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    BIOMARKER:

    miR-324-5p overexpression

    i
    Other names: MIR324, MicroRNA 324, Hsa-Mir-324, Hsa-MiR-324-5p, Hsa-MiR-324-3p, MIRN324
    Entrez ID:
    442898
    Related biomarkers:
    Expression
    over4years
    MicroRNA-324-5p-CUEDC2 Axis Mediates Gain-of-Function Mutant p53-Driven Cancer Stemness. (PubMed, Mol Cancer Res)
    Thus, our study delineates an altered miR-324-5p-CUEDC2-NF-κB pathway as a novel regulator of GOF mutant p53-driven cancer stemness. Implications: Our findings implicate microRNA-324-5p as a novel epigenetic modifier of human cancer stemness.
    Journal
    |
    TP53 (Tumor protein P53) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • MIR324 (MicroRNA 324)
    |
    TP53 mutation • MYC expression • miR-324-5p overexpression
    almost5years
    Ginsenoside 20(S)-Rg3 suppresses cell viability in esophageal squamous cell carcinoma via modulating miR-324-5p-targeted PSME3. (PubMed, Hum Exp Toxicol)
    Further exploration verified that miR-324-5p targeted PSME3, and PSME3 deficiency countervailed the effect of miR-324-5p inhibition on ESCC cell viability under 20(S)-Rg3 treatment. Conclusively, 20(S)-Rg3 suppresses cell viability in ESCC via mediating miR-324-5p-targeted PSME3.
    Journal
    |
    MIR324 (MicroRNA 324)
    |
    miR-324-5p overexpression