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    BIOMARKER:

    miR-1287 expression

    i
    Other names: MIR1287, MicroRNA 1287, Hsa-Mir-1287, Hsa-MiR-1287-5p, MIR1287, MIMAT0026738, MIMAT0005878, MI0006349, MIRN1287, Mir-1287, RF02015
    Entrez ID:
    100302133
    Related biomarkers:
    Expression
    over2years
    miR-4796 enhances the sensitivity of breast cancer cells to ionising radiation by impairing the DNA repair pathway. (PubMed, Breast Cancer)
    The findings here suggest that miR-4796 can enhance radiation-induced cell death by directly targeting multiple DDR components, and repress NHEJ and HR DNA repair pathways. miR-4796 can act as an effective radiation sensitising agent.
    Review • Journal • BRCA Biomarker • PARP Biomarker
    |
    BRCA1 (Breast cancer 1, early onset) • RAD51 (RAD51 Homolog A) • PARP1 (Poly(ADP-Ribose) Polymerase 1)
    |
    ATM overexpression • RAD51 overexpression • ATM expression • miR-128 expression • miR-1287 expression
    over2years
    Downregulation of circ_PLXND1 inhibits tumorigenesis of non-small cell lung carcinoma via miR-1287-5p/ERBB3 axis. (PubMed, Thorac Cancer)
    Circ_PLXND1 knockdown impeded NSCLC progression through modulating the miR-1287-5p/ERBB3 axis, indicating a promising molecular target for NSCLC treatment.
    Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3)
    |
    ERBB3 expression • miR-128 expression • miR-1287 expression
    almost4years
    MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4. (PubMed, Free Radic Res)
    Moreover, the miR-1287-5p mimic dramatically sensitized human osteosarcoma cells to cisplatin chemotherapy. Our findings prove that miR-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4, identifying an adjuvant and even alternative method for the treatment of human osteosarcoma.
    Journal
    |
    GPX4 (Glutathione Peroxidase 4)
    |
    GPX4 expression • GPX4 overexpression • miR-128 expression • miR-1287 expression
    |
    cisplatin
    over4years
    miR-1287-5p upregulation inhibits the EMT and pro-inflammatory cytokines in LPS-induced human nasal epithelial cells (HNECs). (PubMed, Transpl Immunol)
    miR-1287-5p downregulation was associated with chronic rhinosinusitis and its upregulation inhibited the EMT and inflammation in LPS-induced HNECs through Snai1/HMGB1 pathway.
    Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CDH1 (Cadherin 1) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • HMGB1 (High Mobility Group Box 1) • VIM (Vimentin)
    |
    miR-128 expression • miR-1287 expression
    over5years
    CircRNA CDR1as/miR-1287/Raf1 Axis Modulates Hepatocellular Carcinoma Progression Through MEK/ERK Pathway. (PubMed, Cancer Manag Res)
    In addition, circ_CDR1as depletion suppresses tumor growth in vivo via regulating miR-1287/Raf1 pathway. Circ_CDR1as depletion inhibits HCC cell proliferation and metastasis by miR-1287/Raf1 and MEK/ERK pathways, highlighting a promising molecular target for HCC treatment.
    Journal
    |
    RAF1 (Raf-1 Proto-Oncogene Serine/Threonine Kinase)
    |
    miR-1287 expression