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DRUG:

methylprednisolone oral

Associations
Company:
Generic mfg.
Drug class:
GCR agonist
Associations
5d
New P2 trial
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prednisone • methylprednisolone oral
21d
EASE-NMO: Eculizumab for Acute Attack of Neuromyelitis Optica Spectrum Disorder (clinicaltrials.gov)
P2, N=75, Not yet recruiting, Tianjin Medical University General Hospital
New P2 trial
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methylprednisolone oral
1m
Methylprednisolone Taper, Lower Extremity (clinicaltrials.gov)
P4, N=200, Recruiting, Emory University | Trial completion date: Sep 2024 --> Dec 2024 | Trial primary completion date: Sep 2024 --> Dec 2024
Trial completion date • Trial primary completion date
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dexamethasone injection • methylprednisolone oral
2ms
Ruxolitinib and Steroid As First Line Therapy for Acute GVHD (clinicaltrials.gov)
P2, N=1, Terminated, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | N=30 --> 1 | Trial completion date: Oct 2021 --> Sep 2024 | Unknown status --> Terminated | Trial primary completion date: Oct 2021 --> Sep 2024; Participants recruitment failure
Enrollment change • Trial completion date • Trial termination • Trial primary completion date
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Jakafi (ruxolitinib) • methylprednisolone oral • methylprednisolone sodium succinate
2ms
Mechanism of Non-puerperal Mastitis in Early Stage and the Value of Glucocorticoids Therapy (ChiCTR2400087655)
P=N/A, N=20, Not yet recruiting, The First Affiliated Hospital of Nanjing Medical University; the First Affiliated Hospital of Nanjing Medical University
New trial
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methylprednisolone oral
3ms
Steroid for Treatment of Acute/Subacute Severe Cerebral Venous Thrombosis. (clinicaltrials.gov)
P=N/A, N=170, Completed, Xuanwu Hospital, Beijing | N=248 --> 170 | Trial completion date: Dec 2021 --> Jul 2024 | Trial primary completion date: Dec 2021 --> Jul 2024
Enrollment change • Trial completion date • Trial primary completion date
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methylprednisolone oral • methylprednisolone sodium succinate
4ms
COTAM: Corticoid Therapy in Acute Myocarditis (clinicaltrials.gov)
P3, N=420, Not yet recruiting, Assistance Publique - Hôpitaux de Paris
New P3 trial
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prednisone • methylprednisolone oral
6ms
DanNORMS: Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis (clinicaltrials.gov)
P3, N=600, Active, not recruiting, Rigshospitalet, Denmark | Recruiting --> Active, not recruiting | Trial completion date: Dec 2028 --> May 2028 | Trial primary completion date: Dec 2025 --> May 2026
Enrollment closed • Trial completion date • Trial primary completion date • Head-to-Head
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FCER1G (Fc Fragment Of IgE Receptor Ig) • NEFL (Neurofilament Light Chain)
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Ruxience (rituximab-pvvr) • Ocrevus (ocrelizumab) • methylprednisolone oral
12ms
Medrol Dosepak for Outpatient Total Knee Arthroplasty (clinicaltrials.gov)
P4, N=420, Recruiting, Rush University Medical Center | Trial completion date: Nov 2024 --> Nov 2025 | Trial primary completion date: Nov 2023 --> Nov 2024
Trial completion date • Trial primary completion date
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methylprednisolone oral
12ms
Methylprednisolone Taper, Lower Extremity (clinicaltrials.gov)
P4, N=200, Recruiting, Emory University | Not yet recruiting --> Recruiting
Enrollment open
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dexamethasone injection • methylprednisolone oral
1year
A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients (clinicaltrials.gov)
P1, N=134, Recruiting, Oncotherapeutics | Trial primary completion date: Sep 2022 --> Sep 2024
Trial primary completion date
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lenalidomide • Jakafi (ruxolitinib) • melphalan • methylprednisolone acetate • methylprednisolone oral
1year
Efficacy of isatuximab in combination with steroids for the treatment of relapsed/refractory multiple myeloma patients exhibiting only biochemical progression-A single center retrospective study. (PubMed, Eur J Haematol)
This study shows that the two-drug class combination of ISAdm is an effective and well tolerated treatment option for RRMM patients exhibiting only BP.
Retrospective data • Journal • Combination therapy
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carfilzomib • dexamethasone • pomalidomide • Sarclisa (isatuximab-irfc) • methylprednisolone oral
over1year
A Rare Vascular Phenomenon: Acroangiodermatitis of Mali (Pseudo-Kaposi Sarcoma) in an Indonesian Patient (WCD 2023)
The patient was treated with 10% urea cream, 0,25% desoximetasone cream, oral cetirizine 10 mg once daily, oral erythromicin 500 mg four times daily, and oral methylprednisolone 8 mg twice daily for a month along with compression stockings and limb elevation during night hours. Furthermore, she received 10 mg/ml triamcinolone acetonide injection every month...This case emphasizes that a suspicious lesion should always undergo biopsy. Appropriate diagnosis and management can help improving patient life quality immensely.
Clinical
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ARVA (Parvin Alpha)
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methylprednisolone oral
over1year
Eosinophilic dermatitis due to triptorelin pamoate in a patient with prostate cancer confirmed by patch testing (EADV-Sp 2023)
Oral antihistamines and a gradually reduce course of oral methylprednisolone starting from 32 mg daily and topical mometasone furoate 0,1% cream improved but did not clear his rash. Clinicians should be aware of triptorelin as a culprit of eosinophilic dermatitis. 18 MAY - 20 MAY 2023 POWERED BY M-ANAGE.COM
Clinical
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triptorelin • methylprednisolone oral
over2years
A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma Patients. (PubMed, Hematol Oncol)
Ruxolitinib with lenalidomide and dexamethasone shows anti-myeloma effects in vitro and in vivo...Subjects received ruxolitinib twice daily, lenalidomide daily on days 1-21 of a 28-day cycle and methylprednisolone orally every other day...This Phase I trial demonstrates that a JAK inhibitor, ruxolitinib, can overcome refractoriness to lenalidomide and steroids for patients with RRMM. These results represent a promising novel therapeutic approach for treating MM.
P1 data • Journal
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MUC1 (Mucin 1)
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lenalidomide • Jakafi (ruxolitinib) • dexamethasone • methylprednisolone oral
almost4years
Extensive cutaneous iatrogenic Kaposi's sarcoma after bullous pemphigoid treatment with oral methylprednisolone: a rare Chinese case report. (PubMed, J Int Med Res)
The Epstein-Barr virus test showed the patient tested negative for immunoglobulin (Ig)A and IgM, but was positive for IgG. Immunosuppression associated with the treatment for BP may activate a latent HHV-8 infection and induce the development of KS.
Clinical • Journal
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CD34 (CD34 molecule) • CD31 (Platelet and endothelial cell adhesion molecule 1)
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methylprednisolone oral
4years
[VIRTUAL] EBV-aggravated colitis as a side effect of immune combination therapy with nivolumab and ipilimumab in metastatic melanoma (ADO 2020)
The integrin antagonist vedolizumab has the advantage over the standard in this situation, the TNFα antibody infliximab, of causing fewer pulmonary infections...In contrast to CMV-aggravated colitis, the usual therapy with ganciclovir in addition to the steroid is not the first choice. Such patients can particularly benefit from anti-inflammatory therapy with vedolizumab, which has a less pulmonary immunosuppressive effect, which in times of coronavirus Pandemic made sense.
Adverse events • Combination therapy
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TNFA (Tumor Necrosis Factor-Alpha)
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Opdivo (nivolumab) • Yervoy (ipilimumab) • Entyvio (vedolizumab) • methylprednisolone oral
4years
[VIRTUAL] Cytokine release syndrome in a patient with metastatic melanoma under BRAF / MEK inhibition (ADO 2020)
The successful use of the IL-6 receptor antagonist tocilizumab has also been described...The patient had been receiving dabrafenib and trametinib for one month after being treated with pembrolizumab as adjuvant...The administration of paracetamol and an imputed antibiotic therapy with piperacillin / tazobactam did not lead to defever, but to further increasing lymphocytopenia and increasing CRP up to 311.5 mg / L (norm: <3 mg / l)...The intravenous administration of 150 mg prednisolone daily for 4 days led to a prompt defever, normalization of weight and resolution of all other symptoms. The patient tolerated the subsequent change in therapy to vemurafenib / cobimetinib without complications. Due to the increasing combination of therapies in patients with metastatic melanoma, the frequency of CRS can increase and should be included in differential diagnostic considerations for the symptoms mentioned above.
Clinical • PD(L)-1 Biomarker
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BRAF (B-raf proto-oncogene) • IL6 (Interleukin 6)
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BRAF V600E • BRAF mutation • BRAF V600 • BRAF V600R
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Keytruda (pembrolizumab) • Mekinist (trametinib) • Zelboraf (vemurafenib) • Tafinlar (dabrafenib) • Cotellic (cobimetinib) • Actemra IV (tocilizumab) • methylprednisolone oral • prednisolone
4years
[VIRTUAL] Two cases of necrotizing neutrophilic dermatoses disguised as necrotizing fasciitis (BAD 2020)
Dapsone was initiated as a steroid sparing agent at 25 mg daily increasing slowly to 75 mg daily as the prednisolone was slowly reduced. The second patient was a 61‐year‐old man with known myelodysplasia...These cases highlight the importance of recognizing acute presentations of NND. They also emphasize the role of dermatologists in ensuring early diagnosis, with consequent avoidance of both unnecessary surgical procedures and the significant morbidity associated with misdiagnosis of NF.
Clinical
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CRP (C-reactive protein)
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methylprednisolone oral • prednisolone
4years
Paraneoplastic Dermatomyositis in a Patient with Metastatic Gastric Carcinoma. (PubMed, Acta Dermatovenerol Croat)
A systemic therapy with methylprednisolone 60 mg/daily and azathioprine 100 mg/daily was initiated, aiming to alleviate the progressively worsening muscle weakness, but proved ineffective. Although it is generally accepted that patients with DM should undergo some type of cancer screening, there is no consensus regarding methods or frequency. New data suggest that blind screening in asymptomatic patients might be of great importance for early diagnosis and treatment of patients with cancer-associated DM.
Clinical • Journal
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CRP (C-reactive protein)
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methylprednisolone oral
over4years
Methylprednisolone potentiates tetrandrine pharmacodynamics against human T lymphoblastoid leukemia MOLT-4 cells via regulation of NF-κB activation and cell cycle transition. (PubMed, Steroids)
These results suggest that nM grade of MP potentiates the cytotoxic effect of TET possibly via regulation of NF-κB activation and "G0/G1 to S" phase transition in human T lymphoblastoid leukemia MOLT-4 cells. Combination of TET and MP may provide a new therapeutic strategy for relapsed T-ALL.
PK/PD data • Journal
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CCNA2 (Cyclin A2)
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CBT-1 (tetrandrine) • methylprednisolone oral
over4years
Rituximab desensitization in pediatric acute lymphoblastic leukemia with severe anaphylaxis. (PubMed, J Oncol Pharm Pract)
HSR to rituximab may be induced by the activation of mast cells and basophils. Desensitization protocols are developed when there is no alternative drug for the underlying condition.
Clinical • Journal
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CD20 (Membrane Spanning 4-Domains A1)
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CD20 positive
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Rituxan (rituximab) • methylprednisolone oral • ondansetron intravenous
over4years
Neuromuscular complications following targeted therapy in cancer patients: beyond the immune checkpoint inhibitors. Case reports and review of the literature. (PubMed, Neurol Sci)
The first patient was treated with the combination of Vemurafenib and Cobimetinib, BRAF and MEK inhibitors, respectively, for a cutaneous melanoma...She was successfully treated with methylprednisolone. The second patient received therapy with Imatinib, tyrosine kinase inhibitor and precursor of the targeted therapy, for a gastrointestinal stromal tumour...DISCUSSION AND  We strengthen the relevance of neuromuscular complications which may occur long after treatment start or in patients receiving not only the latest ICPi but also "older" and apparently better-known targeted therapies. Also in the latter cases, an immune-mediated "off-target" pathogenic mechanism can be hypothesized, and consequences can be life threatening, if not promptly diagnosed and appropriately managed.
Clinical • Journal • Checkpoint inhibition
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BRAF (B-raf proto-oncogene)
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Zelboraf (vemurafenib) • imatinib • Cotellic (cobimetinib) • methylprednisolone oral
over4years
[VIRTUAL] Case of Refractory Sepsis with Bloody Pericarditis or a Masquerade? (ATS-I 2020)
Only 3% patients required pericardiocentesis due to tamponade at the time of the initial presentation. The patient's undiagnosed myelodysplastic syndrome may have led to immunosuppression precipitating acute mumps infection that was potentially a costly red herring although it may have augmented the pathological process.
Clinical
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TP53 (Tumor protein P53)
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TP53 mutation
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methylprednisolone oral
over4years
[VIRTUAL] Tyrosine Kinase Inhibitor Induced Interstitial Lung Disease (ATS-I 2020)
Patient was admitted to the hospital and started on broad-spectrum antibiotics and Osimertinib was held...Osimeritnib induced interstitial lung disease was diagnosed and patient was discharged home on taper dose of prednisone over next several weeks...The diagnosis can be challenging both clinically as well as radiographically as signs and symptoms mimic with other etiologies such as infections. Treatment includes high dose steroids, drug discontinuation, supplemental oxygen and mechanical ventilation in more severe involvement.
PD(L)-1 Biomarker • IO biomarker
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EGFR (Epidermal growth factor receptor) • PD-L1 (Programmed death ligand 1) • ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
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EGFR mutation • EGFR exon 19 deletion • EGFR positive
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Tagrisso (osimertinib) • prednisone • methylprednisolone oral
over4years
[VIRTUAL] Severe Presentation in a Child with Systemic Lupus Erythematosus, and Somatic Mutation of NRAS Gene Without Documented Rasopathy (ATS-I 2020)
Her entire hospital stay included 13 blood transfusions, 4 rounds of monthly cyclophosphamide, high dose methylprednisolone for several weeks, 4 rounds of weekly rituximab, 43 days on HFOV, 57 days on conventional ventilator, and gastrostomy and tracheostomy dependence...Also described is the association of other RAS-associated autoimmune leukoproliferative disorders (KRAS or NRAS mutation) with JMML. To our knowledge there are no documented cases of a patient less than five with severe lupus, presenting with pulmonary alveolar hemorrhage, also known to have a somatic mutation of NRAS gene, which is thought to be less likely to be associated with RASopathy.
Clinical
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KRAS (KRAS proto-oncogene GTPase) • NRAS (Neuroblastoma RAS viral oncogene homolog)
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KRAS mutation • NRAS mutation • NRAS G13
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Rituxan (rituximab) • cyclophosphamide intravenous • methylprednisolone oral
over4years
[VIRTUAL] HAPLOIDENTICAL STEM CELL TRANSPLANTATION (HAPLO-SCT) WITH POST-TRANSPLANT-HD-CYCLOPHOSPHAMIDE FOR RELAPSED B-LYMPHOBLASTIC LYMPHOMA (B-LBL) WITH MLL-REARRANGEMENT IN 1 Y.O. CHILD: A CLINICAL CASE (EBMT 2020)
Cyclosporine A (CyA; 3mg/kg/d i.v., then 6 mg/kg/d p.o. adjusting for blood levels 200-400 ng/ml) and mycophenolate mofetil (MMF; 15mg/kg two times daily per os) were started on day+5...D+56 aGVHD gr.3: skin, gastrointestinal tract, BM (full resolution on therapy with methylprednisolone 2mg/kg, after the withdrawal of methylprednisolone there was a reversal, in therapy - MMF, Basiliximab; full resolution D+100)...D+343 chronic GVHD: skin, BM, febrile, gastrointestinal, treated with methylprednisolone and Rituximab#4... HLA-haploidentical HSCT with post-transplant high-dose cyclophosphamide is feasible and effective in children with relapse B-lymphoblastic Lymphoma. Reason for a-GVHD and cGVHD in this case was connected with high numbers of transfusions in first line of therapy (not always with leukodepleted products).
Clinical
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CD19 (CD19 Molecule) • CD38 (CD38 Molecule) • CD34 (CD34 molecule) • NCAM1 (Neural cell adhesion molecule 1)
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MLL rearrangement
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Rituxan (rituximab) • etoposide IV • cyclosporine • Simulect (basiliximab) • cyclophosphamide intravenous • methylprednisolone oral
over4years
[VIRTUAL] HAPLOIDENTICAL STEM CELL TRANSPLANTATION (HAPLO-SCT) WITH POST-TRANSPLANT-HD-CYCLOPHOSPHAMIDE FOR RELAPSED B-LYMPHOBLASTIC LYMPHOMA (B-LBL) WITH MLL-REARRANGEMENT IN 1 Y.O. CHILD: A CLINICAL CASE (EBMT 2020)
Cyclosporine A (CyA; 3mg/kg/d i.v., then 6 mg/kg/d p.o. adjusting for blood levels 200-400 ng/ml) and mycophenolate mofetil (MMF; 15mg/kg two times daily per os) were started on day+5...D+56 aGVHD gr.3: skin, gastrointestinal tract, BM (full resolution on therapy with methylprednisolone 2mg/kg, after the withdrawal of methylprednisolone there was a reversal, in therapy - MMF, Basiliximab; full resolution D+100)...D+343 chronic GVHD: skin, BM, febrile, gastrointestinal, treated with methylprednisolone and Rituximab#4... HLA-haploidentical HSCT with post-transplant high-dose cyclophosphamide is feasible and effective in children with relapse B-lymphoblastic Lymphoma. Reason for a-GVHD and cGVHD in this case was connected with high numbers of transfusions in first line of therapy (not always with leukodepleted products).
Clinical
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CD19 (CD19 Molecule) • CD38 (CD38 Molecule) • CD34 (CD34 molecule) • NCAM1 (Neural cell adhesion molecule 1)
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MLL rearrangement
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Rituxan (rituximab) • etoposide IV • cyclosporine • Simulect (basiliximab) • cyclophosphamide intravenous • methylprednisolone oral
over4years
[VIRTUAL] HAPLOIDENTICAL STEM CELL TRANSPLANTATION (HAPLO-SCT) WITH POST-TRANSPLANT-HD-CYCLOPHOSPHAMIDE FOR RELAPSED B-LYMPHOBLASTIC LYMPHOMA (B-LBL) WITH MLL-REARRANGEMENT IN 1 Y.O. CHILD: A CLINICAL CASE (EBMT 2020)
Cyclosporine A (CyA; 3mg/kg/d i.v., then 6 mg/kg/d p.o. adjusting for blood levels 200-400 ng/ml) and mycophenolate mofetil (MMF; 15mg/kg two times daily per os) were started on day+5...D+56 aGVHD gr.3: skin, gastrointestinal tract, BM (full resolution on therapy with methylprednisolone 2mg/kg, after the withdrawal of methylprednisolone there was a reversal, in therapy - MMF, Basiliximab; full resolution D+100)...D+343 chronic GVHD: skin, BM, febrile, gastrointestinal, treated with methylprednisolone and Rituximab#4... HLA-haploidentical HSCT with post-transplant high-dose cyclophosphamide is feasible and effective in children with relapse B-lymphoblastic Lymphoma. Reason for a-GVHD and cGVHD in this case was connected with high numbers of transfusions in first line of therapy (not always with leukodepleted products).
Clinical
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CD19 (CD19 Molecule) • CD38 (CD38 Molecule) • CD34 (CD34 molecule) • NCAM1 (Neural cell adhesion molecule 1)
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MLL rearrangement
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Rituxan (rituximab) • etoposide IV • cyclosporine • Simulect (basiliximab) • cyclophosphamide intravenous • methylprednisolone oral
over4years
[VIRTUAL] Subcutaneous panniculitis-like T-cell lymphoma presenting with hemophagocytic syndrome, parotitis, and nodal involvement (AAD-VMX 2020)
The patient was started on cyclophosphamide, doxorubicin, etoposide, vincristine, and prednisone...SPTCL may be associated with SLE and the skin findings are often difficult to distinguish between lupus erythematosus panniculitis. SPTCL patients rarely develop hemophagocytic syndrome, and those that do have a poorer prognosis.
IO biomarker
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KEAP1 (Kelch Like ECH Associated Protein 1) • CD8 (cluster of differentiation 8) • IL2 (Interleukin 2)
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doxorubicin hydrochloride • etoposide IV • vincristine • prednisone • cyclophosphamide intravenous • methylprednisolone oral
over4years
Correlation between serum levels of endothelin-1 and disease severity in patients with neuromyelitis optica spectrum disorders. (PubMed, Immunobiology)
ET-1 and IL-6 might exert pro-inflammatory effects in the pathogenesis of NMOSD, whereas IL-10 played an anti-inflammatory role in this process. ET-1 might be a potential biomarker for predicting the severity of NMOSD. However, the serum levels of ET-1 were not correlated with the changes of other cytokines/chemokines in patients with NMOSD. The involvement of ET-1 in the development of NMOSD needs to be further studied.
Clinical • Journal
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IL6 (Interleukin 6) • IL10 (Interleukin 10)
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methylprednisolone oral
over4years
Toripalimab-Induced Dermatomyositis in a Patient with Metastatic Melanoma. (PubMed, Dermatol Ther (Heidelb))
The symptoms were relieved by discontinuing toripalimab and administering once-daily intravenous methylprednisolone 1 mg/kg. We suggest that this case serves a warning to clinicians of the need to be aware of the possiblilty of toripalimab-induced dermatomyositis. Early recognition and treatment may prevent progression and improve prognosis of this irAE.
Clinical • Journal
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PD-1 (Programmed cell death 1)
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Loqtorzi (toripalimab-tpzi) • methylprednisolone oral
over4years
[VIRTUAL] HIGH EFFICACY AND SAFETY OF RUXOLITINIB IN TREATING STEROIDS RESISTANT CRS DURING CAR T THERAPY, A PILOT STUDY (EHA 2020)
Methods During October 2019 and January 2020, Patients were included in our pilot study when they developed rapidly to severe CRS (≥3) in 4 days after CAR T cell infusion, and Tocilizumab (8mg/kg/dose) and Steroids (2 to 15 mg/kg/d methylprednisolone) could not alleviate the symptoms...No adverse effects related to ruxolitinib were observed. Conclusion Our study demonstrated the high efficacy and safety of ruxolitinib in treating steroids resistant CRS during CAR T therapy, especially for patients who had early relapse after allo-HCT and high leukemia burden
Clinical
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IFNG (Interferon, gamma) • IL6 (Interleukin 6) • JAK1 (Janus Kinase 1) • IL10 (Interleukin 10)
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Jakafi (ruxolitinib) • Actemra IV (tocilizumab) • methylprednisolone oral
over4years
Reduction of FoxP3 Tregs by an immunosuppressive protocol of rapamycin plus Thymalfasin and Huaier extract predicts positive survival benefits in a rat model of hepatocellular carcinoma. (PubMed, Ann Transl Med)
We successfully established a rat model simulating HCC relapse after LT using an optimized chemical induction method with TACROLIMUS, methylprednisolone, and diethylnitrosamine as identified by visible liver nodules and hematoxylin-eosin staining. FoxP3Tregs showed a negative correlation with CD8 and CD4/CD8T cells and a positive correlation with AFP, and VEGF (P<0.05). SRL-based therapy reduces FoxP3Tregs to decrease secreted inhibitory cytokines which may enhancement the viability and number of CD8T cells to exert anti-tumor effects that are mainly mediated through the AKT-mTOR signaling pathway.
Journal
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CD8 (cluster of differentiation 8) • AFP (Alpha-fetoprotein) • IL10 (Interleukin 10) • FOXP3 (Forkhead Box P3)
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sirolimus • Zadaxin (thymalfasin) • methylprednisolone oral
over4years
Overlapping syndrome of MOG-IgG-associated disease and autoimmune GFAP astrocytopathy. (PubMed, J Neurol)
Treatment strategy employing intravenous methylprednisolone pulse therapy followed by oral prednisone with slow tapering resulted in an improvement of his symptoms and a sustained remission. Coexistence of MOG-IgG and GFAP-IgG with distinct underlying pathogeneses necessitates the recommendations to screen all recognized pathogenic antibodies against CNS antigens when an autoimmune disease is suspected, since it shows great significance for definite diagnosis of disease and treatment strategy options.
Journal
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GFAP (Glial Fibrillary Acidic Protein)
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prednisone • methylprednisolone oral
over4years
A novel CX3CR1 inhibitor AZD8797 facilitates early recovery of rat acute spinal cord injury by inhibiting inflammation and apoptosis. (PubMed, Int J Mol Med)
Another batch of rats (subdivided into sham, injury model, AZD8797 and methylprednisolone groups) were used to evaluate locomotive recovery with a Basso Beattie Bresnahan score. The effect of AZD8797 was mediated by suppressing apoptosis, necrosis and inflammatory responses, as assessed by WB/ELISA and morphological examinations. The current study has demonstrated that AZD8797 can effectively block overwhelming inflammation, apoptosis and necrosis after SCI and facilitate early recovery of locomotive function.
Preclinical • Journal
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BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CASP3 (Caspase 3)
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KAND567 • methylprednisolone oral
over4years
Exosomes derived from Wharton's jelly of human umbilical cord mesenchymal stem cells reduce osteocyte apoptosis in glucocorticoid-induced osteonecrosis of the femoral head in rats via the miR-21-PTEN-AKT signalling pathway. (PubMed, Int J Biol Sci)
To evaluate the effects of exosomes in GIONFH, a dexamethasone-treated or exosome-treated in vitro cell model and a methylprednisolone-treated in vivo rat model were set up. Exosomes are effective at inhibiting osteocyte apoptosis (in MLO-Y4 cells) and at preventing rat GIONFH. These beneficial effects are mediated by the miR-21-PTEN-AKT signalling pathway.
Preclinical • Journal
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PTEN (Phosphatase and tensin homolog) • MIR21 (MicroRNA 21)
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PTEN overexpression
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dexamethasone • methylprednisolone oral