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    BIOMARKER:

    miR-363 expression

    i
    Other names: MIR363, MicroRNA 363, Hsa-MiR-363-3p, Hsa-MiR-363-5p, Hsa-Mir-363, MIR-363, MIR363, Hsa-Mir-92-P2b, MIRN363
    Entrez ID:
    574031
    1year
    MicroRNA-363-3p inhibits colorectal cancer progression by targeting interferon-induced transmembrane protein 1. (PubMed, World J Gastrointest Oncol)
    MiR-363-3p can constrain clonogenic survival, proliferation, and migration of colorectal cancer cells via targeting IFITM1.
    Journal
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    MIR363 (MicroRNA 363)
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    miR-363 expression
    over2years
    MicroRNA-363-3p, negatively regulated by long non-coding RNA small nucleolar RNA host gene 5, inhibits tumor progression by targeting Aurora kinase A in colorectal cancer. (PubMed, Bioengineered)
    Besides, miR-363-3p was sponged by long non-coding RNA small nucleolar RNA host gene 5 (SNHG5), which suppressed miR-363-3p expression. This research shows that SNHG5/miR-363-3p/AURKA axis partakes in CRC progression.
    Journal
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    AURKA (Aurora kinase A) • MIR363 (MicroRNA 363) • SNHG5 (Small Nucleolar RNA Host Gene 5)
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    miR-363 expression
    3years
    Reduced miR-363-3p expression in non-small cell lung cancer is associated with gemcitabine resistance via targeting of CUL4A. (PubMed, Eur Rev Med Pharmacol Sci)
    The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/16879.
    Journal
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    CUL4A (Cullin 4A) • MIR363 (MicroRNA 363)
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    miR-363 expression
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    gemcitabine
    3years
    Effect of tumor-associated macrophages on lncRNA PURPL/miR-363/PDZD2 axis in osteosarcoma cells. (PubMed, Cell Death Discov)
    The silence of PDZD2 weakened the influences of PURPL overexpression on MG-63 cells and TAMs migration. On modulating the PURPL/miR-363/PDZD2 axis, TAMs-promoted OS development might be achieved.
    Journal
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    TP53 (Tumor protein P53) • CD14 (CD14 Molecule) • MIR363 (MicroRNA 363)
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    miR-363 expression
    3years
    miR-363-3p induces EMT via the Wnt/β-catenin pathway in glioma cells by targeting CELF2. (PubMed, J Cell Mol Med)
    Treatment with ASO-miR-363-3p decreased tumour size and weight in nude mice. In conclusion, miR-363-3p induced the EMT, which resulted in increased migration and invasion and reduced apoptosis in glioma cell lines, via the Wnt/β-catenin pathway by targeting CELF2.
    Journal
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    CELF2 (CUGBP Elav-Like Family Member 2) • MIR363 (MicroRNA 363)
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    miR-363 expression
    over3years
    LncRNA FEZF1-AS1 promotes colorectal cancer progression through regulating the miR-363-3p/PRRX1 pathway. (PubMed, Adv Clin Exp Med)
    Our data demonstrate that FEZF1-AS1 regulated PRRX1 expression to promote CRC progression via inhibition of miR-363-3p.
    Journal
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    MIR363 (MicroRNA 363) • PRRX1 (Paired Related Homeobox 1)
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    miR-363 expression
    over3years
    Propofol inhibits the proliferation, migration, invasion and epithelial to mesenchymal transition of renal cell carcinoma cells by regulating microRNA-363/Snail1. (PubMed, Am J Transl Res)
    Our study found that propofol could inhibit invasion, migration, proliferation and EMT of RCC cells by promoting miR-363 expression and suppressing Snail1 expression.
    Journal
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    CDH1 (Cadherin 1) • VIM (Vimentin) • MIR363 (MicroRNA 363)
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    CDH1 expression • VIM expression • miR-363 expression
    over3years
    MicroRNA-363-3p inhibits tumor cell proliferation and invasion in oral squamous cell carcinoma cell lines by targeting SSFA2. (PubMed, Exp Ther Med)
    SSFA2 was verified as a direct target of miR-363-3p, and SSFA2 overexpression partially counteracted the inhibitory effects of miR-363-3p on cell proliferation, migration and invasion in OSCC cell lines. Thus, miR-363-3p may serve as a tumor suppressor via targeting SSFA2 and may represent a potential therapeutic target for OSCC.
    Preclinical • Journal
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    MIR363 (MicroRNA 363)
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    miR-363 expression
    over3years
    LncRNA NORAD, sponging miR-363-3p, promotes invasion and EMT by upregulating PEAK1 and activating the ERK signaling pathway in NSCLC cells. (PubMed, J Bioenerg Biomembr)
    In addition, p-ERK expression was detected by Western blotting to observe the effects of lncRNA NORAD, miR-363-3p and PEAK1 on activation of the ERK signaling pathway. Taken together, lncRNA NORAD upregulated the expression of PEAK1 through sponging miR-363-3p, and then activated the ERK signaling pathway, thereby promoting the development of NSCLC.
    Journal
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    MAPK1 (Mitogen-activated protein kinase 1) • MIR363 (MicroRNA 363)
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    miR-363 expression
    4years
    miR-363 Alleviates Detrusor Fibrosis via the TGF-β1/Smad Signaling Pathway by Targeting Col1a2 in Rat Models of STZ-Induced T2DM. (PubMed, Mol Ther Nucleic Acids)
    In conclusion, miR-363 upregulation reduces detrusor fibrosis in rats with STZ-induced T2DM through suppression of the TGF-β1/Smad signaling pathway by targeting Col1a2. Therefore, our study provided further insights for the development of new therapeutic targets for T2DM.
    Preclinical • Journal
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    SMAD4 (SMAD family member 4) • BAX (BCL2-associated X protein) • MIR363 (MicroRNA 363) • SMAD7 (SMAD Family Member 7)
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    SMAD4 expression • miR-363 expression