MGMT (6-O-methylguanine-DNA methyltransferase)

P1/2, N=35, Recruiting, Assistance Publique - Hôpitaux de Paris | Trial completion date: May 2027 --> Mar 2028 | Trial primary completion date: May 2027 --> Mar 2028

P1, N=30, Not yet recruiting, National Cancer Institute (NCI)

UMBIF showed robust transferability to both post-therapy imaging assessment and molecular status prediction in glioma. By leveraging large-scale self-supervised pretraining to boost performance while reducing dependence on manual annotations, the framework may facilitate more efficient and reliable diagnostic workflows.

P3, N=265, Active, not recruiting, NRG Oncology | Suspended --> Active, not recruiting

Oral mucosa subjected to continuous exposure to CMI is associated with increased methylation of p16 and MGMT. Proper management of mechanical injury factors could be an important measure for OSCC prevention. In CMI, exfoliative cytology and the split-mouth design could be useful tools to study biomarkers. However, the role of CMI in oral carcinogenesis needs more evidence focusing on the biological phenomenon.

The DIR is a novel and robust quantitative MRI biomarker capable of distinguishing between proliferative and infiltrative GBM phenotypes, independently predicting OS. Early phenotype identification could facilitate personalized treatment strategies and individualized follow-up scheduling.

The TTFields combined with Stupp regimen was associated with longer Survival outcome in patients with GBM. Additionally, higher patient compliance with TTFields treatment (≥ 0.81) and prolonged use of TTFields (> 2 months) are closely associated with improved prognosis.

No significance could be detected comparing SI histogram parameters between oligodendrogliomas and diffuse astrocytomas. Our investigation demonstrates the potential of T2 SI Entropy in distinguishing grade 1 from grade 2 gliomas and in reflecting the proliferative activity denoted by Ki-67 expression, therefore being a promising HA feature for assessing tumor heterogeneity.

All patients underwent maximal safe resection followed by adjuvant radiotherapy and concurrent plus maintenance temozolomide (TMZ)...However, in IDHwt patients, unmethylated status was associated with worse OS (HR 3.66, p < 0.001) compared to methylated (HR 2.16, p = 0.009). These findings reaffirm the prognostic significance of IDH mutations and MGMTp methylation in GBM, underscoring their relevance in clinical stratification and treatment planning.

Additionally, a history of hypertension was associated with MGMT promoter methylation after multivariate adjustment (adjusted OR, 3.6; p = 0.03). MGMT promoter methylation in glioblastoma was associated with current smoking and a history of hypertension, suggesting lifestyle-related factors may influence epigenetic mechanisms underlying MGMT promoter methylation in glioblastoma.

Radiomics demonstrates strong potential for the non-invasive prediction of key glioma molecular biomarkers, achieving high diagnostic performance across diverse computational approaches. However, widespread clinical translation remains hindered by heterogeneous imaging protocols, limited standardization, insufficient external validation, and variable methodological rigor.