minocycline

Compared with minocycline hydrochloride alone, the addition of tinidazole further improved patients' periodontal health, reduced the inflammatory response and MMP-9, SIgA levels, and did not increase the risk of adverse reactions. This suggests good drug safety and clinical promotion value.

P1/2, N=23, Recruiting, TenNor Therapeutics Inc. | Not yet recruiting --> Recruiting

P2, N=201, Active, not recruiting, Janssen Research & Development, LLC | N=300 --> 201 | Recruiting --> Active, not recruiting

P=N/A, N=345, Not yet recruiting, Lanzhou University Second Hospital; Lanzhou University Second Hospital

P4, N=238, Recruiting, Army Medical Center of PLA; Army Medical Center of PLA

P4, N=260, Not yet recruiting, Lanzhou University Second Hospital; Lanzhou University Second Hospital

P=N/A, N=5000, Not yet recruiting, Fujian Medical University; Fujian Medical University

P=N/A, N=300, Not yet recruiting, Fujian Provincial Hospital; Fujian Provincial Hospital

P=N/A, N=140, Not yet recruiting, Peking University Third Hospital; Peking University Third Hospital

P2, N=300, Recruiting, Janssen Research & Development, LLC | N=200 --> 300

P1/2, N=23, Not yet recruiting, TenNor Therapeutics Inc.

Finally, molecular docking results showed B-cell CLL/lymphoma 2 (BCL2-6), CTNNB1, HSP90AA1, plasminogen activator urokinase (PLAU), and α protein kinase C alpha (PRCAKA) bound to minocycline better. This article concluded that minocycline was effective in treating SCI by improving neurological recovery and inhibiting oxidative stress, apoptosis, and inflammation.

P2, N=40, Recruiting, Xijing Hospital | Trial completion date: Dec 2028 --> Apr 2025 | Trial primary completion date: May 2028 --> Jan 2025

P2, N=200, Recruiting, Janssen Research & Development, LLC | Active, not recruiting --> Recruiting

P2, N=201, Active, not recruiting, Janssen Research & Development, LLC | Recruiting --> Active, not recruiting

Adult male mice were treated with the chemotherapeutic drugs 5-fluorouracil and leucovorin (5-Fu/LV, intraperitoneal injection, I.P.) on Days 1, 8, and 15 at a dosage of 50 mg/kg for 5-Fu and 90 mg/kg for LV for 3 weeks...Furthermore, 5-Fu/LV treatment reduced the long-term potentiation (LTP) recorded in the hippocampal CA1 region in response to a theta burst stimulation of the CA3-CA1 pathway and decreased the evoked N-methyl-D-aspartic acid receptor (NMDAR)-excitatory postsynaptic currents (NMDAR-EPSCs) in CA1 neurons. Cotreatment with the microglial inhibitor minocycline (33 mg/kg, daily for 3 weeks) restored cognitive deficits and microglial ramification, decreased the number of CD68-positive microglia, and reversed the reductions in LTP and the amplitude of NMDAR-EPSCs in 5-Fu/LV-treated mice. Our data suggest that microglial dysfunction and related synaptic dysfunction contribute to 5-Fu/LV-induced cognitive impairment.

P2, N=200, Recruiting, Janssen Research & Development, LLC | Trial primary completion date: Jul 2025 --> Nov 2025

P4, N=58, Completed, Inonu University

The conditioned medium from sevoflurane-treated microglia inhibited the OPC proliferation and differentiation, while minocycline or PLX5622 alleviated sevoflurane-induced neuroinflammation and hypomyelination. Therefore, repeated sevoflurane exposure negatively affected OPC differentiation and myelination trajectory through hyperactivating microglia in developing brain, leading to motor and cognitive impairments, while microglial inhibition/depletion could protect against sevoflurane-induced damage on developing myelination.

Therapies for ENL management, such as thalidomide, methotrexate, apremilast, minocycline and tumour necrosis factor-alpha inhibitors, hold potential. This review addresses recent advances in leprosy reaction pathogenesis and diagnostics, offering therapeutic insights and preventive strategies to mitigate their onset.

We evaluated whether higher plasma interleukin 6 (IL-6) levels would be associated with more severe negative or depressive symptoms in schizophrenia and explored illness stage utilizing early (BeneMin [Benefit of Minocycline on Negative Symptoms of Psychosis: Extent and Mechanism], n = 201, 72.8% male) and established (iRELATE [Immune Response & Social Cognition in Schizophrenia], n = 94, 67.3% male) schizophrenia cohorts...All analyses were adjusted for sex, age, and chlorpromazine equivalent dose...Our results indicate that higher plasma IL-6 levels may be differently associated with the severity of depressive and negative symptoms dependent on the illness stage. Future work identifying elevated levels of inflammation in larger samples may allow stratification and personalized intervention by subgroups who are at risk of poor outcomes.

P=N/A, N=56, Peking University Stomatological Hospital; Sunstar Co.Ltd

P1, N=284, Fujian Provincial Hospital; Fujian Provincial Hospital

P1, N=50, Completed, First Affiliated Hospital of Chongqing Medical University

P2, N=56, Completed, Ohio State University Comprehensive Cancer Center | Active, not recruiting --> Completed

P1, N=60, Recruiting, Ruijin Hospital | Not yet recruiting --> Recruiting

Moreover, it was found that the TLR4/MyD88/NF-κB pathway was involved in the shift of microglia from a pro-inflammatory (M1) to an anti-inflammatory (M2). In summary, minocycline likely mediated the process of microglia polarization partly via the TLR4/MyD88/NF-κB pathway, promoting neuronal survival and restoring synaptic plasticity, thereby improving TN-related cognitive impairment.

P4, N=120, Recruiting, University of Florida | Not yet recruiting --> Recruiting

P1, N=30, Not yet recruiting, University of Cincinnati | Trial completion date: Jun 2026 --> Dec 2026 | Trial primary completion date: Dec 2025 --> May 2026

P4, N=42, Not yet recruiting, Stony Brook University

P2, N=15, Recruiting, Radboud University Medical Center | Trial completion date: Sep 2024 --> Dec 2025 | Trial primary completion date: Aug 2024 --> Aug 2025

P1, N=60, Not yet recruiting, Ruijin Hospital

Clinically used drugs deferiprone and minocycline reduced mitochondrial iron and superoxide levels, resulting in decreased colon tumor cell growth in vitro and in vivo. Manipulating the mitochondrial iron uptake protein MCU (mitochondrial calcium uniporter) also affected cell and xenograft tumor growth. This study suggests that therapies aimed at reducing mitochondrial iron levels may effectively inhibit colon tumor growth, particularly in patients with low PINK1 expression.

In mice with pancreatic cancer-induced pain, the microglia activation in the NTS was observed, characterized by increased cell density and decreased process number and length, while injection of microglia inhibitor minocycline in the NTS alleviated pancreatic cancer-induced pain...Blocking CXCL1-CXCR2 signaling by injection of CXCL1 neutralizing antibody or CXCR2 antagonist SB225002 in the NTS of mice with pancreatic cancer-induced pain alleviated abdominal hypersensitivity and hunching behavior, and also reversed the activation of neurons and microglia. Additionally, injection of recombinant CXCL1 in the NTS of sham-operated mice induced abdominal pain, and activated the neurons and microglia. In summary, our study highlights the critical role of NTS microglia activation mediated by CXCL1-CXCR2 signaling in pancreatic cancer-induced pain.

P4, N=600, Recruiting, West China Hospital of Sichuan University; West China Hospital of Sichuan University

P4, N=574, Not yet recruiting, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Tongji Hospital, Tongji Medical College, Huazhong University o

This indicates that ciprofloxacin enhances autophagy, increasing the amount of free Beclin-1 via phosphorylated Bcl-2, and inhibits caspase activity. Therefore, ciprofloxacin might protect against renal tubular injury through the activation of autophagy in the setting of acute kidney injury.

P2, N=200, Recruiting, Janssen Research & Development, LLC | N=300 --> 200

P4, N=548, Recruiting, Xijing Hospital of Digestive Diseases

P3, N=400, Recruiting, University of Nebraska | Trial primary completion date: Mar 2026 --> Mar 2027

P1, N=172, Not yet recruiting, Peking University First Hospital; Peking University First Hospital

Inhibition of microglia by pretreatment with minocycline or depletion of microglia by PLX3397 abolished the preventive effect of low-dose LPS pre-injection on mSPS-induced anxiety- and fear-like behavior and neuroinflammatory responses. These results suggest that pre-stimulation of microglia may prevent the development of PTSD-like behaviors by attenuating the development of neuroinflammatory responses. This could help to develop new strategies to prevent the damaging effects of harmful stress on the brain.