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    BIOMARKER:

    miR-504 expression

    i
    Other names: MIR504, MicroRNA 504, Hsa-Mir-504, MIR504, Hsa-Mir-504-V2, Hsa-Mir-504-V1, Hsa-MiR-504-5p, MIRN504, Mir-504
    Entrez ID:
    574507
    over1year
    Downregulation of the long noncoding RNA DSCR9 (Down syndrome critical region 9) delays breast cancer progression by modulating microRNA-504-5p-dependent G protein-coupled receptor 65. (PubMed, Hum Cell)
    Finally, animal study verified that depletion of DSCR9 inhibited the proliferation of BCSCs in vivo and that BCSC proliferation was restored by overexpression of GPR65. Altogether, our findings revealed that DSCR9 elevated GPR65 expression by targeting miR-504-5p to exacerbate breast cancer, highlighting a new treatment modality for breast cancer.
    Journal
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    MIR504 (MicroRNA 504)
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    miR-504 expression
    over2years
    MiR-504-3p Has Tumor-Suppressing Activity and Decreases IFITM1 Expression in Non-Small Cell Lung Cancer Cells. (PubMed, Genet Test Mol Biomarkers)
    miR-504-3p inhibits cell proliferation and migration and promotes cell apoptosis in NSCLC cells. MiR-504-3p decreases IFITM1 expression in NSCLC cells, which may be a potential mechanism of its tumor-suppressive functions in NSCLC.
    Journal
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    MIR504 (MicroRNA 504)
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    miR-504 expression
    over3years
    miR-504 Promoted Gastric Cancer Cell Proliferation and Inhibited Cell Apoptosis by Targeting RBM4. (PubMed, J Immunol Res)
    miR-504 was further confirmed to promote SGC-7901 cell proliferation and inhibit cell apoptosis by downregulation RBM4 in vitro. miR-504 promotes gastric cancer cell proliferation and inhibits cell apoptosis by targeting RBM4, and this provides a potential diagnostic biomarker and treatment for patients with gastric cancer.
    Journal
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    MIR504 (MicroRNA 504)
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    miR-504 expression
    almost4years
    LncRNA ROR1-AS1 accelerates osteosarcoma invasion and proliferation through modulating miR-504. (PubMed, Aging (Albany NY))
    MiR-504 overexpression partly abrogated ROR1-AS1-induced effects on osteosarcoma cell migration and proliferation. These data implied that ROR1-AS1 played as an oncogene and might be a new treatment target for osteosarcoma.
    Journal
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    CCND1 (Cyclin D1) • ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) • CDH1 (Cadherin 1) • VIM (Vimentin) • PCNA (Proliferating cell nuclear antigen) • MIR504 (MicroRNA 504)
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    ROR1 expression • CCND1 expression • CDH1 expression • VIM expression • miR-504 expression • PCNA expression
    4years
    Bladder cancer-associated transcript 2 contributes to nephroblastoma progression. (PubMed, J Gene Med)
    Our study revealed that a novel BLACAT2/miR-504-3p/Wnt11 axis is associated with nephroblastoma, where BLACAT2 is able to sponge miR-504-3p to down-regulate Wnt11.
    Journal
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    MIR504 (MicroRNA 504)
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    miR-504 expression