MDNA132 is an engineered IL13Rα2 selective superkine that accumulates in TME of IL13Rα2 expressing tumors in mice. MDNA109FEAA-Fc-MDNA132 and anti-PD1-MDNA132 retain their respective receptor binding profile, IL2R agonism and PD1/PDL1 blockade illustrating the versatilityof MDNA132 BiSKIT platform for targeted delivery of a broad range of therapeutic and/or immune-modulatory agents to tumors overexpressing the IL13α2 decoy receptor.
MDNA132-based BiSKITs retain receptor binding profileand biological function of both MDNA132 and the fusion partner. MDNA132localizes preferentially to IL-13Rα2 tumors in mice. These data highlight theversatility of MDNA132 and its potential to localize delivery of immunotherapeutics to the TME of cancers expressing IL-13Rα2.