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    DRUG:

    midazolam hydrochloride

    Associations

    News

    Trials
    Company:
    Generic mfg.
    Drug class:
    GABA A receptor agonist
    Associations

    News

    Trials
    2d
    Attenuate the Stress Response in Laparoscopic Cholecystectomy (clinicaltrials.gov)
    P4, N=50, Not yet recruiting, Assiut University
    New P4 trial
    |
    midazolam hydrochloride
    2d
    A First-in-human Trial of GRT7041 in Healthy Participants (clinicaltrials.gov)
    P1, N=70, Recruiting, Grünenthal GmbH | Not yet recruiting --> Recruiting
    Enrollment open • First-in-human
    |
    midazolam hydrochloride
    5d
    A Study to Test How Well Different Doses of BI 3031185 Are Tolerated by Healthy Men (clinicaltrials.gov)
    P1, N=60, Recruiting, Boehringer Ingelheim | Trial completion date: Jul 2026 --> Nov 2026 | Trial primary completion date: Jul 2026 --> Nov 2026
    Trial completion date • Trial primary completion date
    |
    midazolam hydrochloride
    5d
    Dexmedetomidine vs Midazolam in Coronary Artery By-pass Surgery (clinicaltrials.gov)
    P=N/A, N=60, Recruiting, Cumhuriyet University
    New trial
    |
    midazolam hydrochloride
    7d
    Remimazolam Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Macrophages. (PubMed, Bull Tokyo Dent Coll)
    Although benzodiazepines, including midazolam, possess anti-inflammatory properties and suppress macrophage activity, the impact of Re on macrophage-mediated immune responses remains uncertain. Conversely, Re did not affect the phagocytic capacity of TGC-macrophages, as evaluated by fluorescein isothiocyanate-labeled dextran, even at concentrations that inhibited inflammatory cytokine production and costimulatory molecule expression in LPS-activated TGC-macrophages. These findings suggest that Re exerts anti-inflammatory effects without suppressing essential innate immune functions, such as phagocytosis by macrophages.
    Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) • CD86 (CD86 Molecule)
    |
    midazolam hydrochloride
    9d
    Adverse Cardiovascular Events During Painless Gastroscopy Diagnosis and Treatment in Elderly Frail Patients (clinicaltrials.gov)
    P=N/A, N=226, Recruiting, Beijing Friendship Hospital | Completed --> Recruiting | N=108 --> 226 | Trial completion date: Feb 2024 --> Feb 2026 | Trial primary completion date: Feb 2024 --> Feb 2026
    Enrollment open • Enrollment change • Trial completion date • Trial primary completion date • Adverse events
    |
    midazolam hydrochloride
    12d
    ISOREA: Comparison of Extubation Delay After Prolonged Sedation (clinicaltrials.gov)
    P4, N=1, Terminated, University Hospital, Rouen | N=59 --> 1 | Recruiting --> Terminated; COVID epidemic and sedation practices that have completely changed: the standard sedative is now propofol rather than midazolam.
    Enrollment change • Trial termination
    |
    midazolam hydrochloride
    12d
    DEXPRE: Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants (clinicaltrials.gov)
    P3, N=380, Recruiting, Assistance Publique - Hôpitaux de Paris | Not yet recruiting --> Recruiting
    Enrollment open
    |
    midazolam hydrochloride
    13d
    Drug Interaction Study of ZYN002 Transdermal Gel and Probe Substrates (clinicaltrials.gov)
    P1, N=29, Completed, Harmony Biosciences Management, Inc. | Recruiting --> Completed
    Trial completion
    |
    midazolam hydrochloride
    17d
    A Phase 1 Drug-Drug Interaction Study to Assess the Interaction Potential of NB-4746 on CYP1A2 and CYP3A4 Substrates and Characterize the Pharmacokinetic Profiles of NB-4746 Capsules in Healthy Volunteers (ACTRN12624001072505)
    P1, N=68, Completed, Nura Bio | Not yet recruiting --> Completed | N=18 --> 68
    Trial completion • Enrollment change
    |
    CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4)
    |
    midazolam hydrochloride
    17d
    A Study of Elenestinib in Healthy Adult Female Participants (clinicaltrials.gov)
    P1, N=20, Recruiting, Blueprint Medicines Corporation
    New P1 trial
    |
    elenestinib (BLU-263) • midazolam hydrochloride
    18d
    The Effectiveness of Binaural Beats on Midazolam Requirement During Cesarean Section With Spinal Anesthesia (clinicaltrials.gov)
    P=N/A, N=100, Not yet recruiting, Yonsei University
    New trial
    |
    midazolam hydrochloride