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    BIOMARKER:

    miR-30d expression

    i
    Other names: miR-30d, MicroRNA 30d, Hsa-MiR-30d-3p, Hsa-MiR-30d-5p, Hsa-Mir-30d, MIR30D, Hsa-Mir-30-P1c, MIMAT0004551, MIMAT0000245, MI0000255, MIRN30D, Mir-30d, RF00131
    Entrez ID:
    407033
    2years
    Construction and analysis of pseudogene-related ceRNA network in breast cancer. (PubMed, Sci Rep)
    In addition, the oncogenic properties of MCF-7 (cell viability, clonogenicity, and migration) were improved after GBP1P1 overexpression. In conclusion, we report a ceRNA network that may provide new insight into the role of pseudogenes in BC development.
    Journal
    |
    GBP1 (Guanylate Binding Protein 1) • MIR30D (MicroRNA 30d)
    |
    miR-30d expression
    over3years
    Differential expression of miRNAs related to autophagy pathway in tissue and serum samples of colorectal cancer patients. (PubMed, Bratisl Lek Listy)
    The beclin 1 gene may play a role as a tumor suppressor in CRC. Moreover, these miRNAs cannot be used as highly reliable biomarkers in serum for CRC diagnosis (Tab. 2, Fig. 6, Ref. 46).
    Journal
    |
    MIR30B (MicroRNA 30b) • MIR17 (MicroRNA 17) • MIR216A (MicroRNA 216a) • MIR30D (MicroRNA 30d) • BECN1 (Beclin 1)
    |
    miR-30d expression
    over4years
    High miR-30 Expression Associates with Improved Breast Cancer Patient Survival and Treatment Outcome. (PubMed, Cancers (Basel))
    We conducted a two-stage drug-screen to investigate the impact of miR-30 family members (miR-30a-30e) on sensitivity to doxorubicin and lapatinib in six breast cancer cell lines HCC1937, HCC1954, MDA-MB-361, MCF7, MDA-MB-436 and CAL-120, using drug sensitivity scores (DSS) to compare the miR-30 family mimics to their specific inhibitors. According to the pathway analysis, the miR-30 family has a suppressive effect on cell motility and metastasis in breast cancer. Our results suggest prognostic and predictive potential for the miR-30 family, which warrants further investigation.
    Clinical • Journal
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • MIR30D (MicroRNA 30d) • MIR30E (MicroRNA 30e)
    |
    HER-2 positive • ER negative • miR-30d expression
    |
    lapatinib • doxorubicin hydrochloride • acalisib (GS-9820)
    almost5years
    YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect. (PubMed, Cell Death Differ)
    Overall, we demonstrated that miR-30d is a functional and clinical tumor-suppressive gene in PDAC. Our findings further uncover that miR-30d is a novel target for YTHDC1 through mA modification, and miR-30d represses pancreatic tumorigenesis via suppressing aerobic glycolysis.
    Journal
    |
    RUNX1 (RUNX Family Transcription Factor 1) • HK1 (Hexokinase 1) • MIR30D (MicroRNA 30d)
    |
    miR-30d expression