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    BIOMARKER:

    MDC1 mutation

    i
    Other names: MDC1, Mediator Of DNA Damage Checkpoint 1, NFBD1, Mediator Of DNA Damage Checkpoint Protein 1, Nuclear Factor With BRCT Domains 1, KIAA0170, Homologue To Drosophila Photoreceptor Protein Calphotin, Mediator Of DNA-Damage Checkpoint 1, Em:AB023051.5
    Entrez ID:
    9656
    almost2years
    Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach. (PubMed, Syst Biol Reprod Med)
    The present study concludes that the highly deleterious P194R mutations can potentially induce genomic instability and contribute to various cancers' pathogenesis. Developing drugs targeting these mutations can undoubtedly be advantageous in large population-based studies, particularly in the development of precision medicine.
    Journal
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    MDC1 (Mediator Of DNA Damage Checkpoint 1)
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    MDC1 mutation
    over2years
    Impact of programmed death-ligand 1 (PD-L1) positivity on clinical and molecular features of patients with metastatic gastric cancer. (PubMed, Cancer Med)
    PD-L1 expression is an independent and sensitive biomarker for ICI therapy. Considering its significant association with several gene alterations, including PIK3CA mutations and MET amplification, combining ICI therapy with other targeted agents may be a promising therapeutic strategy for GC.
    Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker • Metastases
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    PD-L1 (Programmed death ligand 1) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden) • MET (MET proto-oncogene, receptor tyrosine kinase) • MSI (Microsatellite instability) • TET2 (Tet Methylcytosine Dioxygenase 2) • LRP1B (LDL Receptor Related Protein 1B) • IRS2 (Insulin receptor substrate 2) • PTPRT (Protein tyrosine phosphatase receptor type T) • DOT1L (DOT1 Like Histone Lysine Methyltransferase) • MDC1 (Mediator Of DNA Damage Checkpoint 1)
    |
    PD-L1 expression • TMB-H • PIK3CA mutation • MET amplification • TET2 mutation • MET mutation • MDC1 mutation