minocycline

P=N/A, N=340, Not yet recruiting, Northern Jiangsu People's Hospital; Northern Jiangsu People's Hospital

P=N/A, N=60, Not yet recruiting, Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University; Provincial People's Hospital (Guangdong Academy of

P=N/A, N=30, Completed, Peking University First Hospital; Peking University First Hospital

P=N/A, N=1248, Not yet recruiting, The First Hospital of Jilin University; The First Hospital of Jilin University

P4, N=1192, Not yet recruiting, Beijing Tiantan Hospital, Capital Medical University; Beijing Tiantan Hospital, Capital Medical University

P4, N=75, Not yet recruiting, The First Affiliated Hospital of Army Medical University; The First Affiliated Hospital of Army Medical University

P=N/A, N=316, Recruiting, Sir Run Run Hospital, Nanjing Medical University; Sir Run Run Hospital, Nanjing Medical University | Not yet recruiting --> Recruiting

Minocycline administration significantly mitigates mechanical allodynia and modulates hippocampal neuroinflammatory markers in a rat model of neuropathic pain. These results highlight minocycline's potential as a therapeutic option for neuropathic pain, particularly in targeting neuroinflammation within the hippocampus.

P3, N=1192, Not yet recruiting, Beijing Tiantan Hospital

P=N/A, N=210, Active, not recruiting, Psychiatric University Hospital, Zurich | Recruiting --> Active, not recruiting

P1, N=50, Completed, First Affiliated Hospital of Chongqing Medical University | Trial completion date: Jan 2025 --> Jul 2025 | Trial primary completion date: Dec 2024 --> Jul 2025

Oral tetracyclines appear to reduce the incidence of all-grade acneiform rash or, alternatively, to decrease the incidence of high-grade rash. Preventive treatment for acneiform rash at the initiation of epidermal growth factor receptor tyrosine kinase inhibitor therapy should therefore be considered. Further controlled trials are needed to confirm the efficacy of oral tetracyclines in preventing acneiform rash.