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    BIOMARKER:

    miR-660 expression

    i
    Other names: MIR660, MicroRNA 660, Hsa-MiR-660-5p, Hsa-MiR-660-3p, Hsa-Mir-660, MIR660, Hsa-Mir-188-P3, MIRN660, Mir-660
    Entrez ID:
    724030
    1year
    Decreased KLF3 Expression via miR-660-5p Targeting Suppresses Gastric Cancer Cell Progression. (PubMed, Ann Clin Lab Sci)
    This study firstly reported the miR-660-5p/KLF3 interaction in GC, and the results provided a potential promising therapeutic target for GC.
    Journal
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    MIR660 (MicroRNA 660)
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    miR-660 expression
    over1year
    microRNA-660 Enhances Cisplatin Sensitivity via Decreasing SATB2 Expression in Lung Adenocarcinoma. (PubMed, Genes (Basel))
    We also revealed that miR-660 increased cisplatin sensitivity in LUAD cells via targeting SATB2. In conclusion, miR-660/SATB2 axis is a key regulator of cisplatin resistance in LUAD.
    Journal
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    MIR660 (MicroRNA 660) • SATB2 (SATB Homeobox 2)
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    miR-660 expression
    |
    cisplatin
    almost2years
    Revealing the role of microRNAs in the emergence of cancer stem cell heterogeneity during colorectal cancer progression (AACR 2023)
    Taken together, these results indicate that expression of miR-660-3p, by inhibiting RXRA expression, increases WNT signaling and decreases RA signaling in LGR5+/ALDH- CSCs. Thus, upregulated miR-660-3p targets a key gene in the RA signaling pathway (RXRA) which could contribute to the emergence of SC sub-populations during CRC development.
    Cancer stem
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • MIR660 (MicroRNA 660) • RXRA (Retinoid X Receptor Alpha) • LGR5 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 5)
    |
    miR-660 expression
    almost3years
    Tumor-promoting mechanisms of macrophage-derived extracellular vesicles-enclosed microRNA-660 in breast cancer progression. (PubMed, Breast Cancer Res Treat)
    Taken altogether, our work shows that TAMs-EVs-shuttled miR-660 promotes breast cancer progression through KLHL21-mediated IKKβ/NF-κB p65 axis.
    Journal
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    MIR660 (MicroRNA 660)
    |
    miR-660 expression
    almost4years
    miR-660-5p promotes breast cancer progression through down-regulating TET2 and activating PI3K/AKT/mTOR signaling. (PubMed, Braz J Med Biol Res)
    miR-660-5p promoted BC progression partly through modulating TET2 and PI3K/AKT/mTOR signaling. miR-660-5p/TET2 axis might be a promising target for BC treatment.
    Journal
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    TET2 (Tet Methylcytosine Dioxygenase 2) • MIR660 (MicroRNA 660)
    |
    miR-660 expression