^
Contact us to learn more about
our Premium Content: News alerts, weekly reports and conference plannersBIOMARKER:
MED23 expression
i
Other names: MED23, Mediator Complex Subunit 23 , Cofactor Required For Sp1 Transcriptional Activation Subunit 3, Mental Retardation, Non-Syndromic, Autosomal Recessive, 18, Mediator Of RNA Polymerase II Transcription Subunit 23, Activator-Recruited Cofactor 130 KDa Component, DRIP130, ARC130, CRSP3, SUR2, Cofactor Required For Sp1 Transcriptional Activation, Subunit 3, 130kDa, Vitamin D3 Receptor-Interacting Protein Complex 130 KDa Component , Vitamin D3 Receptor Interacting Protein, 130 KDa Transcriptional
Contact us to learn more about our Premium Content:
News alerts, weekly reports and conference planners
Entrez ID:
over1year
MED23 depletion induces premature senescence in NSCLC cells by interacting with BCLAF1 and then suppressing NUPR1 expression. (PubMed, Biochem Biophys Res Commun)
Subsequently, NUPR1, a transcriptional cofactor known to induce premature senescence in lung cancer cells by disrupting autophagic processes, was validated as a downstream target of the MED23/BCLAF1 complex through RNA-seq and ChIP assays. Thus, the interaction between MED23 and BCLAF1 regulates NUPR1 expression, impacting autophagic flux and leading to premature senescence in NSCLC cells.
Journal
|
BCLAF1 (BCL2 Associated Transcription Factor 1) • MED23 (Mediator Complex Subunit 23) • NUPR1 (Nuclear Protein 1 Transcriptional Regulator, Candidate Of Metastasis 1)
|
MED23 expression • NUPR1 expression
Share via
