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    BIOMARKER:

    miR-200c-3p overexpression

    i
    Other names: mir-200c, MicroRNA 200c, Hsa-MiR-200c-5p, Hsa-MiR-200c-3p, Hsa-Mir-200c, MIRN200C, MIR200C
    Entrez ID:
    406985
    Related biomarkers:
    Expression
    over1year
    MicroRNA mimics can distort physiological microRNA effects on immune checkpoints by triggering an antiviral interferon response. (PubMed, RNA Biol)
    Besides upregulating the ICs, this had substantial cellular consequences including an induction of interferon type I and type III expression, increased levels of intracellular dsRNA sensors, and a significantly altered cellular growth and apoptotic activity.Our study highlights the capability of miRNA mimics to non-specifically induce a dsRNA-mediated antiviral interferon response. Consequently, phenotypic alterations crucially distort physiological miRNA functions and might result in a major misinterpretation of previous and future miRNA studies, especially in the context of IC regulation.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    IDO1 (Indoleamine 2,3-dioxygenase 1) • MIR200C (MicroRNA 200c) • LGALS9 (Galectin 9) • MIR200 (MicroRNA 200)
    |
    miR-200-c overexpression • miR-200c-3p overexpression