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    BIOMARKER:

    miR-192 expression

    i
    Other names: miR-192, MicroRNA 192, Hsa-MiR-192-5p, Hsa-MiR-192-3p, Hsa-Mir-192, MIR192, Hsa-Mir-192-P1, MIMAT0004543, MIMAT0000222, MI0000234, MiRNA192, MIRN192, MiR-192, RF00130
    Entrez ID:
    406967
    Related biomarkers:
    Expression
    over1year
    Modulation of miR-192/NF-κB/ TGF-β/ E-cadherin by thymoquinone protects against diethylnitrosamine /carbon tetrachloride hepatotoxicity. (PubMed, Physiol Int)
    In conclusion, thymoquinone protected the liver tissues through preserving miR-192 and E-cadherin and aborting NF-κB & TGF-β signaling. The current results highlight a new role for thymoquinone in preventing hepatic tumorigenesis.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CDH1 (Cadherin 1) • AFP (Alpha-fetoprotein) • BAX (BCL2-associated X protein) • TGFB1 (Transforming Growth Factor Beta 1) • MIR192 (MicroRNA 192)
    |
    BCL2 expression • CDH1 expression • BAX expression • CCL4 elevation • miR-192 expression
    2years
    MiR-192/NKRF axis confers lung cancer cell chemoresistance to cisplatin via the NF-κB pathway. (PubMed, Thorac Cancer)
    MiR-192 plays a crucial role in cisplatin-resistance of lung cancer cells. Thus, MiR-192 may represent a therapeutic target for overcoming resistance to cisplatin-based chemotherapy in lung cancer.
    Journal
    |
    BCL2L1 (BCL2-like 1) • BIRC3 (Baculoviral IAP repeat containing 3) • MIR192 (MicroRNA 192) • XIAP (X-Linked Inhibitor Of Apoptosis)
    |
    miR-192 expression
    |
    cisplatin
    over2years
    Alcohol Promotes Exosome Biogenesis and Release via Modulating Rabs and miR-192 Expression in Human Hepatocytes. (PubMed, Front Cell Dev Biol)
    Inhibition of miR-192 in human hepatoma cells caused a significant increase in Rab27a, Rab35, syntaxin7 and syntaxin16 and a concurrent increase in exosome secretion, suggesting miR-192 regulates exosomes release in hepatocytes. Collectively, our results reveal that alcohol modulates Rabs, VAMPs and syntaxins directly and partly via miR-192 to induce exosome machinery and release.
    Journal
    |
    RAB5A (Ras-related protein Rab-5A) • MIR192 (MicroRNA 192) • MIR122 (MicroRNA 122)
    |
    miR-192 expression
    over2years
    Nanofluorescence Probes to Detect miR-192/Integrin Alpha 1 and Their Correlations with Retinoblastoma. (PubMed, J Biomed Nanotechnol)
    After transfection, ITGA1 and miR-192 were overexpressed or silenced in RB116 cells, and we found that ITGA1 could effectively increase the activity and invasion of this RB cell line and reduce its apoptosis level, while miR-192 antagonized this tumor-promoting effect. Therefore, miR-192 can be used as an early biomarker of RB, and ITGA1 may be a new prognostic marker and therapeutic target for the treatment of RB.
    Journal
    |
    MIR192 (MicroRNA 192)
    |
    miR-192 expression
    3years
    [VIRTUAL] Diagnostic and prognostic value of miR-16, miR-146a and miR-192 in exosomes of hepatocellular and liver cirrhosis patients (EASL-ILC 2021)
    Exosomes secreted into the plasma carry differentially expressed miRNAs of which in particular, miR-192 was found as a promising prognostic maker for HCC patients while miR-146 demonstrated promising diagnostic potential to identify HCC patients in a high-risk cohort. Furthermore, expression level of miR-16 has a prognostic impact in liver cirrhosis patients.
    Clinical
    |
    AFP (Alpha-fetoprotein) • MIR192 (MicroRNA 192) • MIR221 (MicroRNA 221)
    |
    miR-192 expression
    3years
    Dysregulation of exosomal miR-192 and miR-194 expression in lung adenocarcinoma patients. (PubMed, Saudi J Biol Sci)
    However, significantly higher number of NSCLC cases showed low expression of miR-194 and miR-192 in bronchial lavage sample. Decreased poor overall survival was found to be associated with bronchial wash sample with respect to low miR-194 and miR-192 expression while NSCLC participants showed better overall survival with high miR-194 and miR-192 expression. This suggested decreased expression of miR-192 and miR-194 expression could be the potential prognostic marker among NSCLC participants.
    Clinical • Journal
    |
    MIR192 (MicroRNA 192)
    |
    miR-192 expression
    over3years
    MicroRNA-192 promotes the development of nasopharyngeal carcinoma through targeting RB1 and activating PI3K/AKT pathway. (PubMed, World J Surg Oncol)
    miR-192 promoted cell viability and metastasis in NPC through suppressing RB1 expression and activating PI3K/AKT pathway.
    Journal
    |
    RB1 (RB Transcriptional Corepressor 1) • MIR192 (MicroRNA 192)
    |
    RB1 expression • RB1 overexpression • miR-192 expression