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DRUG:

MesoPher (autologous dendritic cell vaccine)

i
Other names: autologous dendritic cell vaccine, allogeneic tumour cell lysate pulsed autologous dendritic cells
Associations
Company:
Amphera, Erasmus MC
Drug class:
Immunostimulant
Related drugs:
Associations
10ms
DENIM: DENdritic Cell Immunotherapy for Mesothelioma (clinicaltrials.gov)
P2/3, N=176, Completed, Amphera BV | Recruiting --> Completed
Trial completion
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MesoPher (autologous dendritic cell vaccine)
1year
MesoPher/Mitazalimab-combination Therapy in Metastatic Pancreatic Disease (REACtiVe-2 Trial) (clinicaltrials.gov)
P1, N=22, Completed, Joachim Aerts, MD PhD | Recruiting --> Completed | Trial completion date: Oct 2023 --> May 2023 | Trial primary completion date: Oct 2023 --> May 2023
Trial completion • Trial completion date • Trial primary completion date • Combination therapy • IO biomarker • Metastases
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CD40 (CD40 Molecule)
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MesoPher (autologous dendritic cell vaccine) • mitazalimab (ADC-1013)
over1year
Dendritic Cell Immunotherapy Versus Best Supportive Care as Maintenance Treatment in Patients with Pleural Mesothelioma (IASLC-WCLC 2023)
The DENIM trial is a randomised phase III study in patients with UPM comparing MesoPher, as a maintenance treatment after completion of first line chemotherapy versus best supportive care (BSC). Eligible patients were non progressing after 4-6 cycles of platinum/pemetrexed. The DENIM study failed to show increased OS with MesoPher. Likely the long interval between chemotherapy and the start of treatment caused that most patients had already disease progression before or during the first 3 DC treatments, prohibiting the induction of an effective immune response. This interval was extended compared to earlier MesoPher studies because randomization and additional sterility tests.
Clinical • PD(L)-1 Biomarker • IO biomarker
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CD4 (CD4 Molecule)
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CD4 expression
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pemetrexed • MesoPher (autologous dendritic cell vaccine)
almost2years
New P1 trial • Combination therapy • IO biomarker • Metastases
|
CD40 (CD40 Molecule)
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MesoPher (autologous dendritic cell vaccine) • mitazalimab (ADC-1013)