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    BIOMARKER:

    miR-10a-5p overexpression

    i
    Other names: MIR10A, MicroRNA 10a, Hsa-Mir-10a, Hsa-MiR-10a-3p, Hsa-MiR-10a-5p, MIRN10A, Hsa-Mir-10-P1a-V1, Hsa-Mir-10-P1a-V2, MIMAT0000253, MIMAT0004555, MI0000266, MiRNA10A, Mir-10a, RF00104
    Entrez ID:
    406902
    almost3years
    lncRNA TUSC7 sponges miR-10a-5p and inhibits BDNF/ERK pathway to suppress glioma cell proliferation and migration. (PubMed, Aging (Albany NY))
    TUSC7 suppresses human glioma cell proliferation and migration by negatively modulating miR-10a-5p and inhibiting the BDNF/ERK pathway, thus acting as a tumor suppressor gene in human gliomas.
    Journal
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    TUSC7 (Tumor Suppressor Candidate 7) • BDNF (Brain Derived Neurotrophic Factor)
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    TUSC7 overexpression • miR-10a-5p overexpression
    3years
    Upregulation of miRNA-10a-5p promotes tumor progression in cervical cancer by suppressing UBE2I signaling. (PubMed, J Obstet Gynaecol)
    These findings provide mechanistic insights into how miR-10a-5p regulates cervical cancer hyper-proliferation and metastasis, as well as a new target for clinical treatment. Nevertheless, whether miR-10a-5p/UBE2I axis can be regulated by non-invasive methods need further exploration, which will be the focus of our future research.
    Journal
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    UBE2I (Ubiquitin Conjugating Enzyme E2 I)
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    miR-10a-5p overexpression
    over3years
    Lnc-SELPLG-2:1 enhanced osteosarcoma oncogenesis via hsa-miR-10a-5p and the BTRC cascade. (PubMed, BMC Cancer)
    Lnc-SELPLG-2:1 is an oncogenesis activator in osteosarcoma, and its functions are performed via hsa-miR-10a-5p /BTRC cascade.
    Journal
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    MMP2 (Matrix metallopeptidase 2) • VIM (Vimentin) • MMP9 (Matrix metallopeptidase 9)
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    VIM expression • miR-10a-5p overexpression
    almost4years
    microRNA-10a-5p from gastric cancer cell-derived exosomes enhances viability and migration of human umbilical vein endothelial cells by targeting zinc finger MYND-type containing 11. (PubMed, Bioengineered)
    Notably, miR-10a-5p mimic-modified HGC-27 exo enhanced the viability, migration and tube formation ability of HUVECs, but this effect was impaired after up-regulating ZMYND11. In summary, miR-10a-5p from GC cells-derived exo enhances viability and migration of HUVECs by suppressing ZMYND11.
    Journal
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    MIR10A (MicroRNA 10a) • SMYD3 (SET And MYND Domain Containing 3)
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    SMYD3 overexpression • miR-10a-5p overexpression