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    BIOMARKER:

    miR-1244 expression

    i
    Other names: MIR1244-1, MicroRNA 1244-1, MicroRNA 1244, Hsa-Mir-1244, Hsa-Mir-1244-1, MIR1244-2, MIR1244-3, MIR1244-4, MIRN1244, MIR1244
    Entrez ID:
    100302285
    Related biomarkers:
    Expression
    1year
    The Yin and Yang of hsa-miR-1244 expression levels during activation of the UPR control cell fate. (PubMed, Cell Commun Signal)
    This is the first example of a complex mechanism by which this miRNA serves as a regulatory check point for all 3 pathways that is switched off during UPR activation. In summary, the results indicate that ER stress reduction of miR-1244 expression contributes to the pro-survival arm of UPR.
    Journal
    |
    HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • ATF6 (Activating Transcription Factor 6) • ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1)
    |
    miR-1244 expression
    over3years
    Circ_0136666 aggravates osteosarcoma development through mediating miR-1244/CEP55 axis. (PubMed, J Orthop Surg Res)
    Circ_0136666 silencing inhibited OS progression partly by targeting miR-1244/CEP55 signaling. Silencing circ_0136666 and CEP55 or restoring miR-1244 level might be a potential therapeutic strategy for OS.
    Journal
    |
    CEP55 (Centrosomal Protein 55)
    |
    miR-1244 expression • miR-1244 overexpression