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    BIOMARKER:

    miR-92a-1 expression

    i
    Other names: MIR92A1, MicroRNA 92a-1, Hsa-MiR-92a-1-5p, Hsa-MiR-92a-3p, MicroRNA 92-1, Hsa-Mir-92a-1, Hsa-Mir-92-1, MIR92A1, Putative MicroRNA 17 Host Gene Protein, Putative MicroRNA Host Gene 1 Protein, Hsa-Mir-92-P1a, MIRN92A-1, MiRNA92-1, Mir-92a-1, C13orf25, MIRN92-1, MIRN92A1, MIR17HG, MIR92-1, MIRHG1, MIRH1
    Entrez ID:
    407048
    over1year
    LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p. (PubMed, Mol Biotechnol)
    These novel findings indicate that MIR17HG may be a potential target for breast cancer. Our findings demonstrated that MIR17HG might suppress breast cancer cell proliferation and migration by sponge miR-454-3p through ceRNA(competing endogenous RNAs) mechanism, indicating that targeting MIR17HG may be a feasible therapeutic candidate for breast cancer.
    Journal
    |
    MIR17HG (MiR-17-92a-1 Cluster Host Gene) • MIR92A1 (MicroRNA 92a-1) • MIR454 (MicroRNA 454)
    |
    miR-92a-1 expression
    almost2years
    Prognostic Value of the miR-17~92 Cluster in Chronic Lymphocytic Leukemia. (PubMed, Int J Mol Sci)
    Particularly, miR-20a could be considered an independent favorable prognostic factor. In a multivariate analysis, high miR-20a expression remained an independent marker predicting long TTT (time to treatment) for CLL patients.
    Journal • IO biomarker
    |
    CD19 (CD19 Molecule) • CD38 (CD38 Molecule) • MIR17 (MicroRNA 17) • MIR18A (MicroRNA 18a) • MIR19B1 (MicroRNA 19b-1) • MIR92A1 (MicroRNA 92a-1) • MIR19A (MicroRNA 19a) • MIR20A (MicroRNA 20a)
    |
    Chr del(11q) • miR-92a-1 expression
    almost3years
    LncRNA MIR17HG promotes the proliferation, migration, and invasion of retinoblastoma cells by up-regulating HIF-1α expression via sponging miR-155-5p. (PubMed, Kaohsiung J Med Sci)
    Additionally, miR-155-5p was identified as a target of MIR17HG. The data in this study suggest that MIR17HG exerts oncogenic effects in RB via the miR-155-5p/HIF-1α axis.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • MIR155 (MicroRNA 155) • MIR17HG (MiR-17-92a-1 Cluster Host Gene) • MIR17 (MicroRNA 17) • MIR92A1 (MicroRNA 92a-1)
    |
    miR-155 expression • HIF1A expression • miR-92a-1 expression
    over3years
    LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit. (PubMed, Oncogene)
    More interestingly, lactate accumulated via glycolysis activated the p38/Elk-1 signaling pathway to promote the transcriptional expression of MIR17HG in CRC cells, forming a positive feedback loop, which eventually resulted in persistent glycolysis and the invasion and liver metastasis of CRC cells. In conclusion, the present study indicates that the lactate-responsive lncRNA MIR17HG, acting as a ceRNA, promotes CRLM through a glycolysis-mediated positive feedback circuit and might be a novel biomarker and therapeutic target for CRLM.
    Journal
    |
    MIR17HG (MiR-17-92a-1 Cluster Host Gene) • MIR92A1 (MicroRNA 92a-1)
    |
    miR-92a-1 expression