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    GENE:

    MIR30C

    i
    Other names: MicroRNA 30c, MIR30C
    Associations

    News

    Trials
    3ms
    Intracranial self-stimulation mitigates spatial task deficits, modifies miR-146a and miR-495 serum levels and restores hippocampal NRF2 levels in a rat model of sporadic Alzheimer's disease. (PubMed, Front Aging Neurosci)
    These findings highlight the therapeutic potential of MFB-ICSS as a non-pharmacological intervention in AD. Furthermore, this study confirms NRF2 as a target of miR-495 in the context of AD.
    Preclinical • Journal
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    MIR16 (MicroRNA 16) • MIR495 (MicroRNA 495) • MIR191 (MicroRNA 191) • MIR30C
    3ms
    MicroRNA Signatures in Serous Ovarian Cancer: A Comparison of Prognostic Marker Targets in African Americans and Caucasians. (PubMed, Diseases)
    Pathway enrichment and gene ontology analyses (miRTargetLink2.0, Enrichr) revealed interconnected regulatory networks linking miR-192, miR-16-5p, miR-143-3p, and miR-20a-5p to ITGB1; miR-143-3p/miR-145-5p to BRAF; and miR-16-5p and miR-30c/d to TIMP3. Collectively, these findings identify distinct miRNA-mRNA regulatory signatures-particularly the miR-192-5p-ITGB1/TIMP3 axis-as potential clinically relevant biomarkers that may contribute to racial disparities and disease progression in ovarian cancer.
    Journal
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    BRAF (B-raf proto-oncogene) • MIR192 (MicroRNA 192) • MIR143 (MicroRNA 143) • MIR16 (MicroRNA 16) • MIR30D (MicroRNA 30d) • ITGB1 (Integrin Subunit Beta 1) • MIR145 (MicroRNA 145) • MIR20A (MicroRNA 20a) • MIR30C • TIMP3 (TIMP Metallopeptidase Inhibitor 3)
    4ms
    Renal cell carcinoma detection: a systematic review in diagnostic urinary biomarkers. (PubMed, BMC Cancer)
    Various urinary biomarkers for RCC show promising diagnostic potential. The diagnostic ability of multi-biomarker panels often exceeded those of individual markers. However, individual markers and panels require external validation before clinical implementation.
    Review • Journal
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    AQP1 (Aquaporin 1) • PLIN2 (Perilipin) • MIR122 (MicroRNA 122) • MIR15A (MicroRNA 15a) • MIR30C
    4ms
    MicroRNA Deregulation and Immune Checkpoint Interactions in Common Variable Immunodeficiency and CLL-Associated Secondary Immunodeficiency. (PubMed, Cells)
    Correlations between miRNA levels and the expression of immune checkpoints (PD-1, CTLA-4, CD200) indicated the involvement of a complex regulatory network encompassing both humoral and cellular immune mechanisms. The results provide preliminary evidence that selected miRNAs could reflect disease-specific immune dysregulation patterns and may hold potential as diagnostic and prognostic biomarkers in both PIDs and SIDs.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-1 (Programmed cell death 1) • MIR155 (MicroRNA 155) • MIR21 (MicroRNA 21) • CD200 (CD200 Molecule) • MIR16 (MicroRNA 16) • MIR150 (MicroRNA 150) • MIR181A1 (MicroRNA 181a-1) • MIR29A (MicroRNA 29a) • MIR30C • MIR326 (MicroRNA 326)
    4ms
    Retraction: RAB31 targeted by MiR-30c-2-3p regulates the GLI1 signaling pathway, affecting gastric cancer cell proliferation and apoptosis. (PubMed, Front Oncol)
    [This retracts the article DOI: 10.3389/fonc.2018.00554.].
    Journal
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    MIR30C
    5ms
    Diagnostic and prognostic potential of microRNA profiles in endometrioid endometrial cancer. (PubMed, Sci Rep)
    We showed that miRNAs have good diagnostic sensitivity for identifying EEC and EC grading. In addition, miRNA improved the ability to discriminate between ECs of different grades.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • PTEN (Phosphatase and tensin homolog) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR200B (MicroRNA 200b) • MIR21 (MicroRNA 21) • MIR200C (MicroRNA 200c) • MIR429 (MicroRNA 429) • MIR30B (MicroRNA 30b) • MIR324 (MicroRNA 324) • MIR543 (MicroRNA 543) • MIR96 (MicroRNA 96) • Let-7c (MicroRNA Let-7c) • MIR126 (MicroRNA 126) • MIR141 (MicroRNA 141) • MIR182 (MicroRNA 182) • MIR18A (MicroRNA 18a) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2) • MIR130A (MicroRNA 130a) • MIR181B1 (MicroRNA 181b-1) • MIR183 (MicroRNA 183) • MIR203A (MicroRNA 203a) • MIR205 (MicroRNA 205) • MIR217 (MicroRNA 217) • MIR30C • MIRLET7E (MicroRNA Let-7e)
    6ms
    Near-Infrared-Responsive Digital PCR-Assisted Renal Cancer Exosomal miRNAs Insights and Regulation of Macrophage Polarization. (PubMed, Adv Sci (Weinh))
    This pioneering dPCR method provides a robust tool for early RCC detection through exosomal miRNA profiling and opens new avenues for therapeutic exosome engineering. The study underscores the potential of dPCR-based exosome genotyping in identifying cancer biomarkers and developing novel treatment strategies.
    Journal
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    MIR34A (MicroRNA 34a-5p) • MIR126 (MicroRNA 126) • MIR210 (MicroRNA 210) • MIR30C
    6ms
    A miR-30 Guided Molecular Profiling of Canine Osteosarcoma and Extraskeletal Osteosarcoma Reveals Non-Seed Regulatory Divergence. (PubMed, Cells)
    MiR-30a and miR-30e exhibited the highest diagnostic power (LR+ 7.7 and 6.8, respectively), supporting their role as biomarkers. These results highlight a miR-30-centered regulatory axis with relevance for diagnosis and molecular stratification of canine osteogenic tumors.
    Journal
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    MIR30B (MicroRNA 30b) • KPNA2 (Karyopherin Subunit Alpha 2) • MIR30A (MicroRNA 30a) • MIR30C • MIR30E (MicroRNA 30e) • RUNX2 (RUNX Family Transcription Factor 2)
    6ms
    Mechanistic Study of MiR-30c-5p Regulation of SIRT Expression in Polycystic Ovary Syndrome. (PubMed, Reprod Sci)
    Furthermore, our data confirmed that SIRT1 serves as a direct target of miR-30c-5p. Collectively, these results indicate that miR-30c-5p promotes apoptosis of GCs by directly targeting SIRT1, thereby representing a novel molecular target for improving GC dysfunction in PCOS patients.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • SIRT1 (Sirtuin 1) • MIR30C
    7ms
    Relationship between specific microRNA expression and radioresistant conditions in HL60 acute myeloid leukemia cells. (PubMed, Mol Med Rep)
    Furthermore, Reactome analysis revealed enrichment in the following processes 'Cell cycle, Mitotic' (R‑HAS‑69278), 'Apoptosis' (R‑HAS‑109581) and 'Immune system' (R‑HAS‑168256), suggesting that these miRNAs regulate genes involved in these pathways. These findings indicated that the altered expression of five specific microRNAs in radioresistant AML cells may be associated with radioresistant conditions through the modulation of mRNA expression.
    Journal
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    MIR30C • MIR671 (MicroRNA 671)
    7ms
    A Novel Liver-Specific Pseudogene Biomarker, BMS1P8, for Diagnosis and Prognosis in Hepatocellular Carcinoma. (PubMed, Front Biosci (Landmark Ed))
    Our findings highlight BMS1P8 as a novel liver-specific biomarker with substantial diagnostic and prognostic value in HCC. Its diagnostic utility suggests its potential application in early detection and personalized treatment strategies, contributing to improved patient outcomes.
    Journal
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    MIR30C
    7ms
    Transmucosal Delivery of miR-30c-5p by Chitosan Nanoparticles for Oral Squamous Cell Carcinoma. (PubMed, Int J Nanomedicine)
    CS-NPs enhance miRNA delivery and gene-silencing efficacy in OSCC cells. These findings support CS-based systems for miRNA therapeutics in oral cancer.
    Journal
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    VIM (Vimentin) • MIR30C