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    BIOMARKER:

    miR-494 overexpression

    i
    Other names: MIR494, MicroRNA 494, Hsa-Mir-494, MIRN494, Hsa-Mir-154-P18, Hsa-MiR-494-3p, MIMAT0026607, MIMAT0002816, MI0003134, Mir-494, RF00641
    Entrez ID:
    574452
    2years
    JAK1 Is a Novel Target of Tumor- and Invasion-Suppressive microRNA 494-5p in Colorectal Cancer. (PubMed, Cancers (Basel))
    A Kaplan-Meier plotter analysis revealed that patients with high JAK1 expression show reduced survival. Together, these data suggest that miR-494-5p physically inhibits the expression of JAK1 at the translational level as well as in migration and invasion, supporting the hypothesis of miR-494-5p as an early tumor suppressor and inhibitor of early steps of metastasis in CRC.
    Journal
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    JAK1 (Janus Kinase 1) • STAT6 (Signal transducer and activator of transcription 6) • IL4 (Interleukin 4) • MIR494 (MicroRNA 494)
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    miR-494 overexpression
    over2years
    Astaxanthin protects against pirarubicin-induced H9c2 cardiomyocytes by adjusting microRNA-494-3p-mediated MDM4/p53 signalling pathway. (PubMed, J Pharm Pharmacol)
    AST can inhibit H9c2 apoptosis induced by THP and attenuate H9c2 damage by THP, which may be achieved by downregulating miR-494-3p, upregulating MDM4, and inhibiting p53.
    Journal
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    MDM4 (The mouse double minute 4) • MIR494 (MicroRNA 494)
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    TP53 expression • miR-494 overexpression
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    Pinorubin (pirarubicin)
    over3years
    Tangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers (SABCS 2022)
    We observed large-scale genome-wide alterations in MRN-deficient tumourscontributing to aggressive behaviour. We conclude that MRN status may be a useful tool tostratify tumours for precision medicine strategies.
    Clinical • BRCA Biomarker • PARP Biomarker
    |
    ER (Estrogen receptor) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • ERCC1 (Excision repair cross-complementation group 1) • CHEK2 (Checkpoint kinase 2) • RAD51 (RAD51 Homolog A) • RAD50 (RAD50 Double Strand Break Repair Protein) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • MRE11A (MRE11 homolog, double strand break repair nuclease) • WRN (WRN RecQ Like Helicase) • RECQL5 (RecQ Like Helicase 5) • MIR494 (MicroRNA 494) • RECQL (RecQ Like Helicase) • RECQL4( RecQ Like Helicase 4) • RPA1 (Replication Protein A1) • RPA2 (Replication Protein A2) • XRCC1 (X-Ray Repair Cross Complementing 1) • FEN1 (Flap Structure-Specific Endonuclease 1) • MIR99B (MicroRNA 99b)
    |
    miR-494 overexpression
    over3years
    Extracellular Polysaccharide from Rhizopus nigricans Inhibits Hepatocellular Carcinoma via miR-494-3p/TRIM36 Axis and Cyclin E Ubiquitination. (PubMed, J Clin Transl Hepatol)
    EPS1-1 suppressed cyclin E expression, promoted TRIM36 expression and tumor apoptosis, all of which were abrogated by increasing the expression of miR-494-3p in vivo. EPS1-1 protected against HCC by limiting its proliferation and survival through the miR-494-3p/TRIM36 axis and by inducing cyclin E ubiquitination.
    Journal
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    CDKN1A (Cyclin-dependent kinase inhibitor 1A) • MIR494 (MicroRNA 494)
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    TRIM3 overexpression • miR-494 overexpression
    over3years
    Hypoxia induces docetaxel resistance in triple-negative breast cancer via the HIF-1α/miR-494/Survivin signaling pathway. (PubMed, Neoplasia)
    Cytotoxic chemotherapy is the major strategy to prevent and reduce triple-negative breast cancer (TNBC) progression and metastasis. Finally, in a xenograft model, both miR-494 overexpression and the HIF-1α inhibitor PX-478 increased the sensitivity of TNBC to DTX by suppressing the HIF-1α/miR-494/Survivin signaling pathway in vivo. In conclusion, treatments targeting the HIF-1α/miR-494/Survivin signaling pathway potentially reverse hypoxia-induced drug resistance in TNBC.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • BIRC5 (Baculoviral IAP repeat containing 5) • MIR494 (MicroRNA 494)
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    HIF1A overexpression • BIRC5 expression • HIF1A expression • miR-494 overexpression
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    docetaxel • PX-478
    almost4years
    Silencing of histone deacetylase 3 suppresses the development of esophageal squamous cell carcinoma through regulation of miR-494-mediated TGIF1. (PubMed, Cancer Cell Int)
    Collectively, our findings provided demonstration regarding the oncogenic property of HDAC3 in ESCC via the miR-494/TGIF1/TGFβ axis.
    Journal • Epigenetic controller
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    MIR494 (MicroRNA 494) • HDAC3 (Histone Deacetylase 3)
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    miR-494 overexpression
    almost4years
    LncRNA PCAT29 Up-Regulates the Expression of PTEN by Down-Regulating miR-494 in Non-Small-Cell Lung Cancer to Suppress Tumor Progression. (PubMed, Crit Rev Eukaryot Gene Expr)
    miR-494 played an opposite role and attenuated the effects of overexpression of PCAT29. Therefore, PCAT29 may up-regulate PTEN by down-regulating miR-494 to suppress the progression of NSCLC cells.
    Journal
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    PTEN (Phosphatase and tensin homolog) • MIR494 (MicroRNA 494)
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    PTEN expression • miR-494 overexpression
    4years
    Circ_0000745 promotes acute lymphoblastic leukemia progression through mediating miR-494-3p/NET1 axis. (PubMed, Hematology)
    Circ_0000745 can positively regulate NET1 expression by sponging miR-494-3p in ALL cells. Circ_0000745 contributed to ALL development partly by binding to miR-494-3p to induce NET1 expression.0020.
    Journal
    |
    MIR494 (MicroRNA 494) • SPECC1 (Sperm Antigen With Calponin Homology And Coiled-Coil Domains 1)
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    miR-494 overexpression
    4years
    lncRNA NR2F2-AS1 inhibits the methylation of miR-494 to regulate oral squamous cell carcinoma cell proliferation. (PubMed, Arch Oral Biol)
    NR2F2-AS1 may inhibit miR-494 methylation to regulate cell proliferation in OSCC.
    Journal
    |
    MIR494 (MicroRNA 494)
    |
    miR-494 overexpression
    over4years
    Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers. (PubMed, NPJ Breast Cancer)
    We observed large-scale genome-wide alterations in MRN-deficient tumours contributing to aggressive behaviour. We conclude that MRN status may be a useful tool to stratify tumours for precision medicine strategies.
    Clinical • Journal • BRCA Biomarker • PARP Biomarker
    |
    ER (Estrogen receptor) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • ERCC1 (Excision repair cross-complementation group 1) • CHEK2 (Checkpoint kinase 2) • RAD51 (RAD51 Homolog A) • RAD50 (RAD50 Double Strand Break Repair Protein) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • WRN (WRN RecQ Like Helicase) • RECQL5 (RecQ Like Helicase 5) • MIR494 (MicroRNA 494) • RECQL (RecQ Like Helicase) • RECQL4( RecQ Like Helicase 4) • RPA1 (Replication Protein A1) • RPA2 (Replication Protein A2) • XRCC1 (X-Ray Repair Cross Complementing 1) • FEN1 (Flap Structure-Specific Endonuclease 1)
    |
    miR-494 overexpression