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    BIOMARKER:

    miR-139-5p expression

    i
    Other names: MIR139, MicroRNA 139, Hsa-MiR-139-3p, Hsa-MiR-139-5p, MIMAT0004552, MIMAT0000250, Hsa-MiR-139, MiR139-3p, MI0000261, MiR-139, MiRN139, RF00703, MiR139
    Entrez ID:
    406931
    1year
    Identification and validation of an immune-related miRNA signature for predicting prognosis of hepatocellular carcinoma. (PubMed, Int Immunopharmacol)
    We further confirmed the differential expression of miR-7, miR-551a, miR-139-5p, and some of their overlapping target genes in tumor and non-tumor tissues derived from patients with HCC using RT-qPCR. Overall, we identified an immune-related miRNA signature that is strongly correlated with the prognosis and immune microenvironment of HCC; and confirmed the differential expression of the three most important microRNAs and their overlapping target genes in tumor and non-tumor tissues derived from HCC patients.
    Journal
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    MIR7 (MicroRNA 7) • MIR139 (MicroRNA 139)
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    miR-139-5p expression • miR-7 expression
    1year
    Mechanism of bone-marrow mesenchymal stem cell-derived exosomes mediating microRNA-139-5p to regulate β-catenin in the modulation of proliferation and apoptosis of acute myeloid leukemia cells. (PubMed, Hematology)
    Subsequently, up-regulated β-catenin partially counteracted the effects of miR-139-5p in BMSC-exos on AML cell proliferation and apoptosis. BMSC-exos targeted to repress β-catenin expression by miR-139-5p, limited AML cell proliferation and facilitated apoptosis.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • BAX (BCL2-associated X protein) • MIR139 (MicroRNA 139) • CD81 (CD81 Molecule) • TSG101 (Tumor Susceptibility 101)
    |
    miR-139-5p expression
    1year
    MCPIP1 modulates the miRNA‒mRNA landscape in keratinocyte carcinomas. (PubMed, J Exp Clin Cancer Res)
    Loss of MCPIP1 modulates the expression profiles of 33 miRNAs in chemically induced Mcpip1eKO papillomas, and these changes directly affect the miRNA‒mRNA network and the modulation of pathways and processes related to carcinogenesis.
    Journal
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    MIR139 (MicroRNA 139) • MIR223 (MicroRNA 223)
    |
    miR-139-5p expression
    over1year
    The novel circ_0004674/miR-139-5p/ZBTB2 regulatory cascade inhibits the development of oral squamous cell carcinoma. (PubMed, Head Neck)
    Our findings uncover a novel regulatory cascade, the circ_0004674/miR-139-5p/ZBTB2 axis, with the ability to affect OSCC development in vitro and in vivo, providing a potential opportunity for development of OSCC therapy.
    Journal
    |
    MIR139 (MicroRNA 139)
    |
    miR-139-5p expression
    over1year
    Micro-RNAs With Prognostic Significance in Gallbladder Cancer: A Systematic Review and Meta-Analysis. (PubMed, Cureus)
    In conclusion, specific miRNAs exhibit prognostic significance in GBC, with potential implications for patient stratification and targeted therapeutic interventions. However, due to the heterogeneity among studies, these findings should be interpreted cautiously and validated in larger cohorts.
    Retrospective data • Review • Journal
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    MIR7 (MicroRNA 7) • MIR139 (MicroRNA 139) • MIR141 (MicroRNA 141) • MIR335 (MicroRNA 335) • MIR92B (MicroRNA 92b) • MIR204 (MicroRNA 204) • MIR20A (MicroRNA 20a)
    |
    miR-139-5p expression
    almost2years
    GALNT2 targeted by miR-139-5p promotes proliferation of clear cell renal cell carcinoma via inhibition of LATS2 activation. (PubMed, Discov Oncol)
    Based on our experiments, miR-139-5p overexpression inhibited RCC proliferation, and this phenotype was rescued by GALNT2 overexpression. Given these evidences, the miR-139-5p-GALNT2-LATS2 axis is critical for RCC proliferation, and it is an excellent candidate for a new therapeutic target in ccRCC.
    Journal
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    LATS2 (Large Tumor Suppressor Kinase 2) • MIR139 (MicroRNA 139) • GALNT2 (Polypeptide N-Acetylgalactosaminyltransferase 2)
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    miR-139-5p expression
    almost2years
    Activation of Notch1-GATA3 pathway in asthma bronchial epithelial cells induced by acute PM2.5 exposure and the potential protective role of microRNA-139-5p. (PubMed, J Asthma)
    Acute PM2.5 exposure can activate Notch1-GATA3 pathway in asthma bronchial epithelial cells model, which might be involved in PM2.5-induced asthma exacerbation. miR-139-5p has a potential protective role of inhibiting PM2.5-induced asthma airway inflammation by targeting Notch1.
    Journal
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    NOTCH1 (Notch 1) • GATA3 (GATA binding protein 3) • MIR139 (MicroRNA 139)
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    NOTCH1 expression • miR-139-5p expression
    almost2years
    Noval ceRNA axis-mediated high expression of TOP2A correlates with poor prognosis and tumor immune infiltration of hepatocellular carcinoma. (PubMed, Transl Cancer Res)
    Additionally, TOP2A influences the development of HCC by affecting TIICs and immune checkpoints. A nomogram constructed using the three lncRNAs and clinicopathological features has good clinical utility.
    Journal
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    TOP2A (DNA topoisomerase 2-alpha) • MIR139 (MicroRNA 139)
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    miR-139-5p expression • TOP2A expression
    2years
    The Signaling Pathways Enriched in High-Risk AML Patients Revealed By the Integrative miRNA-mRNA Analysis - Pilot Study (ASH 2023)
    In FLT3 mutated pts standard induction/consolidation therapy was enriched with midostaurin. Low intensity treatment consisted of azacitidine (1 pts), low dose Ara-C (LDAra-C, 2 pts) and LDAra-C + cladribine (1 pts)...ConclusionsOur preliminary results indicate the signaling pathways disturbed in high-risk AML patients. The miR-125b-5p, miR-15a-5p as well as the TEK and SPP1 gene expression may possibly act as biomarkers in patients with de novo AML.
    Clinical
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    FLT3 (Fms-related tyrosine kinase 3) • NOTCH1 (Notch 1) • FGFR (Fibroblast Growth Factor Receptor) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • SPP1 (Secreted Phosphoprotein 1) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • MIR34A (MicroRNA 34a-5p) • MIR199B (MicroRNA 199b) • JAG1 (Jagged Canonical Notch Ligand 1) • MIR139 (MicroRNA 139) • MIR424 (MicroRNA 424) • SLIT2 (Slit Guidance Ligand 2) • MIR15A (MicroRNA 15a) • MIR181A1 (MicroRNA 181a-1) • MIR204 (MicroRNA 204) • MIR218 (MicroRNA 218) • PPIA (Peptidylprolyl Isomerase A)
    |
    FLT3 mutation • miR-139-5p expression
    |
    cytarabine • azacitidine • midostaurin • cladribine
    2years
    EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A. (PubMed, J Exp Clin Cancer Res)
    Our study revealed the role of the EZH2/miR-139-5p/TOP2A axis in regulating cellular senescence and cell proliferation in HCC, enriching the molecular mechanisms of EZH2-mediated epigenetic regulation in HCC. Therefore, our results provide insight into the therapeutic potential of targeting EZH2 to induce cellular senescence and then destroy senescent cells for HCC.
    Journal
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    EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit) • TOP2A (DNA topoisomerase 2-alpha) • MIR139 (MicroRNA 139)
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    TOP2A overexpression • EZH2 overexpression • miR-139-5p expression • TOP2A expression
    2years
    VALIDATION AND ASSESSMENT FEASIBILITY OF HSA‐MIR‐139‐5P EXPRESSION AS A PROGNOSTIC MARKER IN THYROID CANCER (ATA 2023)
    Our results confirm the value of miR139‐expression as a prognostic marker in thyroid cancer and underscores the clinical utility of in situ miR139‐expression assessment in diagnostic biopsies.
    TERT (Telomerase Reverse Transcriptase) • MIR139 (MicroRNA 139)
    |
    TERT mutation • KIT expression • TERT promoter mutation • miR-139-5p expression
    over2years
    MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2. (PubMed, Pathol Res Pract)
    MiR-139-5p was a tumor suppressor in NSCLC by regulating the oncogene ATAD2 and β-catenin signaling. Our study provides a promising target for cancer treatment.
    Journal
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    MIR139 (MicroRNA 139) • ATAD2 (ATPase Family AAA Domain Containing 2)
    |
    miR-139-5p expression