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    BIOMARKER:

    MELK overexpression

    i
    Other names: MELK, Maternal Embryonic Leucine Zipper Kinase, Tyrosine-Protein Kinase MELK, Protein Kinase PK38, Protein Kinase Eg3, PEg3 Kinase, HPK38
    Entrez ID:
    9833
    3d
    Up-Regulation of MELK Promotes Cell Growth and Invasion by Accelerating G1/S Transition and Indicates Poor Prognosis in Lung Adenocarcinoma. (PubMed, Mol Biotechnol)
    Our outcomes manifest that MELK can function as a beneficial prognostic indication and a new therapy target for LUAD. MELK has an essential function in progressing LUAD, manifesting potential as a viable target for therapeutic intervention in this disease management.
    Journal
    |
    CCNE1 (Cyclin E1) • MELK (Maternal Embryonic Leucine Zipper Kinase)
    |
    MELK overexpression
    21d
    Targeting MELK improves PD-1 blockade efficiency in cervical cancer via enhancing antitumor immunity. (PubMed, Mol Ther Oncol)
    Finally, MELK overexpression conferred tolerance to PD-1 blockade in cervical tumors, whereas targeting MELK by OTSSP167 significantly enhanced PD-1 blockade efficiency. Our data elucidated a novel role of MELK in regulating Th1/Th2 balance and anti-PD-1 immunotherapy in cervical cancer.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • IL6 (Interleukin 6) • MELK (Maternal Embryonic Leucine Zipper Kinase) • IL4 (Interleukin 4)
    |
    MELK overexpression
    |
    OTS167