minocycline

P4, N=544, Not yet recruiting, Shanghai Zhongshan Hospital

P4, N=290, Not yet recruiting, Shanghai Zhongshan Hospital

When animals were challenged with TNFα after receiving minocycline, fewer c-Fos-positive cells were induced in the DVC and selectively in the rostral VLM. These findings highlight the spatial selectivity of cells in the brainstem to increased peripheral pro-inflammatory signaling, as well as the impact of resident microglia on autonomic circuitry responses.

Inhibition of MG/Mϕ with long-term minocycline treatment attenuated the incidence of ICHs around bAVMs. Our study indicates that MG/Mϕ are involved in destabilization of KRAS-induced bAVM, leading to hemorrhagic conversion/ICH. Thus, modulation of MG/Mϕ may reduce ICH risk in bAVM patients.

P=N/A, N=60, Not yet recruiting, Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University; Provincial People's Hospital (Guangdong Academy of

P=N/A, N=340, Not yet recruiting, Northern Jiangsu People's Hospital; Northern Jiangsu People's Hospital

P=N/A, N=30, Completed, Peking University First Hospital; Peking University First Hospital

P=N/A, N=1248, Not yet recruiting, The First Hospital of Jilin University; The First Hospital of Jilin University

P4, N=1192, Not yet recruiting, Beijing Tiantan Hospital, Capital Medical University; Beijing Tiantan Hospital, Capital Medical University

P4, N=75, Not yet recruiting, The First Affiliated Hospital of Army Medical University; The First Affiliated Hospital of Army Medical University

P=N/A, N=316, Recruiting, Sir Run Run Hospital, Nanjing Medical University; Sir Run Run Hospital, Nanjing Medical University | Not yet recruiting --> Recruiting

Minocycline administration significantly mitigates mechanical allodynia and modulates hippocampal neuroinflammatory markers in a rat model of neuropathic pain. These results highlight minocycline's potential as a therapeutic option for neuropathic pain, particularly in targeting neuroinflammation within the hippocampus.