P=N/A, N=23, Completed, Brigham and Women's Hospital | Active, not recruiting --> Completed

A 39 year old female with signs of hyperandrogenism, was diagnosed with congenital adrenal hyperplasia after a cortrosyn test...Multiple endocrine neoplasia syndromes describe a group of heterogeneous diseases. Hyperparathyroidism is common among multiple endocrine neoplasia syndromes.

P=N/A, N=76, Completed, University of Virginia | Active, not recruiting --> Completed

The present results identified melanocortin receptors 3 and 4 as novel and viable therapeutic targets for glioblastoma. Activation of these receptors by bremelanotide may inhibit the expression of survivin, thereby sensitizing glioblastoma cells to cell death.

P=N/A, N=76, Active, not recruiting, University of Virginia | Not yet recruiting --> Active, not recruiting | N=135 --> 76 | Trial completion date: Dec 2023 --> Jun 2024 | Trial primary completion date: Dec 2022 --> Jun 2023

P2, N=46, Terminated, Hospices Civils de Lyon | N=88 --> 46 | Trial completion date: Dec 2023 --> Nov 2022 | Recruiting --> Terminated; Interim analysis and decision of the independent committee, investigators and sponsor (futility) (2023/10/05)

P1, N=144, Recruiting, University of Virginia | Trial completion date: May 2024 --> May 2026 | Trial primary completion date: Apr 2024 --> Apr 2026

P=N/A, N=84, Active, not recruiting, University of Virginia | Recruiting --> Active, not recruiting | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Aug 2023 --> Aug 2024

Adrenal rest tumors can give rise to high androgen levels in spite of suppressive supraphysiological glucocorticoid doses. This case illustrates, for the first time, the value of 11C-metomidate PET as a sensitive method in documenting adrenal rest tumors, currently considered rare in women with CAH.

When results are analyzed using all available information, a number of novel predicted associations related to ACC appear to be valid according to current knowledge. We expect the predicted relations will be useful for drug repositioning in ACC since the resulting ranked lists of drugs and protein targets can be used to expedite the necessary clinical processes.

Cosyntropin stimulation test showed a 30-minute cortisol of 2.8 mcg/dL and a 60-minute cortisol of 4 mcg/dL...She was started on levothyroxine 88 mcg, DDAVP 0.1 mg PO twice daily and stress dose steroids which was weaned down to prednisone 7.5 mg daily eventually...This case represents a rare occurrence of ATRT and suggests the need for suspicion in case of rapidly growing pituitary mass with progressive panhypopititarism.