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    BIOMARKER:

    miR-199b overexpression

    i
    Other names: MIR199B, MicroRNA 199b, Hsa-Mir-199b, Hsa-MiR-199a-3p, Hsa-MiR-199b-3p, Hsa-MiR-199b-5p, MIRN199B, Hsa-Mir-199-P1-V3, Hsa-Mir-199-P1-V2, Hsa-Mir-199-P1-V1, MIMAT0004563, MIMAT0000263, MI0000282, Mir-199b, RF00144
    Entrez ID:
    406978
    Related biomarkers:
    Expression
    2years
    The mir-199b-5p encapsulated in adipocyte-derived exosomes mediates radioresistance of colorectal cancer cells by targeting JAG1. (PubMed, Heliyon)
    It was demonstrated that JAG1 conferred the radioresistance of colorectal cancer cells both in vivo and in vitro. Taken together, the present study demonstrates that adipocytes trigger the radioresistance of colorectal cancer cells, probably by targeting JAG1 through an adipocyte-derived exosomal miR-199b-5p.
    Journal
    |
    MIR199B (MicroRNA 199b) • JAG1 (Jagged Canonical Notch Ligand 1)
    |
    miR-199b overexpression
    over2years
    hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway. (PubMed, Sci Rep)
    Concomitantly, it impeded the Wnt/beta-catenin pathway and the epithelial-to-mesenchymal transition process. Overall, the results of the present study emphasized the pivotal role of the miR-199b-3p in the formation and progression of OS, suggesting that it could be used as a potential tumor biomarker.
    Journal
    |
    MIR199A1 (MicroRNA 199a-1) • MIR199B (MicroRNA 199b)
    |
    miR-199b overexpression
    over3years
    The role of AURKA/miR-199b-3p in hepatocellular carcinoma cells. (PubMed, J Clin Lab Anal)
    To summarize, this study implied the regulatory mechanism of miR-199b-3p/AURKA axis in HCC, and supplied optional therapeutic targets for HCC patients.
    Journal
    |
    AURKA (Aurora kinase A) • MIR199B (MicroRNA 199b)
    |
    AURKA overexpression • miR-199b overexpression • AURKA expression