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    BIOMARKER:

    miR-100-5p overexpression

    i
    Other names: MIR100, MicroRNA 100, Hsa-MiR-100-3p, Hsa-MiR-100-5p, Hsa-Mir-100, MIR100, Hsa-Mir-10-P2a, MIRN100, MiR-100
    Entrez ID:
    406892
    Related biomarkers:
    Expression
    over1year
    Dual epigenetic changes in diabetes mellitus-associated pancreatic ductal adenocarcinoma correlate with downregulation of E-cadherin and worsened prognosis. (PubMed, J Pathol Clin Res)
    OS and DFS worsened in DM subjects with both HbA1c ≥ 6.5% and DM duration ≥3 years. Thus, DM is associated with two modes of epigenetic change by independent mechanisms and worsens prognosis.
    Journal
    |
    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CDH1 (Cadherin 1) • MIR100 (MicroRNA 100)
    |
    CDH1 expression • miR-100 expression • miR-100-5p overexpression
    over2years
    Overexpression of miR-100-5p inhibits papillary thyroid cancer progression via targeting FZD8. (PubMed, Open Med (Wars))
    Moreover, in the collected samples, miR-100-5p was lowly expressed in PTC tissues compared with normal tissues, especially in those of advanced stage (Stage III/IV vs Stage I/II), while FZD8 was highly expressed in PTC tissues, which in PTC tissues was inversely correlated to miR-100-5p. Thus, we suggest that overexpression of miR-100-5p inhibits the development of PTC by targeting FZD8.
    Journal
    |
    MIR100 (MicroRNA 100)
    |
    miR-100 expression • miR-100-5p overexpression
    almost3years
    Role of miR-100-5p and CDC25A in breast carcinoma cells. (PubMed, PeerJ)
    Together, these findings unveiled that CDC25A may be a key target of miR-100-5p that mediated progression of BC cells. Hence, miR-100-5p overexpression or CDC25A suppression may contribute to BC diagnosis.
    Journal
    |
    MIR100 (MicroRNA 100) • CDC25A (Cell Division Cycle 25A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    |
    miR-100-5p overexpression