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GENE:

MCM5 (Minichromosome Maintenance Complex Component 5)

News alerts, weekly reports and conference planners

Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)

The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.

1 month ago

Journal

TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)

2ms

Dysregulation of atrazine-associated core gene networks and risk prediction in human cancers: Insights from integrated transcriptomics and network toxicology analyses. (PubMed, Ecotoxicol Environ Saf)

This study demonstrates that atrazine promotes carcinogenesis by dysregulating conserved networks governing genomic stability, cell proliferation, metabolic adaptation, and immune microenvironment remodeling, providing a mechanistic framework linking aquatic atrazine exposure to multi-organ carcinogenesis and nominating HSD17B8-associated pathways for therapeutic intervention. These findings underscore the imperative for enhanced environmental monitoring of atrazine contamination.

2 months ago

Journal

CDCA8 (Cell Division Cycle Associated 8) • FEN1 (Flap Structure-Specific Endonuclease 1) • MCM5 (Minichromosome Maintenance Complex Component 5) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)

2ms

SPP1, LYZ, and MCM5: potential diagnostic biomarkers for rheumatoid arthritis and cervical cancer comorbidity. (PubMed, Front Med (Lausanne))

This study successfully identified SPP1, LYZ, and MCM5 as key hub genes for the comorbidity of RA and cervical cancer. By regulating processes like inflammation, immune evasion, and cell proliferation, these genes not only have a high diagnostic potential but may also contribute to the occurrence and development of cervical cancer.

2 months ago

Journal

SPP1 (Secreted Phosphoprotein 1) • MCM5 (Minichromosome Maintenance Complex Component 5)

3ms

A novel dual CDC25-HDAC inhibitor suppresses glioblastoma progression via chromosomal passenger complex disruption. (PubMed, Biomed Pharmacother)

Glioblastoma (GBM) is a highly aggressive and therapeutically challenging brain tumor characterized by poor prognosis, rapid recurrence, and resistance to standard treatments such as temozolomide (TMZ)...Disruption of CPC function led to reduced mitotic activity and increased mitotic defects in treated cultures. Collectively, these findings indicate that dual inhibition of CDC25 and HDAC by MPT1B394 disrupts CPC-mediated mitosis and aberrant cell cycle progression, representing a promising therapeutic avenue for GBM treatment.

3 months ago

Journal

BIRC5 (Baculoviral IAP repeat containing 5) • PLK1 (Polo Like Kinase 1) • CCNA2 (Cyclin A2) • RASGRF1 (Ras Protein Specific Guanine Nucleotide Releasing Factor 1) • CCNB1 (Cyclin B1) • CDCA8 (Cell Division Cycle Associated 8) • CENPA (Centromere protein A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • MCM5 (Minichromosome Maintenance Complex Component 5)

temozolomide

3ms

Comprehensive Bioinformatics and Functional Analysis Identified MCM5 Facilitates Glioblastoma Progression Through Cell Cycle Regulation. (PubMed, Biochem Genet)

In vitro and in vivo experiments showed that MCM5 enhances GBM cell proliferation, migratory capacity, and cell cycle progression. By bioinformatics analysis and cell experiments, MCM5 is found to promote the progression of GBM by accelerating cell cycle. These findings will provide new clues for the mechanism exploration and prognostic prediction of GBM.

3 months ago

Journal

MCM5 (Minichromosome Maintenance Complex Component 5)

3ms

circZNF462 inhibits cadmium-induced DNA damage in bronchial epithelial cells by regulating chromatin accessibility. (PubMed, Toxicol Sci)

Reduction of MCM5 reversed the induction of DNA damage after Cd exposure by low levels of circZNF462. These findings underscore the role of circZNF462-regulated chromatin accessibility in Cd-induced DNA damage, and suggest that the epigenetic molecule circZNF462 might serve as a potential biomarker and early intervention target for preventing environmentally related genetic damage events.

3 months ago

Journal

MCM5 (Minichromosome Maintenance Complex Component 5)

4ms

‌Liquid-Liquid Phase Separation of AR Orchestrated by Melatonin Sensitizes Prostate Cancer to Ferroptosis Via MCM5/NRF2 Axis Collapse. (PubMed, J Pineal Res)

Crucially, downregulated MCM5 attenuated its physical interaction with NRF2, leading to uncontrolled activation of the NRF2/HMOX1 pathway, GPX4 suppression, and accumulation of ferroptosis hallmarks. These findings defined an AR/MCM5/NRF2 axis regulating ferroptosis susceptibility, establishing MEL as the first-reported ferroptosis inducer that expands the mechanistic foundation and therapeutic potential of MEL-based PCa treatment strategies.

4 months ago

Journal

HMOX1 (Heme Oxygenase 1) • GPX4 (Glutathione Peroxidase 4) • MCM5 (Minichromosome Maintenance Complex Component 5)

5ms

TRIM21 promotes colorectal cancer development through regulating DNA replication by TCF3/MCM2/5 axis. (PubMed, Cell Death Discov)

TCF3 directly suppressed MCM2 and MCM5 transcription, inhibiting DNA replication. In summary, TRIM21 could influence tumor development and chemosensitivity to replication inhibitors by regulating DNA replication through the TCF3/MCM2/5 axis, suggesting a promising potential for CRC in the clinic.

5 months ago

Journal

TCF3 (Transcription Factor 3) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • TRIM21 (Tripartite Motif Containing 21)

5-fluorouracil

5ms

Proteomic profiling identifies miR-423-5p as a modulator of oncogenic metabolism in HCC. (PubMed, J Transl Med)

miR-423-5p acts as a tumor suppressor in HCC by targeting key nodes of pro-tumorigenic signalling. miR-423-5p significantly altered metabolic pathways, including purine/pyrimidine metabolism and gluconeogenesis. Seven miR-423-5p targets correlate with poor prognosis in TCGA-LIHC patients and are downregulated in miR-423-5p overexpressing HCC cells. miR-423-5p over-expression induces a significant downregulation of MCM7, DVL3, IMPDH1, SPEE in HCC cell models. miR-423-5p limits tumor metabolic plasticity, suggesting therapeutic potential.

5 months ago

Journal

RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) • ACACA (Acetyl-CoA Carboxylase Alpha) • MCM5 (Minichromosome Maintenance Complex Component 5) • MCM7 (Minichromosome Maintenance Complex Component 7) • MIR423 (MicroRNA 423)

sorafenib

6ms

The lncRNA ELDR suppresses tumorigenicity of AML by interfering with DNA replication and chromatin accessibility. (PubMed, Blood Adv)

These discoveries could provide rationale for future strategies to treat MLL-r AML, which has a poor prognosis in children and adults. Delivery of the ELDR RNA could potentially be utilized as an adjunct to LSD1i/ATRA treatment or other currently used chemotherapeutic drugs to develop novel therapies for these AML subtypes.

6 months ago

Journal

KMT2A (Lysine Methyltransferase 2A) • PCNA (Proliferating cell nuclear antigen) • MCM5 (Minichromosome Maintenance Complex Component 5)

MLL rearrangement

6ms

tRNA modifications are required for stress granule formation and melanoma metastasis. (PubMed, bioRxiv)

Efficient translation, mediated by the carboxy-methylation arm of the mcm 5 s 2 U 34 modification, is required for metastasizing cancer cells to withstand stress via stress granule formation and increase survival throughout the metastatic cascade. This makes the mcm 5 s 2 U 34 machinery a potentially actionable therapeutic target, specific to metastatic disease.

6 months ago

Journal

MCM5 (Minichromosome Maintenance Complex Component 5)

6ms

Construction and Validation of a Novel Prognostic Model Based on Cervical Cancer-Related Genes. (PubMed, Reprod Sci)

APOD is a prognostic biomarker for cervical cancer, and the prognostic model constructed by identified cervical cancer-related genes can successfully distinguish the prognosis of patients with cervical cancer.

6 months ago

Journal

TOP2A (DNA topoisomerase 2-alpha) • RAD54L (DNA Repair And Recombination Protein RAD54) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • MYBL2 (MYB Proto-Oncogene Like 2) • CDC45 (Cell Division Cycle 45) • CEP55 (Centrosomal Protein 55) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • RFC4 (Replication Factor C Subunit 4) • DNA2 (DNA Replication Helicase/Nuclease 2) • SPAG5 (Sperm Associated Antigen 5)