therapeutic prospects. (PubMed, Cancer Cell Int)

It also examines how the metal ions in liver cancer impact HCC growth and the efficacy of anticancer immunotherapy. Furthermore, we discuss the vital role of SLCs as key transporters for the hepatic uptake of anionic anticancer drugs, highlighting novel therapeutic opportunities.

3 months ago

Review • Journal

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • SLC7A11 (Solute Carrier Family 7 Member 11) • LINC01559 (Long Intergenic Non-Protein Coding RNA 1559) • SMYD3 (SET And MYND Domain Containing 3) • MIR10B (MicroRNA 10b)

3ms

Identification and prognostic prediction of high-risk multiple myeloma by exosomal microRNA. (PubMed, Front Oncol)

This integrative model effectively predicted 1-, 3-, and 5-year survival probabilities, thereby stratifying patients into distinct risk categories for enhanced clinical decision-making and personalized follow-up strategies. This research validates the diagnostic and prognostic utility of exosomal miRNA models in MM, emphasizing their discriminative and predictive capabilities.

3 months ago

Journal

MIR192 (MicroRNA 192) • MIR193B (MicroRNA 193b) • MIR10B (MicroRNA 10b) • MIR148A (MicroRNA 148a) • MIR483 (MicroRNA 483) • MIRLET7B (MicroRNA Let-7b)

3ms

The Length of Lactation and Model of Weaning Modulate Key Regulatory Nodes of Murine Mammary Gland Involution. (PubMed, Int J Mol Sci)

These persistent molecular differences suggest spontaneous weaning as the optimal model for healthy mammary gland regression, whereas forced weaning sustains alterations in calpain-2 and regulatory miRs that may increase post-partum breast cancer risk. The potential long-term influence of lactation duration on breast cancer development warrants further consideration in both clinical and public health contexts.

3 months ago

Preclinical • Journal

MIR143 (MicroRNA 143) • CAPN1 (Calpain 1) • CAPN2 (Calpain 2) • MIR10B (MicroRNA 10b)

4ms

Tumor microenvironment in breast cancer: cellular crosstalk, pathways, and therapeutic insights. (PubMed, Mol Biol Rep)

In particular, the combination procedures with immunomodulation and TME disruption have demonstrated some success in conquering resistance in TNBC models. Therefore, it is paramount to understand how the surrounding tissue, the immune system, the immune system, and other elements behave over time and space as cofounding partners of tumors, in a way that would create better precision and clinical outcomes in breast cancer patients.

4 months ago

Review • Journal

HIF1A (Hypoxia inducible factor 1, alpha subunit) • IL10 (Interleukin 10) • MIR21 (MicroRNA 21) • MIR10B (MicroRNA 10b)

4ms

Extracellular Vesicle-Derived miRNAs as Diagnostic Biomarkers for Pancreatic Ductal Adenocarcinoma: A Systematic Review of Methodological Rigour and Clinical Applicability. (PubMed, Biomark Insights)

EV-derived miRNAs are promising PDAC biomarkers, but progress is hindered by inconsistent methods, poor EV validation, and minimal external verification. Translation to clinical use requires robust EV characterisation, standardised workflows, and prospective multi-cohort studies.

4 months ago

Review • Journal

MIR21 (MicroRNA 21) • MIR451A (MicroRNA 451a) • MIR10B (MicroRNA 10b)