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    BIOMARKER:

    miR-206 overexpression

    i
    Other names: MIR206, MicroRNA 206, Hsa-Mir-206, MIR206, Hsa-Mir-1-P3, MIMAT0000462, Hsa-MiR-206, MI0000490, MiRNA206, MIRN206, Mir-206, RF00103
    Entrez ID:
    406989
    over1year
    MicroRNA-206 overexpression is associated with a prominent inflammatory reaction and a favorable colorectal cancer prognosis. (PubMed, Pathol Res Pract)
    Thus, MicroRNA-206 expression presents a feasible prognostic factor and potential therapeutic target to treat patients with colorectal cancer.
    Journal
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    MIR206 (MicroRNA 206)
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    miR-206 overexpression
    2years
    Interaction between miR‑206 and lncRNA MALAT1 in regulating viability and invasion in hepatocellular carcinoma. (PubMed, Oncol Lett)
    Collectively, this study presented evidence that miR-206 was controlled by lncRNA MALAT1 and partially suppressed the proliferation and invasion of HCC through the c-Met/Akt/mTOR signaling pathway. According to these results, understanding MALAT1/miR-206-dependent regulation may lead to potential approaches for diagnosis and prospective treatment of HCC.
    Journal
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    MET (MET proto-oncogene, receptor tyrosine kinase) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • MIR206 (MicroRNA 206)
    |
    miR-206 overexpression
    almost4years
    circ_AKT3 knockdown suppresses cisplatin resistance in gastric cancer. (PubMed, Open Med (Wars))
    Also, circ_AKT3 knockdown decreased xenograft tumor growth. circ_AKT3 knockdown suppressed cisplatin resistance using miR-206/PTPN14 axis in cisplatin-resistant GC cells.
    Journal
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    PTPN1 (Protein Tyrosine Phosphatase Non-Receptor Type 1) • MIR206 (MicroRNA 206)
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    miR-206 overexpression
    |
    cisplatin
    4years
    Targeting of PFKFB3 with miR-206 but not mir-26b inhibits ovarian cancer cell proliferation and migration involving FAK downregulation. (PubMed, FASEB J)
    3PO did not prevent miR-26b-induced SKOV3 migration. Overall, these results support the inverse relation between endogenous miRNA levels and their tumor-suppressive effects and suggest that restoring miR-206 expression represents a potential dual anti-PFKFB3/FAK strategy to control ovarian cancer progression.
    Journal
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    MIR206 (MicroRNA 206)
    |
    miR-206 overexpression
    4years
    miR-206 Inhibits Laryngeal Carcinoma Cell Multiplication, Migration, and Invasion. (PubMed, J Healthc Eng)
    Moreover, SOX9 was a target of miR-206, and miR-206 negatively regulated SOX9 expression. Collectively, miR-206 might be a promising biomarker with diagnostic and prognostic value for LC, and the miR-206/SOX9 axis might be a candidate target for LC therapy.
    Journal
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    SOX9 (SRY-Box Transcription Factor 9) • MIR206 (MicroRNA 206)
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    SOX9 expression • miR-206 overexpression
    over4years
    microRNA-206 Suppresses Cholangiocarcinoma Cell Growth and Invasion by Targeting Jumonji AT-Rich Interactive Domain 2. (PubMed, Dig Dis Sci)
    Altogether, our findings clarified that miR-206 inhibited CCA malignancy by negatively regulating JARID2.
    Journal
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    VIM (Vimentin) • MIR206 (MicroRNA 206)
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    VIM expression • miR-206 overexpression