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BIOMARKER:

miR-142 overexpression

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Other names: MIR142, MicroRNA 142, Hsa-MiR-142-3p, Hsa-MiR-142-5p, Hsa-Mir-142, MIR142, Hsa-Mir-142-V1, Hsa-Mir-142-V2, Hsa-Mir-142-V3, Hsa-Mir-142-V4, MIMAT0000433, MIMAT0000434, MI0000458, MIRN142, Mir-142, RF01896
Entrez ID:
Twitter
Trials
7ms
MicroRNAs miR-142-5p, miR-150-5p, miR-320a-3p, and miR-4433b-5p in Serum and Tissue: Potential Biomarkers in Sporadic Breast Cancer. (PubMed, Front Genet)
When combined in panels, all combinations could distinguish BC patients from controls. These results highlight a potential application of these miRNAs as BC biomarkers.
Journal
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MIR142 (MicroRNA 142) • MIR320A (MicroRNA 320a) • MIR150 (MicroRNA 150)
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miR-142 overexpression
10ms
METTL3 stabilizes HDAC5 mRNA in an mA-dependent manner to facilitate malignant proliferation of osteosarcoma cells. (PubMed, Cell Death Discov)
Xenograft tumor experiment in nude mice confirmed that METTL3 silencing repressed OS cell proliferation in vivo via the HDAC5/miR-142-5p/ARMC8 axis. Collectively, METTL3-mediated mA modification facilitated OS cell proliferation via the HDAC5/miR-142-5p/ARMC8 axis.
Journal
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HDAC5 (Histone Deacetylase 5) • MIR142 (MicroRNA 142) • METTL3 (Methyltransferase Like 3)
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miR-142 overexpression
12ms
Repressing phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma by microRNA-142-3p restrains the progression of hepatocellular carcinoma. (PubMed, Bioengineered)
PIK3CG overexpression dampened the anti-tumor effect of miR-142-3p. miR-142-3p repressed HCC invasion and intensified apoptosis to restrain HCC by abating the PIK3CG-mediated PI3K/AKT/HIF-1α pathway.
Journal
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HIF1A (Hypoxia inducible factor 1, alpha subunit) • PIK3CG (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma) • MIR142 (MicroRNA 142)
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PIK3CG expression • PIK3CG overexpression • miR-142 overexpression
12ms
Bevacizumab confers significant improvements in survival for ovarian cancer patients with low miR-25 expression and high miR-142 expression. (PubMed, J Ovarian Res)
In conclusion, miR-25 expression correlates with a better PFS and OS in ovarian cancer. Patients with low miR-25 expression and high miR-142 expression could benefit from bevacizumab treatment significantly.
Clinical • Journal
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MIR142 (MicroRNA 142) • MIR25 (MicroRNA 25)
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miR-142 overexpression • miR-25 underexpression
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Avastin (bevacizumab)
1year
miR-142-3p Regulates Tumor Cell Autophagy and Promotes Colon Cancer Progression by Targeting TP53INP2. (PubMed, Chemotherapy)
miR-142-3p hampered tumor cell autophagy and promoted CC progression via targeting TP53INP2, which will offer a fresh research orientation for the diagnosis of CC.
Journal
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MIR142 (MicroRNA 142)
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miR-142 overexpression
over1year
MicroRNA 142-5p promotes tumor growth in oral squamous cell carcinoma via the PI3K/AKT pathway by regulating PTEN. (PubMed, Heliyon)
Our results suggest that miR-142-5p is involved in the progression of OSCC by controlling the phosphatidylinositol 3-kinase (PI3K)/AKT pathway by targeting the PTEN gene. Our findings suggest that miR-142-5p may be a new target for the treatment of OSCC.
Journal
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PTEN (Phosphatase and tensin homolog) • MIR142 (MicroRNA 142)
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PTEN expression • miR-142 overexpression
over1year
Integrin αvβ3 Induces HSP90 Inhibitor Resistance via FAK Activation in KRAS-Mutant Non-Small Cell Lung Cancer. (PubMed, Cancer Res Treat)
Therefore, miR-150 and miR-142 overexpression effectively inhibited ITGAvB3-dependent FAK activation, restoring sensitivity to AUY922. The synergistic co-targeting of FAK and HSP90 attenuated the growth of ITGAvB3-induced AUY922-resistant KRAS-mutated NSCLC cells in vitro and in vivo, suggesting that this combination may overcome acquired AUY922-resistance in KRAS-mutant NSCLC.
Journal
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KRAS (KRAS proto-oncogene GTPase) • MIR142 (MicroRNA 142) • MIR150 (MicroRNA 150)
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KRAS mutation • miR-142 overexpression
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luminespib (AUY922)
over1year
Evaluation of the Oncogene Function of GOLPH3 and Correlated Regulatory Network in Lung Adenocarcinoma. (PubMed, Front Oncol)
GOLPH3 promoted LUAD progression. Moreover, TUG1 may act as ceRNA to regulate GOLPH3 expression by competitive binding miR-142-5p.
Journal • IO biomarker
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MIR142 (MicroRNA 142)
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miR-142 overexpression
over1year
miR-142-3p Modulates Cell Invasion and Migration via PKM2-Mediated Aerobic Glycolysis in Colorectal Cancer. (PubMed, Anal Cell Pathol (Amst))
In addition, we demonstrated PKM2 and PKM2-mediated aerobic glycolysis contributes to miR-142-3p-mediated colorectal cancer cell invasion and migration. Hence, these data suggested that miR-142-3p was a potential therapeutic target for the treatment of human colorectal cancer.
Journal
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MIR142 (MicroRNA 142) • PKM (Pyruvate Kinase M1/2)
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miR-142 overexpression
over1year
Regulating COX10-AS1 / miR-142-5p / PAICS axis inhibits the proliferation of non-small cell lung cancer. (PubMed, Bioengineered)
This process may be mediated by the activation of glycolysis pathway. The glycolysis-related gene PAICS may be a new and significant target for the regulation of the development of NSCLC.
Journal
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MIR142 (MicroRNA 142) • PAICS (Phosphoribosylaminoimidazole Carboxylase And Phosphoribosylaminoimidazolesuccinocarboxamide Synthase)
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miR-142 overexpression
over1year
Journal
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MIR142 (MicroRNA 142)
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miR-142 overexpression
over1year
Astragaloside IV and Saponins of Rhizoma Polygonati Cure Cyclophosphamide-Induced Myelosuppression in Lung Adenocarcinoma via Down-Regulating miR-142-3p. (PubMed, Front Oncol)
To further explore the function of AS and/or SRP in vivo, we constructed a lung cancer xenograft combined with CTX-induced myelosuppression mouse model, and we found that AS and SRP remarkably reversed the CTX-induced reduction of white blood cells, bone marrow nucleated cells, and thymus index in vivo and did not affect the chemotherapy effect of lung cancer. Collectively, our results strongly suggested that AS and SRP could improve the hematopoietic function of myelosuppressed lung cancer mice, and their effects may be related to the inhibition of miR-142-3p expression in BMHSCs.
Journal
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HMGB1 (High Mobility Group Box 1) • MIR142 (MicroRNA 142)
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miR-142 overexpression