minocycline

P4, N=42, Not yet recruiting, Stony Brook University

P2, N=15, Recruiting, Radboud University Medical Center | Trial completion date: Sep 2024 --> Dec 2025 | Trial primary completion date: Aug 2024 --> Aug 2025

P1, N=60, Not yet recruiting, Ruijin Hospital

Clinically used drugs deferiprone and minocycline reduced mitochondrial iron and superoxide levels, resulting in decreased colon tumor cell growth in vitro and in vivo. Manipulating the mitochondrial iron uptake protein MCU (mitochondrial calcium uniporter) also affected cell and xenograft tumor growth. This study suggests that therapies aimed at reducing mitochondrial iron levels may effectively inhibit colon tumor growth, particularly in patients with low PINK1 expression.

In mice with pancreatic cancer-induced pain, the microglia activation in the NTS was observed, characterized by increased cell density and decreased process number and length, while injection of microglia inhibitor minocycline in the NTS alleviated pancreatic cancer-induced pain...Blocking CXCL1-CXCR2 signaling by injection of CXCL1 neutralizing antibody or CXCR2 antagonist SB225002 in the NTS of mice with pancreatic cancer-induced pain alleviated abdominal hypersensitivity and hunching behavior, and also reversed the activation of neurons and microglia. Additionally, injection of recombinant CXCL1 in the NTS of sham-operated mice induced abdominal pain, and activated the neurons and microglia. In summary, our study highlights the critical role of NTS microglia activation mediated by CXCL1-CXCR2 signaling in pancreatic cancer-induced pain.

P4, N=574, Not yet recruiting, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Tongji Hospital, Tongji Medical College, Huazhong University o

P4, N=600, Recruiting, West China Hospital of Sichuan University; West China Hospital of Sichuan University

This indicates that ciprofloxacin enhances autophagy, increasing the amount of free Beclin-1 via phosphorylated Bcl-2, and inhibits caspase activity. Therefore, ciprofloxacin might protect against renal tubular injury through the activation of autophagy in the setting of acute kidney injury.

P2, N=200, Recruiting, Janssen Research & Development, LLC | N=300 --> 200

P4, N=548, Recruiting, Xijing Hospital of Digestive Diseases

P3, N=400, Recruiting, University of Nebraska | Trial primary completion date: Mar 2026 --> Mar 2027

P1, N=172, Not yet recruiting, Peking University First Hospital; Peking University First Hospital

Inhibition of microglia by pretreatment with minocycline or depletion of microglia by PLX3397 abolished the preventive effect of low-dose LPS pre-injection on mSPS-induced anxiety- and fear-like behavior and neuroinflammatory responses. These results suggest that pre-stimulation of microglia may prevent the development of PTSD-like behaviors by attenuating the development of neuroinflammatory responses. This could help to develop new strategies to prevent the damaging effects of harmful stress on the brain.

Age <65 years and anemia were identified as independent baseline risk factors. Additionally, combination prophylaxis was found to be a preventive factor against anti-EGFR monoclonal antibody-induced grade ≥2 overall skin toxicities in patients with liver metastatic CRC.

P4, N=200, Recruiting, Shanghai Jiao Tong University School of Medicine

P4, N=476, Recruiting, Shanghai Jiao Tong University School of Medicine

Despite attenuation of IL-8, minocycline did not alter self-reported affective symptoms or cognition in this cohort of BC survivors undergoing chemotherapy. The effect of minocycline on BC survivors symptomatic for depression before chemotherapy warrants further investigation.

P1, N=24, Recruiting, Northwell Health | Trial completion date: Jun 2024 --> Sep 2025 | Trial primary completion date: Jun 2024 --> Sep 2024

P=N/A, N=35, Not yet recruiting, King's College London

P4, N=208, Not yet recruiting, Xijing Hospital of Digestive Diseases

The results of our study showed that blocking microglial activation via CSF1R may help prevent cancer-induced orofacial pain.

P4, N=120, Not yet recruiting, University of Florida | Initiation date: Apr 2024 --> Oct 2024

P2, N=672, Enrolling by invitation, University of California, San Francisco | Not yet recruiting --> Enrolling by invitation

The second experiment involved in 56 rats, through central anti-inflammation by feeding with 10 mg/ml minocycline sucrose solution as the only water source, or right vagus transection excepting for central anti-inflammation as a mean of the CAP's functional cancel, we confirmed that the neuroinflammation in MVZ affected systemic inflammation through CAP in sepsis...However, right vagotomy abolished the central anti-inflammatory effect. Our study uncovered that MVZ's neuroinflammation may play a crucial role in the uncontrolled systemic inflammation through inflammatory demyelination in MVZ, which disrupts CAP's modulation on the systemic inflammation in early sepsis.

Locally suppressing dCA1 M1-like microglia activation with minocycline administration attenuated A1-like polarization of astrocytes, ameliorated dCA1 neurotoxicity, and, most importantly, rescued spatial memory in methamphetamine abstinence mice. The effective time window of minocycline treatment on spatial memory is the methamphetamine exposure period, rather than the long-term methamphetamine abstinence.

P=N/A, N=823, Completed, Shanghai Jiao Tong University School of Medicine | Recruiting --> Completed | N=600 --> 823 | Trial completion date: Jun 2034 --> Apr 2024 | Initiation date: Oct 2021 --> Mar 2021

P2, N=672, Not yet recruiting, University of California, San Francisco | Trial completion date: Feb 2029 --> Aug 2029 | Trial primary completion date: Feb 2028 --> Aug 2028

P4, N=51, Completed, Beijing Stomatological Hospital, Capital Medical University | Not yet recruiting --> Completed

P2, N=300, Recruiting, Janssen Research & Development, LLC | N=180 --> 300

These findings further confirmed the anticancer effect of minocycline and highlighted that minocycline maybe considered as potential therapeutic agent for breast cancer treatment.

P=N/A, N=600, Recruiting, Shanghai Jiao Tong University School of Medicine

The effect of microglial polarization on the regulation of spinal necroptosis was elucidated by administering minocycline to inhibit PTX-induced M1 polarization of spinal microglia caused by PTX. Overall, this study suggests that PTX-induced polarization of spinal microglia leads to RIP3/MLKL-regulated necroptosis, resulting in PIPN. These findings suggest a potential target for the prevention and treatment of neuropathic pain.

P2, N=180, Recruiting, Janssen Research & Development, LLC | Not yet recruiting --> Recruiting

P1/2, N=0, Withdrawn, University of Florida | N=56 --> 0 | Not yet recruiting --> Withdrawn

P4, N=120, Not yet recruiting, University of Florida

P2/3, N=30, Not yet recruiting, Ain Shams University

P2, N=37, Completed, National Eye Institute (NEI) | Active, not recruiting --> Completed

P2, N=46, Recruiting, Mostafa Bahaa | Not yet recruiting --> Recruiting

Microglia-mediated GABAergic synapse pruning in the spinal cord dorsal horn in bone cancer pain mice, which might be associated with the declined CD47-SIRPα signal. Our research uncovered an innovative mechanism that highlighted microglia-mediated synaptic phagocytosis in a murine cancer-induced bone pain model.

P2, N=60, Recruiting, IRCCS Centro San Giovanni di Dio Fatebenefratelli

P2, N=46, Not yet recruiting, Mostafa Bahaa

The administration of minocycline hydrochloride and metronidazole in patients with localized periodontitis undergoing implantation can reduce oral inflammatory response, reduce postoperative infection and other complications, and improve periodontal health.